CD8 super(+) T-cell lymphoproliferative disorder associated with Epstein-Barr virus in a patient with rheumatoid arthritis during methotrexate therapy
A 75-year-old woman with rheumatoid arthritis (RA) who was receiving methotrexate (MTX) therapy developed Epstein-Barr virus (EBV)-associated CD8 super(+) T-cell lymphoproliferative disorder (LPD) and meningoencephalitis. She was successfully treated with acyclovir and corticosteroids plus MTX cessa...
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Veröffentlicht in: | Modern rheumatology 2010-10, Vol.20 (5), p.500-505 |
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creator | Hatachi, Saori Kunitomi, Akane Aozasa, Katsuyuki Yagita, Masato |
description | A 75-year-old woman with rheumatoid arthritis (RA) who was receiving methotrexate (MTX) therapy developed Epstein-Barr virus (EBV)-associated CD8 super(+) T-cell lymphoproliferative disorder (LPD) and meningoencephalitis. She was successfully treated with acyclovir and corticosteroids plus MTX cessation. T-cell LPD is relatively rare in RA patients receiving MTX. To our knowledge, this is the first report of CD8 super(+) T-cell LPD with EBV genome occurring during MTX therapy for RA. EBV infection should be carefully monitored to assess severe EBV-associated complications. |
doi_str_mv | 10.1007/s10165-010-0300-z |
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source | Oxford University Press Journals All Titles (1996-Current); SpringerLink Journals - AutoHoldings |
subjects | Epstein-Barr virus |
title | CD8 super(+) T-cell lymphoproliferative disorder associated with Epstein-Barr virus in a patient with rheumatoid arthritis during methotrexate therapy |
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