Lutzomyia longipalpis saliva drives apoptosis and enhances parasite burden in neutrophils

Salivary proteins from Lutzomyia longipalpis induce host neutrophil caspase‐dependent apoptosis and infection by Leishmania chagasi. Neutrophils are considered the hostˈs first line of defense against infections and have been implicated in the immunopathogenesis of Leishmaniasis. Leishmania parasite...

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Veröffentlicht in:	Journal of leukocyte biology 2011-09, Vol.90 (3), p.575-582
Hauptverfasser:	Prates, Deboraci Brito, Araújo‐Santos, Théo, Luz, Nívea Farias, Andrade, Bruno B., França‐Costa, Jaqueline, Afonso, Lilian, Clarêncio, Jorge, Miranda, José Carlos, Bozza, Patrícia T., DosReis, George A., Brodskyn, Cláudia, Barral‐Netto, Manoel, Borges, Valéria Matos, Barral, Aldina
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Caspases - metabolism cell death Chemokine CCL2 - metabolism Chemotaxis Fas Ligand Protein - metabolism FasL Female Host-Parasite Interactions Immunoblotting Leishmania Leishmania chagasi Leishmaniasis - immunology Leishmaniasis - parasitology Lutzomyia longipalpis Macrophages - immunology Male Mice Mice, Inbred C57BL Neutrophils - immunology Neutrophils - parasitology Neutrophils - pathology Psychodidae - immunology Psychodidae - parasitology Reactive Oxygen Species - metabolism Saliva - chemistry Saliva - immunology Saliva - parasitology Salivary Glands - cytology Salivary Glands - immunology Salivary Glands - parasitology sand fly
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