Dexamethasone treatment of tumor necrosis factor-alpha challenged organ of Corti explants activates nuclear factor kappa B signaling that induces changes in gene expression that favor hair cell survival

Abstract The objective was to determine the role of nuclear factor kappa B (NFκB) in dexamethasone base (DXMb) protection of auditory hair cells from tumor necrosis factor-alpha (TNFα)-induced loss on gene expression and cell signaling levels. Organ of Corti (OC) explants from 3-day-old rats were cu...

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Veröffentlicht in:	Neuroscience 2011-08, Vol.188, p.157-167
Hauptverfasser:	Dinh, C.T, Bas, E, Chan, S.S, Dinh, J.N, Vu, L, Van De Water, T.R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacology Apoptosis - drug effects apoptosis-related genes auditory hair cells Biological and medical sciences Cell Survival - drug effects Dexamethasone - pharmacology Ear and associated structures. Auditory pathways and centers. Hearing. Vocal organ. Phonation. Sound production. Echolocation Enzyme-Linked Immunosorbent Assay Fluorescent Antibody Technique Fundamental and applied biological sciences. Psychology Gene Expression - drug effects Hair Cells, Auditory - drug effects Hair Cells, Auditory - metabolism Hair Cells, Auditory - pathology inflammation-related cytokine intracellular signaling Neurology NF-kappa B - metabolism Organ Culture Techniques Organ of Corti - drug effects Organ of Corti - metabolism Organ of Corti - pathology otoprotection Rats Rats, Sprague-Dawley Reverse Transcriptase Polymerase Chain Reaction Signal Transduction - drug effects synthetic corticosteroid Tumor Necrosis Factor-alpha - toxicity Vertebrates: nervous system and sense organs
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