IgG autoantibodies against deposited C3 inhibit macrophage-mediated apoptotic cell engulfment in systemic autoimmunity

Defective clearance of apoptotic cells has been shown in systemic lupus erythematosus (SLE) and is postulated to enhance autoimmune responses by increasing access to intracellular autoantigens. Until now, research has emphasized inherited rather than acquired impairment of apoptotic cell engulfment...

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Veröffentlicht in:	The Journal of immunology (1950) 2011-09, Vol.187 (5), p.2101-2111
Hauptverfasser:	Kenyon, Karla D, Cole, Caroline, Crawford, Fran, Kappler, John W, Thurman, Joshua M, Bratton, Donna L, Boackle, Susan A, Henson, Peter M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Autoantibodies - immunology Autoantigens - immunology Complement C3 - immunology Disease Models, Animal Enzyme-Linked Immunosorbent Assay Humans Immunoglobulin G - immunology Lupus Erythematosus, Systemic - immunology Lupus Erythematosus, Systemic - pathology Macrophages - immunology Mice Phagocytosis - immunology
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