Ligation of Notch receptors in human conventional and plasmacytoid dendritic cells differentially regulates cytokine and chemokine secretion and modulates Th cell polarization

Notch signaling is involved in multiple cellular processes. Recent data also support the prominent role of Notch signaling in the regulation of the immune response. In this study, we analyzed the expression and function of Notch receptors and ligands on both human blood conventional dendritic cells...

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Veröffentlicht in:	The Journal of immunology (1950) 2011-06, Vol.186 (12), p.7006-7015
Hauptverfasser:	Pérez-Cabezas, Begoña, Naranjo-Gómez, Mar, Bastos-Amador, Patricia, Requena-Fernández, Gerard, Pujol-Borrell, Ricardo, Borràs, Francesc E
Format:	Artikel
Sprache:	eng
Schlagworte:	Blood Cells Chemokines - secretion Cytokines - secretion Dendritic Cells - classification Dendritic Cells - immunology Epithelial Cells Humans Receptors, Notch - immunology Receptors, Notch - metabolism Signal Transduction - immunology T-Lymphocytes, Helper-Inducer - immunology
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