Risk Factors Influencing Antibody Responses to Kaposiʼs Sarcoma-Associated Herpesvirus Latent and Lytic Antigens in Patients Under Antiretroviral Therapy
BACKGROUND:Kaposiʼs sarcoma-associated herpesvirus (KSHV) seropositivity and lytic antibody titer are predictors for Kaposiʼs sarcoma. METHODS:We examined demographic, viral, and immunologic factors that influence KSHV latent and lytic antibodies in HIV-infected patients. RESULTS:Detection rate of K...
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| Veröffentlicht in: | Journal of acquired immune deficiency syndromes (1999) 2011-01, Vol.56 (1), p.83-90 |
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| creator | Guadalupe, Moraima Pollock, Brad H Westbrook, Steven Redding, Spencer Bullock, Delia Anstead, Gregory Agan, Brian K Marconi, Vincent C Barbieri, Sharon Sankar, Vidya Rebeles, Jennifer Flahive, Yvette Schoolfield, John Wang, Linding Lei, Xiufen Dow, Dorothy Yeh, Chih-Ko Dang, Howard Infante, Anthony J Gao, Shou-Jiang |
| description | BACKGROUND:Kaposiʼs sarcoma-associated herpesvirus (KSHV) seropositivity and lytic antibody titer are predictors for Kaposiʼs sarcoma.
METHODS:We examined demographic, viral, and immunologic factors that influence KSHV latent and lytic antibodies in HIV-infected patients.
RESULTS:Detection rate of KSHV latent but not lytic antibodies was lower in patients with CD4 cells/mm less than 200 than greater than 200 (odds ratio [OR], 0.26; 95% confidence interval [CI], 0.11-0.61) and CD8 cells/mm less than 400 than greater than 400 (OR, 0.26; 95% CI, 0.07-0.67). Overall seropositivity rate was higher in patients with CD4 cells/mm less than 200 than greater than 200 (OR, 2.34; 95% CI, 1.37-4.02) and HIV copies/mL greater than 400 than less than 400 (OR, 1.70; 95% CI, 1.09-2.65). Lytic antibody level was inversely correlated with CD4 count (P < 0.001). Lytic seropositivity (OR, 2.47; 95% CI, 1.35-4.50) and antibody level (adjusted difference mean optical density, 0.324; 95% CI, 0.16-0.46) were higher in patients with HIV infection greater than 15 than less than 15 years. Hispanics had higher lytic seropositivity rate (OR, 1.71; 95% CI, 1.07-2.73) and antibody level (adjusted difference mean optical density, 0.111; 95% CI, 0.03-0.18) than non-Hispanics.
CONCLUSIONS:Lower CD4 and CD8 counts impair antibody response to KSHV latent antigens. Immune deterioration, long-term HIV infection, and Hispanic status are risk factors for Kaposiʼs sarcoma predictors. |
