Mycoplasmal lipid-associated membrane proteins and Mycoplasma arthritidis mitogen recognition by serum antibodies from patients with rheumatoid arthritis
Mycoplasmal lipid-associated membrane proteins (LAMPs) and Mycoplasma arthritidis mitogen (MAM superantigen) are potent stimulators of the immune system. The objective of this work was to detect antibodies to MAM and LAMPs of Mycoplasma hominis and M. fermentans in the sera of patients affected by r...
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| Veröffentlicht in: | Rheumatology international 2011-07, Vol.31 (7), p.951-957 |
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| creator | da Rocha Sobrinho, Hermínio M. Jarach, Renata da Silva, Nilzio A. Shio, Marina T. Jancar, Sonia Timenetsky, Jorge Oliveira, Milton A. P. Dorta, Miriam L. Ribeiro-Dias, Fátima |
| description | Mycoplasmal lipid-associated membrane proteins (LAMPs) and
Mycoplasma arthritidis
mitogen (MAM superantigen) are potent stimulators of the immune system. The objective of this work was to detect antibodies to MAM and LAMPs of
Mycoplasma hominis
and
M. fermentans
in the sera of patients affected by rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) to identify mycoplasmal products that can be involved in the etiopathogenesis of these autoimmune diseases. Serum samples from female RA and SLE patients and controls, recombinant MAM, and LAMPs of
M. hominis
PG21 and
M. fermentans
PG18 were used in Western blot assays. A similar frequency of sera from patients and controls reactive to MAM was detected. A larger number of
M. hominis
and
M. fermentans
LAMPs were recognized by sera from RA patients than controls, but no differences were detected between sera from SLE patients and controls. Among the LAMPs recognized by IgG antibodies from RA patients, proteins of molecular masses in a range of |
| doi_str_mv | 10.1007/s00296-010-1612-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_904489937</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>873494523</sourcerecordid><originalsourceid>FETCH-LOGICAL-c402t-c128f0d299050e6df038d94b578b378933b42a3834dbb2e2465b0e8e04b6386b3</originalsourceid><addsrcrecordid>eNqFkc2KFDEUhYMoTjv6AG4kuHFVevNTVclSBv9gxI2CuyKp3OrOUKmUSQrpR_FtTdPjDAjiJuEm3znJ4RDynMFrBtC_yQBcdw0waFjHeMMekB2Toq8TfH9IdsB63qi6XJAnOd9AnbsOHpMLzqDlXS935Nfn4xjX2eRgZjr71bvG5BxHbwo6GjDYZBaka4oF_ZKpWRy9l1CTyiH54p3PNPgS97jQhGPcL_UwLtQeaca0haor3kbnMdMpxUBXUzwuJdOfvhxoOuAWTIne3Tnmp-TRZOaMz273S_Lt_buvVx-b6y8fPl29vW5GCbw0I-NqAse1hhawcxMI5bS0ba-s6JUWwkpuhBLSWcuRy661gApB2k6ozopL8ursWzP-2DCXIfg84jzX3HHLgwYpldai_y-peiG1bLmo5Mu_yJu4paXGOEGsflyf7NgZGlPMOeE0rMkHk44Dg-HU73Dud4DTXPsdWNW8uDXebEB3p_hTaAX4Gcj1atljun_5366_ARBqs2Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>873140297</pqid></control><display><type>article</type><title>Mycoplasmal lipid-associated membrane proteins and Mycoplasma arthritidis mitogen recognition by serum antibodies from patients with rheumatoid arthritis</title><source>MEDLINE</source><source>SpringerLink Journals (MCLS)</source><creator>da Rocha Sobrinho, Hermínio M. ; Jarach, Renata ; da Silva, Nilzio A. ; Shio, Marina T. ; Jancar, Sonia ; Timenetsky, Jorge ; Oliveira, Milton A. P. ; Dorta, Miriam L. ; Ribeiro-Dias, Fátima</creator><creatorcontrib>da Rocha Sobrinho, Hermínio M. ; Jarach, Renata ; da Silva, Nilzio A. ; Shio, Marina T. ; Jancar, Sonia ; Timenetsky, Jorge ; Oliveira, Milton A. P. ; Dorta, Miriam L. ; Ribeiro-Dias, Fátima</creatorcontrib><description>Mycoplasmal lipid-associated membrane proteins (LAMPs) and
Mycoplasma arthritidis
mitogen (MAM superantigen) are potent stimulators of the immune system. The objective of this work was to detect antibodies to MAM and LAMPs of
Mycoplasma hominis
and
M. fermentans
