Indole alkaloids from the roots of Isatis ingigotica and their antiherpes simplex virus type 2 (HSV-2) activity in vitro
A new indole alkaloid 1, together with four known indole alkaloids 2-5, was isolated from the 95% EtOH extract of the traditional Chinese medicinal plant Isatis indigotica. Alkaloids 2-5 were found in the plant for the first time. Their structures were elucidated as 3-hydroxy-3-acetonitrile-4-hydrox...
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| Veröffentlicht in: | Chemistry of natural compounds 2010-11, Vol.46 (5), p.763-766 |
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| container_title | Chemistry of natural compounds |
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| creator | Sun, Dong-Dong Dong, Wei-wei Li, Xiang Zhang, Han-Qing |
| description | A new indole alkaloid 1, together with four known indole alkaloids 2-5, was isolated from the 95% EtOH extract of the traditional Chinese medicinal plant Isatis indigotica. Alkaloids 2-5 were found in the plant for the first time. Their structures were elucidated as 3-hydroxy-3-acetonitrile-4-hydroxy-2-indolone (1), 1-methoxy-3-indoleacetonitrile (2), 3-indoleacetic acid (3), 3-indolealdehyde (4), and 1-methoxy-3indolecarbaldehyde (5) on the basis of spectroscopic data. Their anti-HSV effects in vitro were evaluated by plaque reduction assay. |
| doi_str_mv | 10.1007/s10600-010-9735-x |
| format | Article |
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Alkaloids 2-5 were found in the plant for the first time. Their structures were elucidated as 3-hydroxy-3-acetonitrile-4-hydroxy-2-indolone (1), 1-methoxy-3-indoleacetonitrile (2), 3-indoleacetic acid (3), 3-indolealdehyde (4), and 1-methoxy-3indolecarbaldehyde (5) on the basis of spectroscopic data. Their anti-HSV effects in vitro were evaluated by plaque reduction assay.</description><identifier>ISSN: 0009-3130</identifier><identifier>EISSN: 1573-8388</identifier><identifier>DOI: 10.1007/s10600-010-9735-x</identifier><language>eng</language><publisher>Boston: Boston : Springer US</publisher><subject>Alkaloids ; Antiviral agents ; antiviral properties ; Data processing ; Ethanol ; Health aspects ; Indole ; indole acetic acid ; indole alkaloids ; Isatis ; Isatis tinctoria ; Medicinal plants ; Medicine ; Nitriles ; Organic Chemistry ; Oriental traditional medicine ; Pharmacy ; Plant Sciences ; Plaques ; Roots ; Warships</subject><ispartof>Chemistry of natural compounds, 2010-11, Vol.46 (5), p.763-766</ispartof><rights>Springer Science+Business Media, Inc. 2010</rights><rights>COPYRIGHT 2010 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c445t-7d9fbf8a9399045de70a221ca9ddcb3110c840f479c1beab9e278ac9505f47f13</citedby><cites>FETCH-LOGICAL-c445t-7d9fbf8a9399045de70a221ca9ddcb3110c840f479c1beab9e278ac9505f47f13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10600-010-9735-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10600-010-9735-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids></links><search><creatorcontrib>Sun, Dong-Dong</creatorcontrib><creatorcontrib>Dong, Wei-wei</creatorcontrib><creatorcontrib>Li, Xiang</creatorcontrib><creatorcontrib>Zhang, Han-Qing</creatorcontrib><title>Indole alkaloids from the roots of Isatis ingigotica and their antiherpes simplex virus type 2 (HSV-2) activity in vitro</title><title>Chemistry of natural compounds</title><addtitle>Chem Nat Compd</addtitle><description>A new indole alkaloid 1, together with four known indole alkaloids 2-5, was isolated from the 95% EtOH extract of the traditional Chinese medicinal plant Isatis indigotica. Alkaloids 2-5 were found in the plant for the first time. Their structures were elucidated as 3-hydroxy-3-acetonitrile-4-hydroxy-2-indolone (1), 1-methoxy-3-indoleacetonitrile (2), 3-indoleacetic acid (3), 3-indolealdehyde (4), and 1-methoxy-3indolecarbaldehyde (5) on the basis of spectroscopic data. Their anti-HSV effects in vitro were evaluated by plaque reduction assay.