| doi_str_mv | 10.1097/QAI.0b013e3181fdc928 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_904488185</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>904488185</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4908-6e0d634c57a321dc0b9ad2faa6b7a348e5941312fb23ebf084813740c8974f503</originalsourceid><addsrcrecordid>eNqFkcFu1DAQhiMEoqXwBghZSIhTih3biX1cVZSuWAko7TlynEnXbdYOHodqX4Vn4Ql4Kkx3AakHOM1o5vt_efwXxXNGjxnVzZtPi-Ux7SjjwJliQ291pR4Uh0wLUTZKiYe5l5UsBePyoHiCeE0pq4XQj4uDilEltG4Oi2_nDm_IqbEpRCRLP4wzeOv8FVn45LrQb8k54BQ8ApIUyHszBXQ_viP5bKING1MuEIN1JkFPziBOgF9dnJGs8sQnYnxPVtvk7J3fFXgkzpOPJrm8RXLpe4h3qwgphiw1I7lYQzTT9mnxaDAjwrN9PSouT99enJyVqw_vlieLVWmFpqqsgfY1F1Y2hlest7TTpq8GY-ouT4QCqfMXsGroKg7dkA9XjDeCWqUbMUjKj4rXO98phi8zYGo3Di2Mo_EQZmw1FUIppuR_SVUxqRutmky-vEdehzn6fEaGKilVXesMiR1kY0CMMLRTdBsTty2j7a-M25xxez_jLHux9567DfR_RL9DzcCrPWDQmnGIJieKfzneMEo1z5zacbdhTBDxZpxvIbZrMGNa__sNPwHBsMU1</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>822558669</pqid></control><display><type>article</type><title>Risk Factors Influencing Antibody Responses to Kaposiʼs Sarcoma-Associated Herpesvirus Latent and Lytic Antigens in Patients Under Antiretroviral Therapy</title><source>MEDLINE</source><source>Journals@Ovid LWW Legacy Archive</source><source>Free E- Journals</source><source>Journals@Ovid Complete</source><creator>Guadalupe, Moraima ; Pollock, Brad H ; Westbrook, Steven ; Redding, Spencer ; Bullock, Delia ; Anstead, Gregory ; Agan, Brian K ; Marconi, Vincent C ; Barbieri, Sharon ; Sankar, Vidya ; Rebeles, Jennifer ; Flahive, Yvette ; Schoolfield, John ; Wang, Linding ; Lei, Xiufen ; Dow, Dorothy ; Yeh, Chih-Ko ; Dang, Howard ; Infante, Anthony J ; Gao, Shou-Jiang</creator><creatorcontrib>Guadalupe, Moraima ; Pollock, Brad H ; Westbrook, Steven ; Redding, Spencer ; Bullock, Delia ; Anstead, Gregory ; Agan, Brian K ; Marconi, Vincent C ; Barbieri, Sharon ; Sankar, Vidya ; Rebeles, Jennifer ; Flahive, Yvette ; Schoolfield, John ; Wang, Linding ; Lei, Xiufen ; Dow, Dorothy ; Yeh, Chih-Ko ; Dang, Howard ; Infante, Anthony J ; Gao, Shou-Jiang</creatorcontrib><description>BACKGROUND:Kaposiʼs sarcoma-associated herpesvirus (KSHV) seropositivity and lytic antibody titer are predictors for Kaposiʼs sarcoma.
METHODS:We examined demographic, viral, and immunologic factors that influence KSHV latent and lytic antibodies in HIV-infected patients.
RESULTS:Detection rate of KSHV latent but not lytic antibodies was lower in patients with CD4 cells/mm less than 200 than greater than 200 (odds ratio [OR], 0.26; 95% confidence interval [CI], 0.11-0.61) and CD8 cells/mm less than 400 than greater than 400 (OR, 0.26; 95% CI, 0.07-0.67). Overall seropositivity rate was higher in patients with CD4 cells/mm less than 200 than greater than 200 (OR, 2.34; 95% CI, 1.37-4.02) and HIV copies/mL greater than 400 than less than 400 (OR, 1.70; 95% CI, 1.09-2.65). Lytic antibody level was inversely correlated with CD4 count (P < 0.001). Lytic seropositivity (OR, 2.47; 95% CI, 1.35-4.50) and antibody level (adjusted difference mean optical density, 0.324; 95% CI, 0.16-0.46) were higher in patients with HIV infection greater than 15 than less than 15 years. Hispanics had higher lytic seropositivity rate (OR, 1.71; 95% CI, 1.07-2.73) and antibody level (adjusted difference mean optical density, 0.111; 95% CI, 0.03-0.18) than non-Hispanics.
