Involvement of tyrosine kinase-2 in both the IL-12/Th1 and IL-23/Th17 axes in vivo

Tyrosine kinase-2 (Tyk2), a member of the Jak family of kinases, mediates the signals triggered by various cytokines, including type I IFNs, IL-12, and IL-23. In the current study, we investigated the in vivo involvement of Tyk2 in several IL-12/Th1- and IL-23/Th17-mediated models of experimental di...

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Veröffentlicht in:	The Journal of immunology (1950) 2011-07, Vol.187 (1), p.181-189
Hauptverfasser:	Ishizaki, Masayuki, Akimoto, Toshihiko, Muromoto, Ryuta, Yokoyama, Mika, Ohshiro, Yuya, Sekine, Yuichi, Maeda, Hiroaki, Shimoda, Kazuya, Oritani, Kenji, Matsuda, Tadashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - toxicity Aminoquinolines - toxicity Animals Cell Differentiation - genetics Colitis - chemically induced Colitis - enzymology Colitis - immunology Dextran Sulfate - administration & dosage Drug Delivery Systems - methods Hypersensitivity, Delayed - enzymology Hypersensitivity, Delayed - immunology Interleukin-12 - physiology Interleukin-23 - physiology Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Psoriasis - chemically induced Psoriasis - enzymology Psoriasis - immunology Th1 Cells - cytology Th1 Cells - enzymology Th1 Cells - immunology Th17 Cells - cytology Th17 Cells - enzymology Th17 Cells - immunology Trinitrobenzenesulfonic Acid - administration & dosage TYK2 Kinase - deficiency TYK2 Kinase - genetics TYK2 Kinase - physiology
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