Reciprocal regulation of CXCR4 and CXCR7 in intestinal mucosal homeostasis and inflammatory bowel disease

Differential regulation of CXCL12 receptors is suggested as mechanism to modulate T cells function in mucosal homeostasis and inflammation. IBDs are characterized by increased influx of immune cells to the mucosa of genetically susceptible persons. Cellular migration to injury sites is mediated by c...

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Veröffentlicht in:	Journal of leukocyte biology 2011-09, Vol.90 (3), p.583-590
Hauptverfasser:	Werner, Lael, Elad, Hofit, Brazowski, Eli, Tulchinsky, Hagit, Vigodman, Sharon, Kopylov, Uri, Halpern, Zamir, Guzner‐Gur, Hanan, Dotan, Iris
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Movement Cell Proliferation Cells, Cultured Chemokine CXCL12 - metabolism chemokines Crohnˈs disease CXCL12 Cytokines - metabolism Flow Cytometry Homeostasis Humans Inflammatory Bowel Diseases - metabolism Inflammatory Bowel Diseases - pathology Intestinal Mucosa - cytology Intestinal Mucosa - metabolism Receptors, CXCR - metabolism Receptors, CXCR4 - metabolism Signal Transduction T-Lymphocytes - immunology T-Lymphocytes - metabolism ulcerative colitis
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