in the sera of patients affected by rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) to identify mycoplasmal products that can be involved in the etiopathogenesis of these autoimmune diseases. Serum samples from female RA and SLE patients and controls, recombinant MAM, and LAMPs of
M. hominis
PG21 and
M. fermentans
PG18 were used in Western blot assays. A similar frequency of sera from patients and controls reactive to MAM was detected. A larger number of
M. hominis
and
M. fermentans
LAMPs were recognized by sera from RA patients than controls, but no differences were detected between sera from SLE patients and controls. Among the LAMPs recognized by IgG antibodies from RA patients, proteins of molecular masses in a range of <49 and ≥20 KDa (
M. hominis
) and <102 and ≥58 KDa (
M. fermentans
) were the most reactive. These preliminary results demonstrate the strong reactivity of antibodies of RA patients with some
M. hominis
and
M. fermentans
LAMPs. These LAMPs could be investigated as mycoplasmal antigens that can take part in the induction or amplification of human autoimmune responses.</description><identifier>ISSN: 0172-8172</identifier><identifier>EISSN: 1437-160X</identifier><identifier>DOI: 10.1007/s00296-010-1612-1</identifier><identifier>PMID: 21052674</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adult ; Aged ; Antigens, Bacterial - immunology ; Arthritis, Rheumatoid - immunology ; Arthritis, Rheumatoid - microbiology ; Autoantibodies - blood ; Cross Reactions - immunology ; Female ; Humans ; Immunoglobulin G - blood ; Lupus Erythematosus, Systemic - immunology ; Lupus Erythematosus, Systemic - microbiology ; Lysosomal Membrane Proteins - immunology ; Medicine ; Medicine & Public Health ; Middle Aged ; Mycoplasma arthritidis ; Mycoplasma hominis ; Mycoplasma Infections - immunology ; Rheumatology ; Short Communication ; Superantigens - immunology</subject><ispartof>Rheumatology international, 2011-07, Vol.31 (7), p.951-957</ispartof><rights>Springer-Verlag 2010</rights><rights>Springer-Verlag 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c402t-c128f0d299050e6df038d94b578b378933b42a3834dbb2e2465b0e8e04b6386b3</citedby><cites>FETCH-LOGICAL-c402t-c128f0d299050e6df038d94b578b378933b42a3834dbb2e2465b0e8e04b6386b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00296-010-1612-1$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00296-010-1612-1$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21052674$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>da Rocha Sobrinho, Hermínio M.</creatorcontrib><creatorcontrib>Jarach, Renata</creatorcontrib><creatorcontrib>da Silva, Nilzio A.</creatorcontrib><creatorcontrib>Shio, Marina T.</creatorcontrib><creatorcontrib>Jancar, Sonia</creatorcontrib><creatorcontrib>Timenetsky, Jorge</creatorcontrib><creatorcontrib>Oliveira, Milton A. P.</creatorcontrib><creatorcontrib>Dorta, Miriam L.</creatorcontrib><creatorcontrib>Ribeiro-Dias, Fátima</creatorcontrib><title>Mycoplasmal lipid-associated membrane proteins and Mycoplasma arthritidis mitogen recognition by serum antibodies from patients with rheumatoid arthritis</title><title>Rheumatology international</title><addtitle>Rheumatol Int</addtitle><addtitle>Rheumatol Int</addtitle><description>Mycoplasmal lipid-associated membrane proteins (LAMPs) and
Mycoplasma arthritidis
mitogen (MAM superantigen) are potent stimulators of the immune system. The objective of this work was to detect antibodies to MAM and LAMPs of
Mycoplasma hominis
and
M. fermentans
in the sera of patients affected by rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) to identify mycoplasmal products that can be involved in the etiopathogenesis of these autoimmune diseases. Serum samples from female RA and SLE patients and controls, recombinant MAM, and LAMPs of
M. hominis
PG21 and
M. fermentans
PG18 were used in Western blot assays. A similar frequency of sera from patients and controls reactive to MAM was detected. A larger number of
M. hominis
