The novel δ opioid receptor agonist KNT-127 produces antidepressant-like and antinociceptive effects in mice without producing convulsions

► A novel δ opioid receptor (DOP) agonist KNT-127 produced no convulsions in mice. ► KNT-127 produced antidepressant-like effects in mice forced swim test. ► KNT-127 produced antinociceptive effects in mice writhing and/or formalin tests. ► These pharmacological effects were completely reversed by N...

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Veröffentlicht in:	Behavioural brain research 2011-10, Vol.223 (2), p.271-279
Hauptverfasser:	Saitoh, Akiyoshi, Sugiyama, Azusa, Nemoto, Toru, Fujii, Hideaki, Wada, Keiji, Oka, Jun-Ichiro, Nagase, Hiroshi, Yamada, Mitsuhiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics Animals Antidepressants Antidepressive Agents Antidepressive Agents, Tricyclic - pharmacology Behavior, Animal - drug effects Benzamides - pharmacology Depression - prevention & control Depression - psychology Dopamine Antagonists - pharmacology Forced swim test Formalin test Imipramine - pharmacology KNT-127 Male Mice Mice, Inbred ICR Morphinans - pharmacology Motor Activity - drug effects Naltrexone - analogs & derivatives Naltrexone - pharmacology Narcotic Antagonists - pharmacology Opioid delta subtype Pain Measurement - drug effects Piperazines - pharmacology Receptors, Opioid, delta - agonists Seizures - chemically induced Swimming - psychology Writhing test
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