Nanostructure formation in aqueous solution of amphiphilic copolymers of 2-( N, N-dimethylaminoethyl)methacrylate and alkylacrylate: Characterization, antimicrobial activity, DNA binding, and cytotoxicity studies

Three amphiphilic random copolymers poly(2-(dimethylaminoethyl)methacrylate-co-alkylacrylate) (where, alkyl = hexyl, octyl, dodecyl) with 16 mol% hydrophobic substitution were synthesized. Surface tension, viscosity, fluorescence probe, dynamic light scattering (DLS), as well as transmission electro...

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Veröffentlicht in:	International journal of pharmaceutics 2011-07, Vol.414 (1), p.298-311
Hauptverfasser:	Dutta, Pranabesh, Dey, Joykrishna, Shome, Anshupriya, Das, Prasanta Kumar
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Acrylates - analysis Acrylates - chemical synthesis Acrylates - toxicity Animals Anti-Infective Agents - analysis Anti-Infective Agents - chemical synthesis Anti-Infective Agents - toxicity Antimicrobial activity Bacillus subtilis Biocompatibility Biological and medical sciences Cell Survival - drug effects Cytotoxins - chemistry Cytotoxins - toxicity DNA - analysis DNA - genetics DNA binding Drug Carriers Drug Compounding Drug Delivery Systems Escherichia coli General pharmacology Hydrophobically modified polymer Indicators and Reagents - analysis Indicators and Reagents - metabolism Male Medical sciences Methacrylates - chemistry Methacrylates - toxicity Mice Mice, Inbred BALB C Microbial Sensitivity Tests Nanostructures - chemistry Nanostructures - toxicity Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polymers - chemistry Surface Properties Transmission electron microscopy Viscosity Water
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