Immunopathogenesis of vitiligo
Abstract Vitiligo is a common depigmenting disorder which may have devastating psychological and social consequences and is characterized by the presence of circumscribed white macules in the skin due to the destruction of melanocytes in the epidermis. Various hypotheses have been proposed to explai...
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| Veröffentlicht in: | Autoimmunity reviews 2011-10, Vol.10 (12), p.762-765 |
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| container_title | Autoimmunity reviews |
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| creator | Sandoval-Cruz, Manuel García-Carrasco, Mario Sánchez-Porras, Renán Mendoza-Pinto, Claudia Jiménez-Hernández, Mario Munguía-Realpozo, Pamela Ruiz-Argüelles, Alejandro |
| description | Abstract Vitiligo is a common depigmenting disorder which may have devastating psychological and social consequences and is characterized by the presence of circumscribed white macules in the skin due to the destruction of melanocytes in the epidermis. Various hypotheses have been proposed to explain the pathomechanisms involved in this disease, and studies have shown the participation of autoimmune processes in the pathogenesis of vitiligo. Cellular and humoral immunities have been implicated in the development of vitiligo and their role continues to be investigated. Peripheral blood and skin biopsies of patients with vitiligo show that T-cells, mononuclear cells, various pro-inflammatory cytokines, and auto-antibodies can damage melanocytes. Further research is required to determine whether autoimmunity is the main mechanism of vitiligo or only a consequence. |
| doi_str_mv | 10.1016/j.autrev.2011.02.004 |
| format | Article |
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Various hypotheses have been proposed to explain the pathomechanisms involved in this disease, and studies have shown the participation of autoimmune processes in the pathogenesis of vitiligo. Cellular and humoral immunities have been implicated in the development of vitiligo and their role continues to be investigated. Peripheral blood and skin biopsies of patients with vitiligo show that T-cells, mononuclear cells, various pro-inflammatory cytokines, and auto-antibodies can damage melanocytes. Further research is required to determine whether autoimmunity is the main mechanism of vitiligo or only a consequence.</description><identifier>ISSN: 1568-9972</identifier><identifier>EISSN: 1568-9972</identifier><identifier>EISSN: 1873-0183</identifier><identifier>DOI: 10.1016/j.autrev.2011.02.004</identifier><identifier>PMID: 21334464</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Allergy and Immunology ; Autoimmune Diseases - complications ; Autoimmunity ; Humans ; Melanocyte ; Melanocytes - immunology ; Melanocytes - pathology ; Pathogenesis ; Vitiligo ; Vitiligo - immunology ; Vitiligo - pathology</subject><ispartof>Autoimmunity reviews, 2011-10, Vol.10 (12), p.762-765</ispartof><rights>2011</rights><rights>Copyright © 2011. 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Various hypotheses have been proposed to explain the pathomechanisms involved in this disease, and studies have shown the participation of autoimmune processes in the pathogenesis of vitiligo. Cellular and humoral immunities have been implicated in the development of vitiligo and their role continues to be investigated. Peripheral blood and skin biopsies of patients with vitiligo show that T-cells, mononuclear cells, various pro-inflammatory cytokines, and auto-antibodies can damage melanocytes. Further research is required to determine whether autoimmunity is the main mechanism of vitiligo or only a consequence.