Let-7 microRNA–mediated regulation of IL-13 and allergic airway inflammation

Background IL-13, a cytokine secreted by TH 2 lymphocytes and other cells, critically modulates allergic inflammation and tissue remodeling in allergic asthma. Although much is known about transcriptional regulation of IL-13, posttranscriptional regulation is poorly understood. Objective Because man...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2011-11, Vol.128 (5), p.1077-1085.e10
Hauptverfasser:	Kumar, Manish, MSc, Ahmad, Tanveer, MSc, Sharma, Amit, PhD, Mabalirajan, Ulaganathan, MBBS, PhD, Kulshreshtha, Ankur, MTech, Agrawal, Anurag, MD, PhD, Ghosh, Balaram, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	airway hyperresponsiveness allergic airway inflammation Allergy and Immunology Animals Asthma - genetics Asthma - immunology Asthma - metabolism Biological and medical sciences Blotting, Northern Cell Line Cell Separation Flow Cytometry Fundamental and applied biological sciences. Psychology Fundamental immunology Gene Expression Gene Expression Regulation - genetics Humans IL-13 Immunopathology Interleukin-13 - biosynthesis Interleukin-13 - genetics Interleukin-13 - immunology Let-7 microRNA Lungs Lymphocytes Male Medical sciences Mice Mice, Inbred BALB C MicroRNAs MicroRNAs - genetics MicroRNAs - immunology MicroRNAs - metabolism Muscular system Pneumonia - genetics Pneumonia - immunology Pneumonia - metabolism posttranscriptional regulation primary T cells Real-Time Polymerase Chain Reaction Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Transfection
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