Dopamine D2 Receptor Occupancy and Clinical Effects: A Systematic Review and Pooled Analysis

Positron emission tomography (PET) studies proposed a therapeutic window of D2 receptor occupancy (65%-80%) of antipsychotics for the treatment of schizophrenia in young adults. However, this conclusion has been drawn from clinical PET studies using small sample sizes (

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of clinical psychopharmacology 2011-08, Vol.31 (4), p.497-502
Hauptverfasser:	UCHIDA, Hiroyuki, TAKEUCHI, Hiroyoshi, GRAFF-GUERRERO, Ariel, SUZUKI, Takefumi, WATANABE, Koichiro, MAMO, David C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antipsychotic Agents - metabolism Antipsychotic Agents - therapeutic use Biological and medical sciences Brain - diagnostic imaging Brain - metabolism Clinical Trials as Topic - methods Humans Medical sciences Neuropharmacology Pharmacology. Drug treatments Positron-Emission Tomography - methods Receptors, Dopamine D2 - metabolism Receptors, Dopamine D2 - physiology Schizophrenia - diagnostic imaging Schizophrenia - drug therapy Schizophrenia - metabolism Treatment Outcome
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Beschreibung
Zusammenfassung:	Positron emission tomography (PET) studies proposed a therapeutic window of D2 receptor occupancy (65%-80%) of antipsychotics for the treatment of schizophrenia in young adults. However, this conclusion has been drawn from clinical PET studies using small sample sizes (
ISSN:	0271-0749 1533-712X
DOI:	10.1097/JCP.0b013e3182214aad