Immunogenicity of novel nanoparticle-coated MSP-1 C-terminus malaria DNA vaccine using different routes of administration

Highlights ► Nanoparticle as gene-carrier substantially provoked antigen driven immune response. ► We observed the stimulatory effect of nanoparticle coating without an adjuvant. ► Better protection was observed to be in the following order i.p. > i.v. > s.c.

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Bibliographische Detailangaben
Veröffentlicht in:	Vaccine 2011-11, Vol.29 (48), p.9038-9050
Hauptverfasser:	Cherif, Mahamoud Sama, Shuaibu, Mohammed Nasir, Kurosaki, Tomoaki, Helegbe, Gideon Kofi, Kikuchi, Mihoko, Yanagi, Tetsuo, Tsuboi, Takafumi, Sasaki, Hitoshi, Hirayama, Kenji
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology animal models Animals Antibodies, Protozoan - blood antibody formation antigens Applied microbiology Biological and medical sciences blood serum CD4-Positive T-Lymphocytes - immunology CD8-positive T-lymphocytes CD8-Positive T-Lymphocytes - immunology Cytokines Cytokines - immunology Delivery system Deoxyribonucleic acid Disease DNA DNA vaccine Female Fundamental and applied biological sciences. Psychology Human protozoal diseases Immune response Immunogenicity immunoglobulin G Infections Infectious diseases Injections, Intraperitoneal Injections, Intravenous Injections, Subcutaneous interferon-gamma interleukin-12 intravenous injection Malaria Malaria - prevention & control Malaria Vaccines - administration & dosage Malaria Vaccines - immunology Medical sciences Merozoite Surface Protein 1 - immunology Mice Mice, Inbred C57BL Microbiology Mortality MSP1 Nanoparticle nanoparticles Nanoparticles - administration & dosage Parasitic diseases Plasmids Plasmids - administration & dosage Plasmids - immunology Plasmodium yoelii Plasmodium yoelii - immunology Protozoal diseases recombinant vaccines Routes administration Spleen - cytology Spleen - immunology splenocytes transfection vaccination Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, DNA - administration & dosage Vaccines, DNA - immunology Vector-borne diseases
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Beschreibung
Zusammenfassung:	Highlights ► Nanoparticle as gene-carrier substantially provoked antigen driven immune response. ► We observed the stimulatory effect of nanoparticle coating without an adjuvant. ► Better protection was observed to be in the following order i.p. > i.v. > s.c.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2011.09.031