In vitro antitrypanosomal activity of plant terpenes against Trypanosoma brucei

The antitrypanosomal activity of 24 known plant terpenes was evaluated against Trypanosoma brucei brucei. Among them, α-eudesmol, hinesol, nardosinone and 4-peroxy-1,2,4,5-tetrahydro-α-santonin exhibited selective and potent antitrypanosomal activities. [Display omitted] ► The antitrypanosomal activ...

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Veröffentlicht in:	Phytochemistry (Oxford) 2011-11, Vol.72 (16), p.2024-2030
Hauptverfasser:	Otoguro, Kazuhiko, Iwatsuki, Masato, Ishiyama, Aki, Namatame, Miyuki, Nishihara-Tukashima, Aki, Kiyohara, Hiroaki, Hashimoto, Toshihiro, Asakawa, Yoshinori, Ōmura, Satoshi, Yamada, Haruki
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics. Antiinfectious agents. Antiparasitic agents Antiparasitic agents Antitrypanosomal Biological and medical sciences Chemical constitution Diterpenes - chemistry Diterpenes - isolation & purification Diterpenes - pharmacology Eflornithine - pharmacology Fundamental and applied biological sciences. Psychology In vitro Medical sciences Pharmacology. Drug treatments Plant physiology and development Plant products Plants - chemistry Structure-Activity Relationship Suramin - pharmacology Terpenes Terpenes - chemistry Terpenes - isolation & purification Terpenes - pharmacology Trypanocidal Agents - chemistry Trypanocidal Agents - isolation & purification Trypanocidal Agents - pharmacology Trypanosoma brucei Trypanosoma brucei brucei Trypanosoma brucei brucei - drug effects
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