Evolutionary patterns of hepatitis B virus quasispecies under different selective pressures: correlation with antiviral efficacy

ObjectiveTo investigate the evolution of hepatitis B virus (HBV) quasispecies (QS) within the reverse transcriptase (RT) region during the early stage of entecavir treatment and its impact on virological response, and to compare evolutionary patterns under different selective pressures.Methods31 pat...

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Veröffentlicht in:	Gut 2011-09, Vol.60 (9), p.1269-1277
Hauptverfasser:	Liu, Feng, Chen, Li, Yu, De-Min, Deng, Lin, Chen, Rong, Jiang, Yin, Chen, Liang, Huang, Su-Yuan, Yu, Jia-Lun, Gong, Qi-Ming, Zhang, Xin-Xin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Antibiotics. Antiinfectious agents. Antiparasitic agents Antiretroviral drugs Antiviral agents Antiviral Agents - therapeutic use antiviral therapy Biological and medical sciences chronic/drug therapy/virology Clinical medicine Deoxyribonucleic acid DNA DNA, Viral - blood DNA, Viral - genetics Drug dosages Drug resistance Drug Resistance, Viral - genetics evolution Evolution, Molecular Female Gastroenterology. Liver. Pancreas. Abdomen genetic heterogeneity Genetic Variation genetics Guanine - analogs & derivatives Guanine - therapeutic use Hepatitis Hepatitis B Hepatitis B virus Hepatitis B virus - classification Hepatitis B virus - drug effects Hepatitis B virus - genetics Hepatitis B virus - isolation & purification hepatitis B virus/drug effects/genetics Hepatitis B, Chronic - drug therapy Hepatitis B, Chronic - virology Humans Lamivudine - therapeutic use Liver cirrhosis Liver diseases Male Medical sciences Middle Aged molecular Mutation Pharmacology. Drug treatments Phylogeny Retrospective Studies RNA-Directed DNA Polymerase - genetics Selection, Genetic Sequence Analysis, DNA - methods Studies Treatment Outcome Young Adult
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