Distribution and clonal relationship of cell surface virulence genes among Streptococcus pneumoniae isolates in Japan
Streptococcus pneumoniae resides on mucosal surfaces in the nasopharynx, where selection for horizontal transfer of antimicrobial resistance genes and virulence factors may provide a survival advantage. We investigated the distribution of genes for pneumococcal cell surface proteins and their correl...
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| Veröffentlicht in: | Clinical microbiology and infection 2011-09, Vol.17 (9), p.1409-1414 |
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| creator | Imai, S. Ito, Y. Ishida, T. Hirai, T. Ito, I. Yoshimura, K. Maekawa, K. Takakura, S. Niimi, A. Iinuma, Y. Ichiyama, S. Mishima, M. |
| description | Streptococcus pneumoniae resides on mucosal surfaces in the nasopharynx, where selection for horizontal transfer of antimicrobial resistance genes and virulence factors may provide a survival advantage. We investigated the distribution of genes for pneumococcal cell surface proteins and their correlations with multilocus sequence typing (MLST), Pneumococcal Molecular Epidemiology Network (PMEN) clones and antimicrobial resistance, to identify pneumococcal virulence factors predicting prevalent clones from 156 pneumococcal isolates recovered from adult patients with community-acquired pneumonia in Japan. Pneumococcal eno, pavA, piuA, cbpA and cbpG were present in all isolates, and hyl and piaA were distributed among the clinical isolates. In contrast, pneumococcal rlrA, pclA, psrP, nanC and pspA family 1-type genes were variably distributed and significantly associated with MLST (Wallace coefficients (W) were over 84%). Serotype was a weaker predictor of sequence type (W, 0.75) than vice versa (W, 0.97). A multiple logistic regression analysis adjusted to the presence of virulence genes, pspA family 1 genes and carriage serotypes revealed that pclA and rlrA correlated with PMEN clones and antimicrobial resistance, and are likely to contribute to the selection of prevalent clones. |
| doi_str_mv | 10.1111/j.1469-0691.2010.03446.x |
| format | Article |
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We investigated the distribution of genes for pneumococcal cell surface proteins and their correlations with multilocus sequence typing (MLST), Pneumococcal Molecular Epidemiology Network (PMEN) clones and antimicrobial resistance, to identify pneumococcal virulence factors predicting prevalent clones from 156 pneumococcal isolates recovered from adult patients with community-acquired pneumonia in Japan. Pneumococcal eno, pavA, piuA, cbpA and cbpG were present in all isolates, and hyl and piaA were distributed among the clinical isolates. In contrast, pneumococcal rlrA, pclA, psrP, nanC and pspA family 1-type genes were variably distributed and significantly associated with MLST (Wallace coefficients (W) were over 84%). Serotype was a weaker predictor of sequence type (W, 0.75) than vice versa (W, 0.97). A multiple logistic regression analysis adjusted to the presence of virulence genes, pspA family 1 genes and carriage serotypes revealed that pclA and rlrA correlated with PMEN clones and antimicrobial resistance, and are likely to contribute to the selection of prevalent clones.</description><identifier>ISSN: 1198-743X</identifier><identifier>EISSN: 1469-0691</identifier><identifier>DOI: 10.1111/j.1469-0691.2010.03446.x</identifier><identifier>PMID: 21143699</identifier><language>eng</language><publisher>Oxford, UK: Elsevier Ltd</publisher><subject>Adult ; Analysis of Variance ; Antimicrobial agents ; Bacterial diseases ; Bacterial Proteins - genetics ; Biological and medical sciences ; Carriage serotypes ; Cell surface ; Clinical isolates ; Cohort Studies ; Community-Acquired Infections - epidemiology ; Community-Acquired Infections - microbiology ; Drug resistance ; Epidemiology ; Genes ; Horizontal