and
M. fermentans
LAMPs were recognized by sera from RA patients than controls, but no differences were detected between sera from SLE patients and controls. Among the LAMPs recognized by IgG antibodies from RA patients, proteins of molecular masses in a range of <49 and ≥20 KDa (
M. hominis
) and <102 and ≥58 KDa (
M. fermentans
) were the most reactive. These preliminary results demonstrate the strong reactivity of antibodies of RA patients with some
M. hominis
and
M. fermentans
LAMPs. These LAMPs could be investigated as mycoplasmal antigens that can take part in the induction or amplification of human autoimmune responses.</description><subject>Adult</subject><subject>Aged</subject><subject>Antigens, Bacterial - immunology</subject><subject>Arthritis, Rheumatoid - immunology</subject><subject>Arthritis, Rheumatoid - microbiology</subject><subject>Autoantibodies - blood</subject><subject>Cross Reactions - immunology</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoglobulin G - blood</subject><subject>Lupus Erythematosus, Systemic - immunology</subject><subject>Lupus Erythematosus, Systemic - microbiology</subject><subject>Lysosomal Membrane Proteins - immunology</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Mycoplasma arthritidis</subject><subject>Mycoplasma hominis</subject><subject>Mycoplasma Infections - immunology</subject><subject>Rheumatology</subject><subject>Short Communication</subject><subject>Superantigens - immunology</subject><issn>0172-8172</issn><issn>1437-160X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkc2KFDEUhYMoTjv6AG4kuHFVevNTVclSBv9gxI2CuyKp3OrOUKmUSQrpR_FtTdPjDAjiJuEm3znJ4RDynMFrBtC_yQBcdw0waFjHeMMekB2Toq8TfH9IdsB63qi6XJAnOd9AnbsOHpMLzqDlXS935Nfn4xjX2eRgZjr71bvG5BxHbwo6GjDYZBaka4oF_ZKpWRy9l1CTyiH54p3PNPgS97jQhGPcL_UwLtQeaca0haor3kbnMdMpxUBXUzwuJdOfvhxoOuAWTIne3Tnmp-TRZOaMz273S_Lt_buvVx-b6y8fPl29vW5GCbw0I-NqAse1hhawcxMI5bS0ba-s6JUWwkpuhBLSWcuRy661gApB2k6ozopL8ursWzP-2DCXIfg84jzX3HHLgwYpldai_y-peiG1bLmo5Mu_yJu4paXGOEGsflyf7NgZGlPMOeE0rMkHk44Dg-HU73Dud4DTXPsdWNW8uDXebEB3p_hTaAX4Gcj1atljun_5366_ARBqs2Q</recordid><startdate>20110701</startdate><enddate>20110701</enddate><creator>da Rocha Sobrinho, Hermínio M.</creator><creator>Jarach, Renata</creator><creator>da Silva, Nilzio A.</creator><creator>Shio, Marina T.</creator><creator>Jancar, Sonia</creator><creator>Timenetsky, Jorge</creator><creator>Oliveira, Milton A. P.</creator><creator>Dorta, Miriam L.</creator><creator>Ribeiro-Dias, Fátima</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7QL</scope><scope>C1K</scope></search><sort><creationdate>20110701</creationdate><title>Mycoplasmal lipid-associated membrane proteins and Mycoplasma arthritidis mitogen recognition by serum antibodies from patients with rheumatoid arthritis</title><author>da Rocha Sobrinho, Hermínio M. ; Jarach, Renata ; da Silva, Nilzio A. ; Shio, Marina T. ; Jancar, Sonia ; Timenetsky, Jorge ; Oliveira, Milton A. P. ; Dorta, Miriam L. ; Ribeiro-Dias, Fátima</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c402t-c128f0d299050e6df038d94b578b378933b42a3834dbb2e2465b0e8e04b6386b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antigens, Bacterial - immunology</topic><topic>Arthritis, Rheumatoid - immunology</topic><topic>Arthritis, Rheumatoid - microbiology</topic><topic>Autoantibodies - blood</topic><topic>Cross Reactions - immunology</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoglobulin G - blood</topic><topic>Lupus Erythematosus, Systemic - immunology</topic><topic>Lupus Erythematosus, Systemic - microbiology</topic><topic>Lysosomal Membrane Proteins - immunology</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Mycoplasma arthritidis</topic><topic>Mycoplasma hominis</topic><topic>Mycoplasma Infections - immunology</topic><topic>Rheumatology</topic><topic>Short Communication</topic><topic>Superantigens - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>da Rocha Sobrinho, Hermínio M.