MicroRNA profiling of clear cell renal cell carcinoma by whole-genome small RNA deep sequencing of paired frozen and formalin-fixed, paraffin-embedded tissue specimens

Renal cell carcinoma (RCC) is one of the leading causes of cancer mortality. Characterization of microRNA (miRNA) expression of RCC will help disclose new pathogenic pathways in tumourigenesis and progression and may lead to the development of molecular biomarkers and target-specific therapies for d...

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Veröffentlicht in:	The Journal of pathology 2010-09, Vol.222 (1), p.41-51
Hauptverfasser:	Weng, Lihong, Wu, Xiwei, Gao, Hanlin, Mu, Bing, Li, Xuejun, Wang, Jin-Hui, Guo, Chao, Jin, Jennifer M, Chen, Zhuo, Covarrubias, Maricela, Yuan, Yate-Ching, Weiss, Lawrence M, Wu, Huiqing
Format:	Artikel
Sprache:	eng
Schlagworte:	Benign Biological and medical sciences biomarkers Carcinoma, Renal Cell - genetics Clear cells Cluster Analysis Cryopreservation Formaldehyde formalin-fixed paraffin-embedded (FFPE) Gene Expression Profiling - methods Gene Expression Regulation, Neoplastic Humans Investigative techniques, diagnostic techniques (general aspects) Kidney Neoplasms - genetics Kidneys Medical sciences microarray MicroRNAs - genetics miRNA Mortality Nephrology. Urinary tract diseases next-generation sequencing non-coding RNA Oligonucleotide Array Sequence Analysis - methods Paraffin Embedding Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Polymerase chain reaction renal cell carcinoma Reverse Transcriptase Polymerase Chain Reaction - methods RNA, Neoplasm - genetics RT-PCR small RNA deep sequencing (smRNA-seq) Tissue Fixation - methods Tumors of the urinary system
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