Impact of changes in Clostridium difficile diagnostic testing on detection of C. difficile infection and all England mandatory surveillance data
Summary Following the report of the Centre for Evidence-based Purchasing, which suggested poor performance of Clostridium difficile testing kits, revised guidance was issued by the Department of Health (England) recommending a two-test algorithm. The aim of this study was to survey English National...
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| Veröffentlicht in: | The Journal of hospital infection 2011-09, Vol.79 (1), p.8-12 |
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| container_title | The Journal of hospital infection |
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| creator | Chand, M.A Fleming, M.J Wellsteed, S Kelsey, M.C |
| description | Summary Following the report of the Centre for Evidence-based Purchasing, which suggested poor performance of Clostridium difficile testing kits, revised guidance was issued by the Department of Health (England) recommending a two-test algorithm. The aim of this study was to survey English National Health Service (NHS) diagnostic microbiology laboratories using an electronic questionnaire to investigate changes in laboratory procedures in response to the guidance and model the impact these changes had on national and locally reported data. It was found that 24% of laboratories had changed testing procedures and there was no evidence of an overall effect on the English mandatory surveillance data used for performance management. It was shown that there could be an impact on an individual NHS Trust’s case numbers, and a simple model for Trusts to predict these changes in C. difficile laboratory diagnosis was developed. There was also evidence of the use of variable sample selection criteria, which could affect the positive and negative predictive values of local testing. |
| doi_str_mv | 10.1016/j.jhin.2011.05.012 |
| format | Article |
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The aim of this study was to survey English National Health Service (NHS) diagnostic microbiology laboratories using an electronic questionnaire to investigate changes in laboratory procedures in response to the guidance and model the impact these changes had on national and locally reported data. It was found that 24% of laboratories had changed testing procedures and there was no evidence of an overall effect on the English mandatory surveillance data used for performance management. It was shown that there could be an impact on an individual NHS Trust’s case numbers, and a simple model for Trusts to predict these changes in C. difficile laboratory diagnosis was developed. There was also evidence of the use of variable sample selection criteria, which could affect the positive and negative predictive values of local testing.</description><identifier>ISSN: 0195-6701</identifier><identifier>EISSN: 1532-2939</identifier><identifier>DOI: 10.1016/j.jhin.2011.05.012</identifier><identifier>PMID: 21764171</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Bacterial diseases ; Bacterial diseases of the digestive system and abdomen ; Biological and medical sciences ; Clinical Laboratory Techniques - methods ; Clostridium difficile ; Clostridium difficile - isolation & purification ; Diagnosis ; England - epidemiology ; Enterocolitis, Pseudomembranous - diagnosis ; Enterocolitis, Pseudomembranous - epidemiology ; Enterocolitis, Pseudomembranous - microbiology ; Gastroenterology. Liver. Pancreas. Abdomen ; Human bacterial diseases ; Humans ; Incidence ; Infectious Disease ; Infectious diseases ; Mandatory Reporting ; Medical sciences ; Other diseases. Semiology ; Reagent kits ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Surveys and Questionnaires</subject><ispartof>The Journal of hospital infection, 2011-09, Vol.79 (1), p.8-12</ispartof><rights>The Healthcare Infection Society</rights><rights>2011 The Healthcare Infection Society</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 The Healthcare Infection Society. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-c813540e2ac2433c9df75426705393dd8c5d8e6f406e5990047b7499d950cff33</citedby><cites>FETCH-LOGICAL-c472t-c813540e2ac2433c9df75426705393dd8c5d8e6f406e5990047b7499d950cff33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jhin.2011.05.012$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24483049$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21764171$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chand, M.A</creatorcontrib><creatorcontrib>Fleming, M.J</creatorcontrib><creatorcontrib>Wellsteed, S</creatorcontrib><creatorcontrib>Kelsey, M.C</creatorcontrib><title>Impact of changes in Clostridium difficile diagnostic testing on detection of C. difficile infection and all England mandatory surveillance data</title><title>The Journal of hospital infection</title><addtitle>J Hosp