</creatorcontrib><creatorcontrib>Jarach, Renata</creatorcontrib><creatorcontrib>da Silva, Nilzio A.</creatorcontrib><creatorcontrib>Shio, Marina T.</creatorcontrib><creatorcontrib>Jancar, Sonia</creatorcontrib><creatorcontrib>Timenetsky, Jorge</creatorcontrib><creatorcontrib>Oliveira, Milton A. P.</creatorcontrib><creatorcontrib>Dorta, Miriam L.</creatorcontrib><creatorcontrib>Ribeiro-Dias, Fátima</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Rheumatology international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>da Rocha Sobrinho, Hermínio M.</au><au>Jarach, Renata</au><au>da Silva, Nilzio A.</au><au>Shio, Marina T.</au><au>Jancar, Sonia</au><au>Timenetsky, Jorge</au><au>Oliveira, Milton A. P.</au><au>Dorta, Miriam L.</au><au>Ribeiro-Dias, Fátima</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mycoplasmal lipid-associated membrane proteins and Mycoplasma arthritidis mitogen recognition by serum antibodies from patients with rheumatoid arthritis</atitle><jtitle>Rheumatology international</jtitle><stitle>Rheumatol Int</stitle><addtitle>Rheumatol Int</addtitle><date>2011-07-01</date><risdate>2011</risdate><volume>31</volume><issue>7</issue><spage>951</spage><epage>957</epage><pages>951-957</pages><issn>0172-8172</issn><eissn>1437-160X</eissn><abstract>Mycoplasmal lipid-associated membrane proteins (LAMPs) and
Mycoplasma arthritidis
mitogen (MAM superantigen) are potent stimulators of the immune system. The objective of this work was to detect antibodies to MAM and LAMPs of
Mycoplasma hominis
and
M. fermentans
in the sera of patients affected by rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) to identify mycoplasmal products that can be involved in the etiopathogenesis of these autoimmune diseases. Serum samples from female RA and SLE patients and controls, recombinant MAM, and LAMPs of
M. hominis
PG21 and
M. fermentans
PG18 were used in Western blot assays. A similar frequency of sera from patients and controls reactive to MAM was detected. A larger number of
M. hominis
and
M. fermentans
LAMPs were recognized by sera from RA patients than controls, but no differences were detected between sera from SLE patients and controls. Among the LAMPs recognized by IgG antibodies from RA patients, proteins of molecular masses in a range of <49 and ≥20 KDa (
M. hominis
) and <102 and ≥58 KDa (
M. fermentans
) were the most reactive. These preliminary results demonstrate the strong reactivity of antibodies of RA patients with some
M. hominis
and
M. fermentans
LAMPs. These LAMPs could be investigated as mycoplasmal antigens that can take part in the induction or amplification of human autoimmune responses.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>21052674</pmid><doi>10.1007/s00296-010-1612-1</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0172-8172 |
| ispartof | Rheumatology international, 2011-07, Vol.31 (7), p.951-957 |
| issn | 0172-8172 1437-160X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_904489937 |
| source | MEDLINE; SpringerLink Journals (MCLS) |
| subjects | Adult Aged Antigens, Bacterial - immunology Arthritis, Rheumatoid - immunology Arthritis, Rheumatoid - microbiology Autoantibodies - blood Cross Reactions - immunology Female Humans Immunoglobulin G - blood Lupus Erythematosus, Systemic - immunology Lupus Erythematosus, Systemic - microbiology Lysosomal Membrane Proteins - immunology Medicine Medicine & Public Health Middle Aged Mycoplasma arthritidis Mycoplasma hominis Mycoplasma Infections - immunology Rheumatology Short Communication Superantigens - immunology |
| title | Mycoplasmal lipid-associated membrane proteins and Mycoplasma arthritidis mitogen recognition by serum antibodies from patients with rheumatoid arthritis |
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