transfer ; Human bacterial diseases ; Humans ; Infectious diseases ; Japan - epidemiology ; Medical sciences ; Molecular Epidemiology ; Mucosa ; Multilocus Sequence Typing ; multilocus sequencing typing ; Nasopharynx ; pclA ; Pneumonia ; Pneumonia, Pneumococcal - epidemiology ; Pneumonia, Pneumococcal - microbiology ; PspA protein ; Regression analysis ; rlrA ; Serotypes ; Serotyping ; Staphylococcal infections, streptococcal infections, pneumococcal infections ; Streptococcus infections ; Streptococcus pneumoniae ; Streptococcus pneumoniae - genetics ; Streptococcus pneumoniae - isolation & purification ; Streptococcus pneumoniae - pathogenicity ; virulence factors ; Virulence Factors - genetics</subject><ispartof>Clinical microbiology and infection, 2011-09, Vol.17 (9), p.1409-1414</ispartof><rights>2011 European Society of Clinical Infectious Diseases</rights><rights>2011 The Authors. Clinical Microbiology and Infection © 2011 European Society of Clinical Microbiology and Infectious Diseases</rights><rights>2015 INIST-CNRS</rights><rights>2011 The Authors. 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We investigated the distribution of genes for pneumococcal cell surface proteins and their correlations with multilocus sequence typing (MLST), Pneumococcal Molecular Epidemiology Network (PMEN) clones and antimicrobial resistance, to identify pneumococcal virulence factors predicting prevalent clones from 156 pneumococcal isolates recovered from adult patients with community-acquired pneumonia in Japan. Pneumococcal eno, pavA, piuA, cbpA and cbpG were present in all isolates, and hyl and piaA were distributed among the clinical isolates. In contrast, pneumococcal rlrA, pclA, psrP, nanC and pspA family 1-type genes were variably distributed and significantly associated with MLST (Wallace coefficients (W) were over 84%). Serotype was a weaker predictor of sequence type (W, 0.75) than vice versa (W, 0.97). A multiple logistic regression analysis adjusted to the presence of virulence genes, pspA family 1 genes and carriage serotypes revealed that pclA and rlrA correlated with PMEN clones and antimicrobial resistance, and are likely to contribute to the selection of prevalent clones.</description><subject>Adult</subject><subject>Analysis of Variance</subject><subject>Antimicrobial agents</subject><subject>Bacterial diseases</subject><subject>Bacterial Proteins - genetics</subject><subject>Biological and medical sciences</subject><subject>Carriage serotypes</subject><subject>Cell surface</subject><subject>Clinical isolates</subject><subject>Cohort Studies</subject><subject>Community-Acquired Infections - epidemiology</subject><subject>Community-Acquired Infections - microbiology</subject><subject>Drug resistance</subject><subject>Epidemiology</subject><subject>Genes</subject><subject>Horizontal transfer</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Japan - epidemiology</subject><subject>Medical sciences</subject><subject>Molecular Epidemiology</subject><subject>Mucosa</subject><subject>Multilocus Sequence Typing</subject><subject>multilocus sequencing typing</subject><subject>Nasopharynx</subject><subject>pclA</subject><subject>Pneumonia</subject><subject>Pneumonia, Pneumococcal - epidemiology</subject><subject>Pneumonia, Pneumococcal - microbiology</subject><subject>PspA protein</subject><subject>Regression analysis</subject><subject>rlrA</subject><subject>Serotypes</subject><subject>Serotyping</subject><subject>Staphylococcal infections, streptococcal infections, pneumococcal infections</subject><subject>Streptococcus infections</subject><subject>Streptococcus pneumoniae</subject><subject>Streptococcus pneumoniae - genetics</subject><subject>Streptococcus pneumoniae - isolation & purification</subject><subject>Streptococcus pneumoniae - pathogenicity</subject><subject>virulence factors</subject><subject>Virulence Factors - genetics</subject><issn>1198-743X</issn><issn>1469-0691</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkVtvFCEUgInR2Hb1LxgSY3yaFQaGy4MPutZb1vigJr4RhoHKZhamMNT238u4a018qSSEk8N3DpcPAIjRGtfxYrfGlMkGMYnXLapZRChl6-t74PR2436NsRQNp-T7CTjLeYcQagmhD8FJizElTMpTUN74PCffl9nHAHUYoBlj0CNMdtRLLv_wE4wOGjuOMJfktLHwyqcy2lCjCxtshnofwwX8Mic7zdFEY0qGU7Clpr220OdYm1XOB_hRTzo8Ag-cHrN9fFxX4Nvb86-b983287sPm1fbxnSMs6ZzZMB95yTpnJAUS8yk0LwVrZYE9T1lhDjs7KA7bHqEe4lNy8UgezI46jRZgeeHvlOKl8XmWe19Xl6ig40lK4kolZhzcScpJBeYkDpX4Ok_5C6WVL8sK9zRThLBZVspcaBMijkn69SU_F6nG4WRWhyqnVpUqUWVWhyq3w7VdS19cjyg9Hs73Bb-kVaBZ0dAZ6NHl3QwPv_lahvGBa_cywP304_25r8voDbbT0tU618f6m1VdOVtUtn4xfrgkzWzGqK_-zW_AIQgzaU</recordid><startdate>201109</startdate><enddate>201109</enddate><creator>Imai, S.</creator><creator>Ito, Y.</creator><creator>Ishida, T.</creator><creator>Hirai, T.</creator><creator>Ito, I.</creator><creator>Yoshimura, K.</creator><creator>Maekawa, K.</creator><creator>Takakura, S.</creator><creator>Niimi, A.</creator><creator>Iinuma, Y.</creator><creator>Ichiyama, S.</creator><creator>Mishima, M.</creator><general>Elsevier Ltd</general><general>Blackwell Publishing Ltd</general><general>Wiley-Blackwell</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>201109</creationdate><title>Distribution and clonal relationship of cell surface virulence genes among Streptococcus pneumoniae isolates in Japan</title><author>Imai, S. ; 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We investigated the distribution of genes for pneumococcal cell surface proteins and their correlations with multilocus sequence typing (MLST), Pneumococcal Molecular Epidemiology Network (PMEN) clones and antimicrobial resistance, to identify pneumococcal virulence factors predicting prevalent clones from 156 pneumococcal isolates recovered from adult patients with community-acquired pneumonia in Japan. Pneumococcal eno, pavA, piuA, cbpA and cbpG were present in all isolates, and hyl and piaA were distributed among the clinical isolates. In contrast, pneumococcal rlrA, pclA, psrP, nanC and pspA family 1-type genes were variably distributed and significantly associated with MLST (Wallace coefficients (W) were over 84%). Serotype was a weaker predictor of sequence type (W, 0.75) than vice versa (W, 0.97). A multiple logistic regression analysis adjusted to the presence of virulence genes, pspA family 1 genes and carriage serotypes revealed that pclA and rlrA correlated with PMEN clones and antimicrobial resistance, and are likely to contribute to the selection of prevalent clones.</abstract><cop>Oxford, UK</cop><pub>Elsevier Ltd</pub><pmid>21143699</pmid><doi>10.1111/j.1469-0691.2010.03446.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Access via Wiley Online Library; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Adult Analysis of Variance Antimicrobial agents Bacterial diseases Bacterial Proteins - genetics Biological and medical sciences Carriage serotypes Cell surface Clinical isolates Cohort Studies Community-Acquired Infections - epidemiology Community-Acquired Infections - microbiology Drug resistance Epidemiology Genes Horizontal transfer Human bacterial diseases Humans Infectious diseases Japan - epidemiology Medical sciences Molecular Epidemiology Mucosa Multilocus Sequence Typing multilocus sequencing typing Nasopharynx pclA Pneumonia Pneumonia, Pneumococcal - epidemiology Pneumonia, Pneumococcal - microbiology PspA protein Regression analysis rlrA Serotypes Serotyping Staphylococcal infections, streptococcal infections, pneumococcal infections Streptococcus infections Streptococcus pneumoniae Streptococcus pneumoniae - genetics Streptococcus pneumoniae - isolation & purification Streptococcus pneumoniae - pathogenicity virulence factors Virulence Factors - genetics |
| title | Distribution and clonal relationship of cell surface virulence genes among Streptococcus pneumoniae isolates in Japan |
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