</description><subject>Allergy and Immunology</subject><subject>Autoimmune Diseases - complications</subject><subject>Autoimmunity</subject><subject>Humans</subject><subject>Melanocyte</subject><subject>Melanocytes - immunology</subject><subject>Melanocytes - pathology</subject><subject>Pathogenesis</subject><subject>Vitiligo</subject><subject>Vitiligo - immunology</subject><subject>Vitiligo - pathology</subject><issn>1568-9972</issn><issn>1568-9972</issn><issn>1873-0183</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkT9PwzAQxS0EoqXwDVDVjanh7LhuvCAhxJ9KlRiA2Uqdc3FI4mInlfrtcZWCEAvL-Yb37p1_R8glhYQCFddlknetx23CgNIEWALAj8iQzkQ2lXLOjn_1A3IWQgnRJpk8JQNG05RzwYdkvKjrrnGbvH13a2ww2DBxZrK1ra3s2p2TE5NXAS8O74i8Pdy_3j1Nl8-Pi7vb5VRznrXTggm2AsMhk8hTUWijBTfazI0UuUHBDMoZL1g6l7EWQlBKNaa6mJuc4ypLR-Sqn7vx7rPD0KraBo1VlTfouqAkxBzI4tojwnul9i4Ej0ZtvK1zv1MU1B6MKlUPRu3BKGAqgom28SGgW9VY_Ji-SUTBTS_A-M2tRa-CtthoLKxH3arC2f8S_g7QlW2szqsP3GEoXeebiFBRFaJBveyPs78NpQCQgky_AEJoipw</recordid><startdate>20111001</startdate><enddate>20111001</enddate><creator>Sandoval-Cruz, Manuel</creator><creator>García-Carrasco, Mario</creator><creator>Sánchez-Porras, Renán</creator><creator>Mendoza-Pinto, Claudia</creator><creator>Jiménez-Hernández, Mario</creator><creator>Munguía-Realpozo, Pamela</creator><creator>Ruiz-Argüelles, Alejandro</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20111001</creationdate><title>Immunopathogenesis of vitiligo</title><author>Sandoval-Cruz, Manuel ; García-Carrasco, Mario ; Sánchez-Porras, Renán ; Mendoza-Pinto, Claudia ; Jiménez-Hernández, Mario ; Munguía-Realpozo, Pamela ; Ruiz-Argüelles, Alejandro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-d262b0f4089e436dcfc64fcf7f96afe62fe954d23794d2d66111ce3cd7fa4eb83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Allergy and Immunology</topic><topic>Autoimmune Diseases - complications</topic><topic>Autoimmunity</topic><topic>Humans</topic><topic>Melanocyte</topic><topic>Melanocytes - immunology</topic><topic>Melanocytes - pathology</topic><topic>Pathogenesis</topic><topic>Vitiligo</topic><topic>Vitiligo - immunology</topic><topic>Vitiligo - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sandoval-Cruz, Manuel</creatorcontrib><creatorcontrib>García-Carrasco, Mario</creatorcontrib><creatorcontrib>Sánchez-Porras, Renán</creatorcontrib><creatorcontrib>Mendoza-Pinto, Claudia</creatorcontrib><creatorcontrib>Jiménez-Hernández, Mario</creatorcontrib><creatorcontrib>Munguía-Realpozo, Pamela</creatorcontrib><creatorcontrib>Ruiz-Argüelles, Alejandro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Autoimmunity reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sandoval-Cruz, Manuel</au><au>García-Carrasco, Mario</au><au>Sánchez-Porras, Renán</au><au>Mendoza-Pinto, Claudia</au><au>Jiménez-Hernández, Mario</au><au>Munguía-Realpozo, Pamela</au><au>Ruiz-Argüelles, Alejandro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunopathogenesis of vitiligo</atitle><jtitle>Autoimmunity reviews</jtitle><addtitle>Autoimmun Rev</addtitle><date>2011-10-01</date><risdate>2011</risdate><volume>10</volume><issue>12</issue><spage>762</spage><epage>765</epage><pages>762-765</pages><issn>1568-9972</issn><eissn>1568-9972</eissn><eissn>1873-0183</eissn><abstract>Abstract Vitiligo is a common depigmenting disorder which may have devastating psychological and social consequences and is characterized by the presence of circumscribed white macules in the skin due to the destruction of melanocytes in the epidermis. 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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Allergy and Immunology Autoimmune Diseases - complications Autoimmunity Humans Melanocyte Melanocytes - immunology Melanocytes - pathology Pathogenesis Vitiligo Vitiligo - immunology Vitiligo - pathology |
| title | Immunopathogenesis of vitiligo |
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