Involvement of tyrosine kinase-2 in both the IL-12/Th1 and IL-23/Th17 axes in vivo
Tyrosine kinase-2 (Tyk2), a member of the Jak family of kinases, mediates the signals triggered by various cytokines, including type I IFNs, IL-12, and IL-23. In the current study, we investigated the in vivo involvement of Tyk2 in several IL-12/Th1- and IL-23/Th17-mediated models of experimental di...
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| Veröffentlicht in: | The Journal of immunology (1950) 2011-07, Vol.187 (1), p.181-189 |
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| container_title | The Journal of immunology (1950) |
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| creator | Ishizaki, Masayuki Akimoto, Toshihiko Muromoto, Ryuta Yokoyama, Mika Ohshiro, Yuya Sekine, Yuichi Maeda, Hiroaki Shimoda, Kazuya Oritani, Kenji Matsuda, Tadashi |
| description | Tyrosine kinase-2 (Tyk2), a member of the Jak family of kinases, mediates the signals triggered by various cytokines, including type I IFNs, IL-12, and IL-23. In the current study, we investigated the in vivo involvement of Tyk2 in several IL-12/Th1- and IL-23/Th17-mediated models of experimental diseases, including methylated BSA injection-induced footpad thickness, imiquimod-induced psoriasis-like skin inflammation, and dextran sulfate sodium- or 2,4,6-trinitrobenzene sulfonic acid-induced colitis. In these disease models, Tyk2 deficiency influenced the phenotypes in immunity and/or inflammation. Our findings demonstrate a somewhat broader contribution of Tyk2 to immune systems than previously expected and suggest that Tyk2 may represent an important candidate for drug development by targeting both the IL-12/Th1 and IL-23/Th17 axes. |
| doi_str_mv | 10.4049/jimmunol.1003244 |
| format | Article |
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Our findings demonstrate a somewhat broader contribution of Tyk2 to immune systems than previously expected and suggest that Tyk2 may represent an important candidate for drug development by targeting both the IL-12/Th1 and IL-23/Th17 axes.</description><subject>Adjuvants, Immunologic - toxicity</subject><subject>Aminoquinolines - toxicity</subject><subject>Animals</subject><subject>Cell Differentiation - genetics</subject><subject>Colitis - chemically induced</subject><subject>Colitis - enzymology</subject><subject>Colitis - immunology</subject><subject>Dextran Sulfate - administration & dosage</subject><subject>Drug Delivery Systems - methods</subject><subject>Hypersensitivity, Delayed - enzymology</subject><subject>Hypersensitivity, Delayed - immunology</subject><subject>Interleukin-12 - physiology</subject><subject>Interleukin-23 - physiology</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Inbred C57BL</subject><subject>Mice, Knockout</subject><subject>Psoriasis - chemically induced</subject><subject>Psoriasis - enzymology</subject><subject>Psoriasis - immunology</subject><subject>Th1 Cells - cytology</subject><subject>Th1 Cells - enzymology</subject><subject>Th1 Cells - immunology</subject><subject>Th17 Cells - cytology</subject><subject>Th17 Cells - enzymology</subject><subject>Th17 Cells - immunology</subject><subject>Trinitrobenzenesulfonic Acid - administration & dosage</subject><subject>TYK2 Kinase - deficiency</subject><subject>TYK2 Kinase - genetics</subject><subject>TYK2 Kinase - physiology</subject><issn>0022-1767</issn><issn>1550-6606</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtLw0AYRQdRbK3uXcnsXKX95pF5LKX4KBQE6T5MkhmamszUTBr035vQ1q2ry4Vz7-IgdE9gzoHrxa5qmoMP9ZwAMMr5BZqSNIVECBCXaApAaUKkkBN0E-MOAARQfo0mlAwA5XKKPla-D3VvG-s7HBzuftoQK2_xZ-VNtAnFlcd56La421q8WieELjZbgo0vx0bZ2CQ23zaOZF_14RZdOVNHe3fKGdq8PG-Wb8n6_XW1fFonBWeqS6TR0imdyjTNJS-JdJqLXBQy5YIacCVLtcxdrgvFjTNKa54XQwHqSscVm6HH4-2-DV8HG7usqWJh69p4Gw4x08C5ooLIf0klGSNCMT2QcCSLwUJsrcv2bdWY9icjkI3Gs7Px7GR8mDyczg95Y8u_wVkx-wUEv3sF</recordid><startdate>20110701</startdate><enddate>20110701</enddate><creator>Ishizaki, Masayuki</creator><creator>Akimoto, Toshihiko</creator><creator>Muromoto, Ryuta</creator><creator>Yokoyama, Mika</creator><creator>Ohshiro, Yuya</creator><creator>Sekine, Yuichi</creator><creator>Maeda, Hiroaki</creator><creator>Shimoda, Kazuya</creator><creator>Oritani, Kenji</creator><creator>Matsuda, Tadashi</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20110701</creationdate><title>Involvement of tyrosine kinase-2 in both the IL-12/Th1 and IL-23/Th17 axes in vivo</title><author>Ishizaki, Masayuki ; Akimoto, Toshihiko ; Muromoto, Ryuta ; Yokoyama, Mika ; Ohshiro, Yuya ; Sekine, Yuichi ; Maeda, Hiroaki ; Shimoda, Kazuya ; Oritani, Kenji ; Matsuda, Tadashi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-7a97f895755b74d17f946b6c75462a0fd3597bfb9c84afa8994bc9c802fdf483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adjuvants, Immunologic - toxicity</topic><topic>Aminoquinolines - toxicity</topic><topic>Animals</topic><topic>Cell Differentiation - genetics</topic><topic>Colitis - chemically induced</topic><topic>Colitis - enzymology</topic><topic>Colitis - immunology</topic><topic>Dextran Sulfate - administration & dosage</topic><topic>Drug Delivery Systems - methods</topic><topic>Hypersensitivity, Delayed - enzymology</topic><topic>Hypersensitivity, Delayed - immunology</topic><topic>Interleukin-12 - physiology</topic><topic>Interleukin-23 - physiology</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Inbred C57BL</topic><topic>Mice, Knockout</topic><topic>Psoriasis - chemically induced</topic><topic>Psoriasis - enzymology</topic><topic>Psoriasis - immunology</topic><topic>Th1 Cells - cytology</topic><topic>Th1 Cells - enzymology</topic><topic>Th1 Cells - immunology</topic><topic>Th17 Cells - cytology</topic><topic>Th17 Cells - enzymology</topic><topic>Th17 Cells - immunology</topic><topic>Trinitrobenzenesulfonic Acid - administration & dosage</topic><topic>TYK2 Kinase - deficiency</topic><topic>TYK2 Kinase - genetics</topic><topic>TYK2 Kinase - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ishizaki, Masayuki</creatorcontrib><creatorcontrib>Akimoto, Toshihiko</creatorcontrib><creatorcontrib>Muromoto, Ryuta</creatorcontrib><creatorcontrib>Yokoyama, Mika</creatorcontrib><creatorcontrib>Ohshiro, Yuya</creatorcontrib><creatorcontrib>Sekine, Yuichi</creatorcontrib><creatorcontrib>Maeda, Hiroaki</creatorcontrib><creatorcontrib>Shimoda, Kazuya</creatorcontrib><creatorcontrib>Oritani, Kenji</creatorcontrib><creatorcontrib>Matsuda, Tadashi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>The Journal of immunology (1950)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ishizaki, Masayuki</au><au>Akimoto, Toshihiko</au><au>Muromoto, Ryuta</au><au>Yokoyama, Mika</au><au>Ohshiro, Yuya</au><au>Sekine, Yuichi</au><au>Maeda, Hiroaki</au><au>Shimoda, Kazuya</au><au>Oritani, Kenji</au><au>Matsuda, Tadashi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Involvement of tyrosine kinase-2 in both the IL-12/Th1 and IL-23/Th17 axes in vivo</atitle><jtitle>The Journal of immunology (1950)</jtitle><addtitle>J Immunol</addtitle><date>2011-07-01</date><risdate>2011</risdate><volume>187</volume><issue>1</issue><spage>181</spage><epage>189</epage><pages>181-189</pages><issn>0022-1767</issn><eissn>1550-6606</eissn><abstract>Tyrosine kinase-2 (Tyk2), a member of the Jak family of kinases, mediates the signals triggered by various cytokines, including type I IFNs, IL-12, and IL-23. In the current study, we investigated the in vivo involvement of Tyk2 in several IL-12/Th1- and IL-23/Th17-mediated models of experimental diseases, including methylated BSA injection-induced footpad thickness, imiquimod-induced psoriasis-like skin inflammation, and dextran sulfate sodium- or 2,4,6-trinitrobenzene sulfonic acid-induced colitis. In these disease models, Tyk2 deficiency influenced the phenotypes in immunity and/or inflammation. Our findings demonstrate a somewhat broader contribution of Tyk2 to immune systems than previously expected and suggest that Tyk2 may represent an important candidate for drug development by targeting both the IL-12/Th1 and IL-23/Th17 axes.</abstract><cop>United States</cop><pmid>21606247</pmid><doi>10.4049/jimmunol.1003244</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of immunology (1950), 2011-07, Vol.187 (1), p.181-189 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adjuvants, Immunologic - toxicity Aminoquinolines - toxicity Animals Cell Differentiation - genetics Colitis - chemically induced Colitis - enzymology Colitis - immunology Dextran Sulfate - administration & dosage Drug Delivery Systems - methods Hypersensitivity, Delayed - enzymology Hypersensitivity, Delayed - immunology Interleukin-12 - physiology Interleukin-23 - physiology Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Psoriasis - chemically induced Psoriasis - enzymology Psoriasis - immunology Th1 Cells - cytology Th1 Cells - enzymology Th1 Cells - immunology Th17 Cells - cytology Th17 Cells - enzymology Th17 Cells - immunology Trinitrobenzenesulfonic Acid - administration & dosage TYK2 Kinase - deficiency TYK2 Kinase - genetics TYK2 Kinase - physiology |
| title | Involvement of tyrosine kinase-2 in both the IL-12/Th1 and IL-23/Th17 axes in vivo |
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