Infect</addtitle><description>Summary Following the report of the Centre for Evidence-based Purchasing, which suggested poor performance of Clostridium difficile testing kits, revised guidance was issued by the Department of Health (England) recommending a two-test algorithm. The aim of this study was to survey English National Health Service (NHS) diagnostic microbiology laboratories using an electronic questionnaire to investigate changes in laboratory procedures in response to the guidance and model the impact these changes had on national and locally reported data. It was found that 24% of laboratories had changed testing procedures and there was no evidence of an overall effect on the English mandatory surveillance data used for performance management. It was shown that there could be an impact on an individual NHS Trust’s case numbers, and a simple model for Trusts to predict these changes in C. difficile laboratory diagnosis was developed. There was also evidence of the use of variable sample selection criteria, which could affect the positive and negative predictive values of local testing.</description><subject>Bacterial diseases</subject><subject>Bacterial diseases of the digestive system and abdomen</subject><subject>Biological and medical sciences</subject><subject>Clinical Laboratory Techniques - methods</subject><subject>Clostridium difficile</subject><subject>Clostridium difficile - isolation & purification</subject><subject>Diagnosis</subject><subject>England - epidemiology</subject><subject>Enterocolitis, Pseudomembranous - diagnosis</subject><subject>Enterocolitis, Pseudomembranous - epidemiology</subject><subject>Enterocolitis, Pseudomembranous - microbiology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infectious Disease</subject><subject>Infectious diseases</subject><subject>Mandatory Reporting</subject><subject>Medical sciences</subject><subject>Other diseases. Semiology</subject><subject>Reagent kits</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Surveys and Questionnaires</subject><issn>0195-6701</issn><issn>1532-2939</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUs2KFDEQbkRxx9UX8CC5iKdpK3_dHRBhGVZdWPCgnkM2P7MZu9Nj0r0wj-Eb-Cw-mdXM6IIHvaSKqu-rvy9V9ZxCTYE2r3f17jammgGlNcgaKHtQrajkbM0UVw-rFVAl100L9Kx6UsoOADAuH1dnjLaNoC1dVd-vhr2xExkDsbcmbX0hMZFNP5YpRxfngbgYQrSx9-iZbcJEtGTyaNKWjIk4P3k7RfSwxqb--eOeEFM4pUxyxPQ9uUzbfvEHfMw05gMpc77zsceoxQ5mMk-rR8H0xT872fPqy7vLz5sP6-uP7682F9drK1o2rW1HuRTgmbFMcG6VC60UDLeVXHHnOitd55sgoPFSKQDR3rRCKack2BA4P69eHevu8_htxn30EIv1yyR-nItWIIRiIJr_IruOdxJASkSyI9LmsZTsg97nOJh80BT0opne6UUzvWimQWrUDEkvTuXnm8G7P5TfIiHg5QlgijV9yHirWO5xQnQchELcmyPO49nuos-62Ojxri5m1EG7Mf57jrd_0W0fU8SOX_3Bl90454SCaKoL06A_Lb9r-VyUAjBJFf8FiarLaA</recordid><startdate>20110901</startdate><enddate>20110901</enddate><creator>Chand, M.A</creator><creator>Fleming, M.J</creator><creator>Wellsteed, S</creator><creator>Kelsey, M.C</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QL</scope><scope>C1K</scope></search><sort><creationdate>20110901</creationdate><title>Impact of changes in Clostridium difficile diagnostic testing on detection of C. difficile infection and all England mandatory surveillance data</title><author>Chand, M.A ; Fleming, M.J ; Wellsteed, S ; Kelsey, M.C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c472t-c813540e2ac2433c9df75426705393dd8c5d8e6f406e5990047b7499d950cff33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Bacterial diseases</topic><topic>Bacterial diseases of the digestive system and abdomen</topic><topic>Biological and medical sciences</topic><topic>Clinical Laboratory Techniques - methods</topic><topic>Clostridium difficile</topic><topic>Clostridium difficile - isolation & purification</topic><topic>Diagnosis</topic><topic>England - epidemiology</topic><topic>Enterocolitis, Pseudomembranous - diagnosis</topic><topic>Enterocolitis, Pseudomembranous - epidemiology</topic><topic>Enterocolitis, Pseudomembranous - microbiology</topic><topic>Gastroenterology. 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| subjects | Bacterial diseases Bacterial diseases of the digestive system and abdomen Biological and medical sciences Clinical Laboratory Techniques - methods Clostridium difficile Clostridium difficile - isolation & purification Diagnosis England - epidemiology Enterocolitis, Pseudomembranous - diagnosis Enterocolitis, Pseudomembranous - epidemiology Enterocolitis, Pseudomembranous - microbiology Gastroenterology. Liver. Pancreas. Abdomen Human bacterial diseases Humans Incidence Infectious Disease Infectious diseases Mandatory Reporting Medical sciences Other diseases. Semiology Reagent kits Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Surveys and Questionnaires |
| title | Impact of changes in Clostridium difficile diagnostic testing on detection of C. difficile infection and all England mandatory surveillance data |
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