A Mammalian Herpesvirus Uses Noncanonical Expression and Processing Mechanisms to Generate Viral MicroRNAs

Canonical primary microRNA (pri-miRNA) precursors are transcribed by RNA polymerase II and then processed by the Drosha endonuclease to generate ∼60 nt pre-miRNA hairpins. Pre-miRNAs in turn are cleaved by Dicer to generate mature miRNAs. Previously, some short introns, called miRtrons, were reporte...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular cell 2010-01, Vol.37 (1), p.135-142
Hauptverfasser:	Bogerd, Hal P., Karnowski, Heather W., Cai, Xuezhong, Shin, Jinwook, Pohlers, Michael, Cullen, Bryan R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line Endoribonucleases - metabolism Herpesvirus Humans HUMDISEASE MicroRNAs - biosynthesis MicroRNAs - chemistry Nucleic Acid Conformation PROTEINS Rhadinovirus - genetics Ribonuclease III - metabolism RNA RNA Interference RNA Polymerase III - physiology RNA, Transfer - metabolism RNA, Viral - biosynthesis RNA, Viral - chemistry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!