Metabotropic Regulation of RhoA/Rho-Associated Kinase by L-type Ca2+ Channels: New Mechanism for Depolarization-Evoked Mammalian Arterial Contraction

BACKGROUND:Sustained vascular smooth muscle contraction is mediated by extracellular Ca influx through L-type voltage-gated Ca channels (VGCC) and RhoA/Rho-associated kinase (ROCK)-dependent Ca sensitization of the contractile machinery. VGCC activation can also trigger an ion-independent metabotrop...

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Veröffentlicht in:	Circulation research 2011-05, Vol.108 (11), p.1348-1357
Hauptverfasser:	Fernández-Tenorio, Miguel, Porras-González, Cristina, Castellano, Antonio, del Valle-Rodríguez, Alberto, López-Barneo, José, Ureña, Juan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basilar Artery - physiology Biological and medical sciences Blood vessels and receptors Calcium - metabolism Calcium Channel Blockers - pharmacology Calcium Channels, L-Type - genetics Calcium Channels, L-Type - physiology Coronary Vasospasm - physiopathology Electric Stimulation Enzyme Inhibitors - pharmacology Fundamental and applied biological sciences. Psychology Hypertension - physiopathology Indoles - pharmacology Mice Mice, Knockout Muscle Contraction - drug effects Muscle Contraction - physiology Muscle, Smooth, Vascular - physiology Nifedipine - pharmacology Phosphotransferases (Alcohol Group Acceptor) - metabolism Rabbits Rats rho GTP-Binding Proteins - antagonists & inhibitors rho GTP-Binding Proteins - metabolism rho-Associated Kinases - antagonists & inhibitors rho-Associated Kinases - metabolism Sarcoplasmic Reticulum - physiology Vasoconstriction - drug effects Vasoconstriction - physiology Vasospasm, Intracranial - physiopathology Vertebrates: cardiovascular system
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