CONCLUSIONS:Lower CD4 and CD8 counts impair antibody response to KSHV latent antigens. Immune deterioration, long-term HIV infection, and Hispanic status are risk factors for Kaposiʼs sarcoma predictors.</description><identifier>ISSN: 1525-4135</identifier><identifier>EISSN: 1944-7884</identifier><identifier>DOI: 10.1097/QAI.0b013e3181fdc928</identifier><identifier>PMID: 21084997</identifier><identifier>CODEN: JDSRET</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins, Inc</publisher><subject>Adult ; AIDS-Related Opportunistic Infections - immunology ; AIDS/HIV ; Anti-HIV Agents - therapeutic use ; Antibodies, Viral - blood ; Antibodies, Viral - immunology ; Antibody Formation - immunology ; Antigens ; Antigens, Viral - blood ; Antigens, Viral - immunology ; Antiretroviral drugs ; Antiretroviral Therapy, Highly Active ; Biological and medical sciences ; CD4 Lymphocyte Count ; CD4-CD8 Ratio ; Cells ; Drug therapy ; Female ; Fundamental and applied biological sciences. Psychology ; Herpes viruses ; Herpesvirus 8, Human - immunology ; Herpesvirus 8, Human - physiology ; HIV ; Human herpesvirus 8 ; Human immunodeficiency virus ; Human viral diseases ; Humans ; Infectious diseases ; Kaposi's sarcoma-associated herpesvirus ; Kaposis sarcoma ; Male ; Medical sciences ; Microbiology ; Middle Aged ; Miscellaneous ; Multivariate Analysis ; Patients ; Risk Factors ; Sarcoma, Kaposi - immunology ; Sarcoma, Kaposi - virology ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Viral Load - immunology ; Virology ; Virus Latency - immunology</subject><ispartof>Journal of acquired immune deficiency syndromes (1999), 2011-01, Vol.56 (1), p.83-90</ispartof><rights>2011 Lippincott Williams & Wilkins, Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright Lippincott Williams & Wilkins Jan 1, 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4908-6e0d634c57a321dc0b9ad2faa6b7a348e5941312fb23ebf084813740c8974f503</citedby><cites>FETCH-LOGICAL-c4908-6e0d634c57a321dc0b9ad2faa6b7a348e5941312fb23ebf084813740c8974f503</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23710093$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21084997$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guadalupe, Moraima</creatorcontrib><creatorcontrib>Pollock, Brad H</creatorcontrib><creatorcontrib>Westbrook, Steven</creatorcontrib><creatorcontrib>Redding, Spencer</creatorcontrib><creatorcontrib>Bullock, Delia</creatorcontrib><creatorcontrib>Anstead, Gregory</creatorcontrib><creatorcontrib>Agan, Brian K</creatorcontrib><creatorcontrib>Marconi, Vincent C</creatorcontrib><creatorcontrib>Barbieri, Sharon</creatorcontrib><creatorcontrib>Sankar, Vidya</creatorcontrib><creatorcontrib>Rebeles, Jennifer</creatorcontrib><creatorcontrib>Flahive, Yvette</creatorcontrib><creatorcontrib>Schoolfield, John</creatorcontrib><creatorcontrib>Wang, Linding</creatorcontrib><creatorcontrib>Lei, Xiufen</creatorcontrib><creatorcontrib>Dow, Dorothy</creatorcontrib><creatorcontrib>Yeh, Chih-Ko</creatorcontrib><creatorcontrib>Dang, Howard</creatorcontrib><creatorcontrib>Infante, Anthony J</creatorcontrib><creatorcontrib>Gao, Shou-Jiang</creatorcontrib><title>Risk Factors Influencing Antibody Responses to Kaposiʼs Sarcoma-Associated Herpesvirus Latent and Lytic Antigens in Patients Under Antiretroviral Therapy</title><title>Journal of acquired immune deficiency syndromes (1999)</title><addtitle>J Acquir Immune Defic Syndr</addtitle><description>BACKGROUND:Kaposiʼs sarcoma-associated herpesvirus (KSHV) seropositivity and lytic antibody titer are predictors for Kaposiʼs sarcoma.
METHODS:We examined demographic, viral, and immunologic factors that influence KSHV latent and lytic antibodies in HIV-infected patients.
RESULTS:Detection rate of KSHV latent but not lytic antibodies was lower in patients with CD4 cells/mm less than 200 than greater than 200 (odds ratio [OR], 0.26; 95% confidence interval [CI], 0.11-0.61) and CD8 cells/mm less than 400 than greater than 400 (OR, 0.26; 95% CI, 0.07-0.67). Overall seropositivity rate was higher in patients with CD4 cells/mm less than 200 than greater than 200 (OR, 2.34; 95% CI, 1.37-4.02) and HIV copies/mL greater than 400 than less than 400 (OR, 1.70; 95% CI, 1.09-2.65). Lytic antibody level was inversely correlated with CD4 count (P < 0.001). Lytic seropositivity (OR, 2.47; 95% CI, 1.35-4.50) and antibody level (adjusted difference mean optical density, 0.324; 95% CI, 0.16-0.46) were higher in patients with HIV infection greater than 15 than less than 15 years. Hispanics had higher lytic seropositivity rate (OR, 1.71; 95% CI, 1.07-2.73) and antibody level (adjusted difference mean optical density, 0.111; 95% CI, 0.03-0.18) than non-Hispanics.
