Knockdown of PKR expression by RNAi reduces pulmonary metastatic potential of B16-F10 melanoma cells in mice: Possible role of NF-κB

Abstract It was suggested that PKR may act as a tumor suppressor. However, the results are still controversial. Here, we investigate the effect of PKR-specific short hairpin RNA (shRNA) expressing plasmids on pulmonary metastatic potential of B16-F10 melanoma cells in mice. Levels of both PKR mRNA a...

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Veröffentlicht in:	Cancer letters 2007-12, Vol.258 (1), p.118-125
Hauptverfasser:	Delgado André, Nayara, De Lucca, Fernando L
Format:	Artikel
Sprache:	eng
Schlagworte:	B16 Melanoma Cancer Hematology, Oncology and Palliative Medicine Metastasis NF-κB PKR RNA interference
Online-Zugang:	Volltext
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