</description><subject>Alkaloids</subject><subject>Antiviral agents</subject><subject>antiviral properties</subject><subject>Data processing</subject><subject>Ethanol</subject><subject>Health aspects</subject><subject>Indole</subject><subject>indole acetic acid</subject><subject>indole alkaloids</subject><subject>Isatis</subject><subject>Isatis tinctoria</subject><subject>Medicinal plants</subject><subject>Medicine</subject><subject>Nitriles</subject><subject>Organic Chemistry</subject><subject>Oriental traditional medicine</subject><subject>Pharmacy</subject><subject>Plant Sciences</subject><subject>Plaques</subject><subject>Roots</subject><subject>Warships</subject><issn>0009-3130</issn><issn>1573-8388</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNp9kkGP1CAYhonRxHH1B3iSxIPuoSuUdijHzUbdSTYxcVyvhKEfXda2VD666fx7mdTLJMZwAL48z3vghZC3nF1xxuQn5GzLWME4K5QUdbE8IxteS1E0ommekw1jTBWCC_aSvEJ8zNdmu202ZNmNbeiBmv6X6YNvkboYBpoegMYQEtLg6A5N8kj92PkuJG8NNWN7QnzMp-QfIE6AFP0w9bDQJx9npOk4AS3px9v9z6K8pMYm_-TTMadkIMXwmrxwpkd483e_IPdfPv-4uS3uvn3d3VzfFbaq6lTIVrmDa4wSSrGqbkEyU5bcGtW29iA4Z7apmKuksvwA5qCglI2xqmZ1HjouLsiHNXeK4fcMmPTg0ULfmxHCjDqnVo2q6jqT71eyMz1oP7qQorEnWl-LWvJqK6XM1NU_qLxaGLwNIzif52fC5ZmQmQRL6syMqHf77-csX1kbA2IEp6foBxOPmjN96lmvPevcsz71rJfslKuDmR07iPoxzHHMb_pf6d0qORO06aJHfb8vWf4fXHFRqkr8AZykszo</recordid><startdate>20101101</startdate><enddate>20101101</enddate><creator>Sun, Dong-Dong</creator><creator>Dong, Wei-wei</creator><creator>Li, Xiang</creator><creator>Zhang, Han-Qing</creator><general>Boston : Springer US</general><general>Springer US</general><general>Springer</general><scope>FBQ</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>7U9</scope><scope>H94</scope></search><sort><creationdate>20101101</creationdate><title>Indole alkaloids from the roots of Isatis ingigotica and their antiherpes simplex virus type 2 (HSV-2) activity in vitro</title><author>Sun, Dong-Dong ; Dong, Wei-wei ; Li, Xiang ; Zhang, Han-Qing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-7d9fbf8a9399045de70a221ca9ddcb3110c840f479c1beab9e278ac9505f47f13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Alkaloids</topic><topic>Antiviral agents</topic><topic>antiviral properties</topic><topic>Data processing</topic><topic>Ethanol</topic><topic>Health aspects</topic><topic>Indole</topic><topic>indole acetic acid</topic><topic>indole alkaloids</topic><topic>Isatis</topic><topic>Isatis tinctoria</topic><topic>Medicinal plants</topic><topic>Medicine</topic><topic>Nitriles</topic><topic>Organic Chemistry</topic><topic>Oriental traditional medicine</topic><topic>Pharmacy</topic><topic>Plant Sciences</topic><topic>Plaques</topic><topic>Roots</topic><topic>Warships</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sun, Dong-Dong</creatorcontrib><creatorcontrib>Dong, Wei-wei</creatorcontrib><creatorcontrib>Li, Xiang</creatorcontrib><creatorcontrib>Zhang, Han-Qing</creatorcontrib><collection>AGRIS</collection><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Chemistry of natural compounds</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sun, Dong-Dong</au><au>Dong, Wei-wei</au><au>Li, Xiang</au><au>Zhang, Han-Qing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Indole alkaloids from the roots of Isatis ingigotica and their antiherpes simplex virus type 2 (HSV-2) activity in vitro</atitle><jtitle>Chemistry of natural compounds</jtitle><stitle>Chem Nat Compd</stitle><date>2010-11-01</date><risdate>2010</risdate><volume>46</volume><issue>5</issue><spage>763</spage><epage>766</epage><pages>763-766</pages><issn>0009-3130</issn><eissn>1573-8388</eissn><abstract>A new indole alkaloid 1, together with four known indole alkaloids 2-5, was isolated from the 95% EtOH extract of the traditional Chinese medicinal plant Isatis indigotica. Alkaloids 2-5 were found in the plant for the first time. Their structures were elucidated as 3-hydroxy-3-acetonitrile-4-hydroxy-2-indolone (1), 1-methoxy-3-indoleacetonitrile (2), 3-indoleacetic acid (3), 3-indolealdehyde (4), and 1-methoxy-3indolecarbaldehyde (5) on the basis of spectroscopic data. Their anti-HSV effects in vitro were evaluated by plaque reduction assay.</abstract><cop>Boston</cop><pub>Boston : Springer US</pub><doi>10.1007/s10600-010-9735-x</doi><tpages>4</tpages></addata></record> |
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| ispartof | Chemistry of natural compounds, 2010-11, Vol.46 (5), p.763-766 |
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| language | eng |
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| source | SpringerNature Journals |
| subjects | Alkaloids Antiviral agents antiviral properties Data processing Ethanol Health aspects Indole indole acetic acid indole alkaloids Isatis Isatis tinctoria Medicinal plants Medicine Nitriles Organic Chemistry Oriental traditional medicine Pharmacy Plant Sciences Plaques Roots Warships |
| title | Indole alkaloids from the roots of Isatis ingigotica and their antiherpes simplex virus type 2 (HSV-2) activity in vitro |
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