CONCLUSIONS:Lower CD4 and CD8 counts impair antibody response to KSHV latent antigens. Immune deterioration, long-term HIV infection, and Hispanic status are risk factors for Kaposiʼs sarcoma predictors.</description><subject>Adult</subject><subject>AIDS-Related Opportunistic Infections - immunology</subject><subject>AIDS/HIV</subject><subject>Anti-HIV Agents - therapeutic use</subject><subject>Antibodies, Viral - blood</subject><subject>Antibodies, Viral - immunology</subject><subject>Antibody Formation - immunology</subject><subject>Antigens</subject><subject>Antigens, Viral - blood</subject><subject>Antigens, Viral - immunology</subject><subject>Antiretroviral drugs</subject><subject>Antiretroviral Therapy, Highly Active</subject><subject>Biological and medical sciences</subject><subject>CD4 Lymphocyte Count</subject><subject>CD4-CD8 Ratio</subject><subject>Cells</subject><subject>Drug therapy</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Herpes viruses</subject><subject>Herpesvirus 8, Human - immunology</subject><subject>Herpesvirus 8, Human - physiology</subject><subject>HIV</subject><subject>Human herpesvirus 8</subject><subject>Human immunodeficiency virus</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Kaposi's sarcoma-associated herpesvirus</subject><subject>Kaposis sarcoma</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbiology</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Multivariate Analysis</subject><subject>Patients</subject><subject>Risk Factors</subject><subject>Sarcoma, Kaposi - immunology</subject><subject>Sarcoma, Kaposi - virology</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. Aids</subject><subject>Viral Load - immunology</subject><subject>Virology</subject><subject>Virus Latency - immunology</subject><issn>1525-4135</issn><issn>1944-7884</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFu1DAQhiMEoqXwBghZSIhTih3biX1cVZSuWAko7TlynEnXbdYOHodqX4Vn4Ql4Kkx3AakHOM1o5vt_efwXxXNGjxnVzZtPi-Ux7SjjwJliQ291pR4Uh0wLUTZKiYe5l5UsBePyoHiCeE0pq4XQj4uDilEltG4Oi2_nDm_IqbEpRCRLP4wzeOv8FVn45LrQb8k54BQ8ApIUyHszBXQ_viP5bKING1MuEIN1JkFPziBOgF9dnJGs8sQnYnxPVtvk7J3fFXgkzpOPJrm8RXLpe4h3qwgphiw1I7lYQzTT9mnxaDAjwrN9PSouT99enJyVqw_vlieLVWmFpqqsgfY1F1Y2hlest7TTpq8GY-ouT4QCqfMXsGroKg7dkA9XjDeCWqUbMUjKj4rXO98phi8zYGo3Di2Mo_EQZmw1FUIppuR_SVUxqRutmky-vEdehzn6fEaGKilVXesMiR1kY0CMMLRTdBsTty2j7a-M25xxez_jLHux9567DfR_RL9DzcCrPWDQmnGIJieKfzneMEo1z5zacbdhTBDxZpxvIbZrMGNa__sNPwHBsMU1</recordid><startdate>20110101</startdate><enddate>20110101</enddate><creator>Guadalupe, Moraima</creator><creator>Pollock, Brad H</creator><creator>Westbrook, Steven</creator><creator>Redding, Spencer</creator><creator>Bullock, Delia</creator><creator>Anstead, Gregory</creator><creator>Agan, Brian K</creator><creator>Marconi, Vincent C</creator><creator>Barbieri, Sharon</creator><creator>Sankar, Vidya</creator><creator>Rebeles, Jennifer</creator><creator>Flahive, Yvette</creator><creator>Schoolfield, John</creator><creator>Wang, Linding</creator><creator>Lei, Xiufen</creator><creator>Dow, Dorothy</creator><creator>Yeh, Chih-Ko</creator><creator>Dang, Howard</creator><creator>Infante, Anthony J</creator><creator>Gao, Shou-Jiang</creator><general>Lippincott Williams & Wilkins, Inc</general><general>Lippincott Williams & Wilkins</general><general>Lippincott Williams & Wilkins Ovid Technologies</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7T5</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20110101</creationdate><title>Risk Factors Influencing Antibody Responses to Kaposiʼs Sarcoma-Associated Herpesvirus Latent and Lytic Antigens in Patients Under Antiretroviral Therapy</title><author>Guadalupe, Moraima ; Pollock, Brad H ; Westbrook, Steven ; Redding, Spencer ; Bullock, Delia ; Anstead, Gregory ; Agan, Brian K ; Marconi, Vincent C ; Barbieri, Sharon ; Sankar, Vidya ; Rebeles, Jennifer ; Flahive, Yvette ; Schoolfield, John ; Wang, Linding ; Lei, Xiufen ; Dow, Dorothy ; Yeh, Chih-Ko ; Dang, Howard ; Infante, Anthony J ; Gao, Shou-Jiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4908-6e0d634c57a321dc0b9ad2faa6b7a348e5941312fb23ebf084813740c8974f503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>AIDS-Related Opportunistic Infections - immunology</topic><topic>AIDS/HIV</topic><topic>Anti-HIV Agents - therapeutic use</topic><topic>Antibodies, Viral - blood</topic><topic>Antibodies, Viral - immunology</topic><topic>Antibody Formation - immunology</topic><topic>Antigens</topic><topic>Antigens, Viral - blood</topic><topic>Antigens, Viral - immunology</topic><topic>Antiretroviral drugs</topic><topic>Antiretroviral Therapy, Highly Active</topic><topic>Biological and medical sciences</topic><topic>CD4 Lymphocyte Count</topic><topic>CD4-CD8 Ratio</topic><topic>Cells</topic><topic>Drug therapy</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Herpes viruses</topic><topic>Herpesvirus 8, Human - immunology</topic><topic>Herpesvirus 8, Human - physiology</topic><topic>HIV</topic><topic>Human herpesvirus 8</topic><topic>Human immunodeficiency virus</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Kaposi's sarcoma-associated herpesvirus</topic><topic>Kaposis sarcoma</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbiology</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Multivariate Analysis</topic><topic>Patients</topic><topic>Risk Factors</topic><topic>Sarcoma, Kaposi - immunology</topic><topic>Sarcoma, Kaposi - virology</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. Aids</topic><topic>Viral Load - immunology</topic><topic>Virology</topic><topic>Virus Latency - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guadalupe, Moraima</creatorcontrib><creatorcontrib>Pollock, Brad H</creatorcontrib><creatorcontrib>Westbrook, Steven</creatorcontrib><creatorcontrib>Redding, Spencer</creatorcontrib><creatorcontrib>Bullock, Delia</creatorcontrib><creatorcontrib>Anstead, Gregory</creatorcontrib><creatorcontrib>Agan, Brian K</creatorcontrib><creatorcontrib>Marconi, Vincent C</creatorcontrib><creatorcontrib>Barbieri, Sharon</creatorcontrib><creatorcontrib>Sankar, Vidya</creatorcontrib><creatorcontrib>Rebeles, Jennifer</creatorcontrib><creatorcontrib>Flahive, Yvette</creatorcontrib><creatorcontrib>Schoolfield, John</creatorcontrib><creatorcontrib>Wang, Linding</creatorcontrib><creatorcontrib>Lei, Xiufen</creatorcontrib><creatorcontrib>Dow, Dorothy</creatorcontrib><creatorcontrib>Yeh, Chih-Ko</creatorcontrib><creatorcontrib>Dang, Howard</creatorcontrib><creatorcontrib>Infante, Anthony J</creatorcontrib><creatorcontrib>Gao, Shou-Jiang</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of acquired immune deficiency syndromes (1999)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guadalupe, Moraima</au><au>Pollock, Brad H</au><au>Westbrook, Steven</au><au>Redding, Spencer</au><au>Bullock, Delia</au><au>Anstead, Gregory</au><au>Agan, Brian K</au><au>Marconi, Vincent C</au><au>Barbieri, Sharon</au><au>Sankar, Vidya</au><au>Rebeles, Jennifer</au><au>Flahive, Yvette</au><au>Schoolfield, John</au><au>Wang, Linding</au><au>Lei, Xiufen</au><au>Dow, Dorothy</au><au>Yeh, Chih-Ko</au><au>Dang, Howard</au><au>Infante, Anthony J</au><au>Gao, Shou-Jiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk Factors Influencing Antibody Responses to Kaposiʼs Sarcoma-Associated Herpesvirus Latent and Lytic Antigens in Patients Under Antiretroviral Therapy</atitle><jtitle>Journal of acquired immune deficiency syndromes (1999)</jtitle><addtitle>J Acquir Immune Defic Syndr</addtitle><date>2011-01-01</date><risdate>2011</risdate><volume>56</volume><issue>1</issue><spage>83</spage><epage>90</epage><pages>83-90</pages><issn>1525-4135</issn><eissn>1944-7884</eissn><coden>JDSRET</coden><abstract>BACKGROUND:Kaposiʼs sarcoma-associated herpesvirus (KSHV) seropositivity and lytic antibody titer are predictors for Kaposiʼs sarcoma.
