Cyclophilin A is a damage-associated molecular pattern molecule that mediates acetaminophen-induced liver injury

The immune system is alerted to cell death by molecules known as damage-associated molecular patterns (DAMPs). These molecules partly mediate acetaminophen-induced liver injury, an archetypal experimental model of sterile cell death and the commonest cause of acute liver failure in the western world...

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Veröffentlicht in:	The Journal of immunology (1950) 2011-09, Vol.187 (6), p.3347-3352
Hauptverfasser:	Dear, James W, Simpson, Kenneth J, Nicolai, Melianthe P J, Catterson, James H, Street, Jonathan, Huizinga, Tineke, Craig, Darren G, Dhaliwal, Kevin, Webb, Sheila, Bateman, D Nicholas, Webb, David J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen - adverse effects Analgesics, Non-Narcotic - adverse effects Animals Chemical and Drug Induced Liver Injury - immunology Chemical and Drug Induced Liver Injury - metabolism Cyclophilin A - immunology Cyclophilin A - metabolism Humans Mice Mice, Knockout
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