METHODS:We examined demographic, viral, and immunologic factors that influence KSHV latent and lytic antibodies in HIV-infected patients.
RESULTS:Detection rate of KSHV latent but not lytic antibodies was lower in patients with CD4 cells/mm less than 200 than greater than 200 (odds ratio [OR], 0.26; 95% confidence interval [CI], 0.11-0.61) and CD8 cells/mm less than 400 than greater than 400 (OR, 0.26; 95% CI, 0.07-0.67). Overall seropositivity rate was higher in patients with CD4 cells/mm less than 200 than greater than 200 (OR, 2.34; 95% CI, 1.37-4.02) and HIV copies/mL greater than 400 than less than 400 (OR, 1.70; 95% CI, 1.09-2.65). Lytic antibody level was inversely correlated with CD4 count (P < 0.001). Lytic seropositivity (OR, 2.47; 95% CI, 1.35-4.50) and antibody level (adjusted difference mean optical density, 0.324; 95% CI, 0.16-0.46) were higher in patients with HIV infection greater than 15 than less than 15 years. Hispanics had higher lytic seropositivity rate (OR, 1.71; 95% CI, 1.07-2.73) and antibody level (adjusted difference mean optical density, 0.111; 95% CI, 0.03-0.18) than non-Hispanics.
CONCLUSIONS:Lower CD4 and CD8 counts impair antibody response to KSHV latent antigens. Immune deterioration, long-term HIV infection, and Hispanic status are risk factors for Kaposiʼs sarcoma predictors.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins, Inc</pub><pmid>21084997</pmid><doi>10.1097/QAI.0b013e3181fdc928</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1525-4135 |
| ispartof | Journal of acquired immune deficiency syndromes (1999), 2011-01, Vol.56 (1), p.83-90 |
| issn | 1525-4135 1944-7884 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_904488185 |
| source | MEDLINE; Journals@Ovid LWW Legacy Archive; Free E- Journals; Journals@Ovid Complete |
| subjects | Adult AIDS-Related Opportunistic Infections - immunology AIDS/HIV Anti-HIV Agents - therapeutic use Antibodies, Viral - blood Antibodies, Viral - immunology Antibody Formation - immunology Antigens Antigens, Viral - blood Antigens, Viral - immunology Antiretroviral drugs Antiretroviral Therapy, Highly Active Biological and medical sciences CD4 Lymphocyte Count CD4-CD8 Ratio Cells Drug therapy Female Fundamental and applied biological sciences. Psychology Herpes viruses Herpesvirus 8, Human - immunology Herpesvirus 8, Human - physiology HIV Human herpesvirus 8 Human immunodeficiency virus Human viral diseases Humans Infectious diseases Kaposi's sarcoma-associated herpesvirus Kaposis sarcoma Male Medical sciences Microbiology Middle Aged Miscellaneous Multivariate Analysis Patients Risk Factors Sarcoma, Kaposi - immunology Sarcoma, Kaposi - virology Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral Load - immunology Virology Virus Latency - immunology |
| title | Risk Factors Influencing Antibody Responses to Kaposiʼs Sarcoma-Associated Herpesvirus Latent and Lytic Antigens in Patients Under Antiretroviral Therapy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T21%3A09%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Risk%20Factors%20Influencing%20Antibody%20Responses%20to%20Kaposi%CA%BCs%20Sarcoma-Associated%20Herpesvirus%20Latent%20and%20Lytic%20Antigens%20in%20Patients%20Under%20Antiretroviral%20Therapy&rft.jtitle=Journal%20of%20acquired%20immune%20deficiency%20syndromes%20(1999)&rft.au=Guadalupe,%20Moraima&rft.date=2011-01-01&rft.volume=56&rft.issue=1&rft.spage=83&rft.epage=90&rft.pages=83-90&rft.issn=1525-4135&rft.eissn=1944-7884&rft.coden=JDSRET&rft_id=info:doi/10.1097/QAI.0b013e3181fdc928&rft_dat=%3Cproquest_cross%3E904488185%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=822558669&rft_id=info:pmid/21084997&rfr_iscdi=true |