1H-magnetic resonance spectroscopy indicates damage to cerebral white matter in the subacute phase after CO poisoning
ObjectiveThe authors examined whether 1H-magnetic resonance spectroscopy (MRS) can identify damage to the centrum semiovale in the subacute phase after CO exposure.MethodsSubjects comprised 29 adult patients who were treated with hyperbaric oxygenation within a range of 4–95 h (mean 18.7 h) after CO...
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| Veröffentlicht in: | Journal of neurology, neurosurgery and psychiatry neurosurgery and psychiatry, 2011-08, Vol.82 (8), p.869-875 |
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| creator | Beppu, Takaaki Nishimoto, Hideaki Fujiwara, Shunrou Kudo, Kaoru Sanjo, Katsumi Narumi, Shinsuke Oikawa, Hirotaka Onodera, Makoto Ogasawara, Kuniaki Sasaki, Makoto |
| description | ObjectiveThe authors examined whether 1H-magnetic resonance spectroscopy (MRS) can identify damage to the centrum semiovale in the subacute phase after CO exposure.MethodsSubjects comprised 29 adult patients who were treated with hyperbaric oxygenation within a range of 4–95 h (mean 18.7 h) after CO exposure. Subjects were classified into three groups according to clinical behaviours: Group A, patients with transit acute symptoms only; Group P, patients with persistent neurological symptoms; and Group D, patients with ‘delayed neuropsychiatric sequelae’ occurring after a lucid interval. MRS of bilateral centrum semiovale was performed 2 weeks after CO inhalation for all patients and 13 healthy volunteers. The mean ratios of choline-containing compounds/creatine (meanCho/Cr) and N-acetylaspartate/Cr (meanNAA/Cr) for bilateral centrum semiovale were calculated and compared between the three CO groups and controls. Myelin basic protein (MBP) concentration in cerebrospinal fluid was examined at 2 weeks to evaluate the degree of demyelination in patients.ResultsMBP concentration was abnormal for almost all patients in Groups P and D, but was not abnormal for any Group A patients. The meanCho/Cr ratios were significantly higher in Groups P and D than in Group A. No significant difference in meanNAA/Cr ratio was seen between the three pathological groups and controls. A significant correlation was identified between MBP and meanCho/Cr ratio.ConclusionsThese results suggest that the Cho/Cr ratio in the subacute phase after CO intoxication represents early demyelination in the centrum semiovale, and can predict chronic neurological symptoms. |
| doi_str_mv | 10.1136/jnnp.2010.222422 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_904479299</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4023889811</sourcerecordid><originalsourceid>FETCH-LOGICAL-b3076-914e10b35dcded546309b942301d518781a3fe2c4a608bb6514685d7ede921e33</originalsourceid><addsrcrecordid>eNqFkUtv1DAUhS0EokNhzwpZQogFSvErjr1EQ9tBquiG185ynJuOh7xqO6L99zjKUCQ2eGP53u_chw9CLyk5o5TL94dhmM4YyU_GmGDsEdpQIVXBOfnxGG0IYazgpCQn6FmMB7IcpZ-iE0YXWskNmumu6O3NAMk7HCCOgx0c4DiBS2GMbpzusR8a72yCiBubWcBpxA4C1MF2-NfeJ8C9TQlCJnHaZ_VcWzfn8LS3EbBtl9z2Gk-jzw38cPMcPWltF-HF8T5FXy_Ov2x3xdX15afth6ui5qSShaYCKKl52bgGmlJITnStBeOENiVVlaKWt8CcsJKoupblsnzZVNCAZhQ4P0Vv17pTGG9niMn0PjroOjvAOEejiRCVZlpn8vU_5GGcw5CHMzT3YUIyojJFVsrlv4kBWjMF39twbygxiyNmccQsjpjVkSx5dSw81z00D4I_FmTgzRGw0dmuDdkAH_9ygivF-LJLsXI-Jrh7yNvw08iKV6X5_G1rvn8sS3m5uzBV5t-tfN0f_j_mb6YssDk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1781246208</pqid></control><display><type>article</type><title>1H-magnetic resonance spectroscopy indicates damage to cerebral white matter in the subacute phase after CO poisoning</title><source>MEDLINE</source><source>BMJ Journals - NESLi2</source><creator>Beppu, Takaaki ; Nishimoto, Hideaki ; Fujiwara, Shunrou ; Kudo, Kaoru ; Sanjo, Katsumi ; Narumi, Shinsuke ; Oikawa, Hirotaka ; Onodera, Makoto ; Ogasawara, Kuniaki ; Sasaki, Makoto</creator><creatorcontrib>Beppu, Takaaki ; Nishimoto, Hideaki ; Fujiwara, Shunrou ; Kudo, Kaoru ; Sanjo, Katsumi ; Narumi, Shinsuke ; Oikawa, Hirotaka ; Onodera, Makoto ; Ogasawara, Kuniaki ; Sasaki, Makoto</creatorcontrib><description>ObjectiveThe authors examined whether 1H-magnetic resonance spectroscopy (MRS) can identify damage to the centrum semiovale in the subacute phase after CO exposure.MethodsSubjects comprised 29 adult patients who were treated with hyperbaric oxygenation within a range of 4–95 h (mean 18.7 h) after CO exposure. Subjects were classified into three groups according to clinical behaviours: Group A, patients with transit acute symptoms only; Group P, patients with persistent neurological symptoms; and Group D, patients with ‘delayed neuropsychiatric sequelae’ occurring after a lucid interval. MRS of bilateral centrum semiovale was performed 2 weeks after CO inhalation for all patients and 13 healthy volunteers. The mean ratios of choline-containing compounds/creatine (meanCho/Cr) and N-acetylaspartate/Cr (meanNAA/Cr) for bilateral centrum semiovale were calculated and compared between the three CO groups and controls. Myelin basic protein (MBP) concentration in cerebrospinal fluid was examined at 2 weeks to evaluate the degree of demyelination in patients.ResultsMBP concentration was abnormal for almost all patients in Groups P and D, but was not abnormal for any Group A patients. The meanCho/Cr ratios were significantly higher in Groups P and D than in Group A. No significant difference in meanNAA/Cr ratio was seen between the three pathological groups and controls. A significant correlation was identified between MBP and meanCho/Cr ratio.ConclusionsThese results suggest that the Cho/Cr ratio in the subacute phase after CO intoxication represents early demyelination in the centrum semiovale, and can predict chronic neurological symptoms.</description><identifier>ISSN: 0022-3050</identifier><identifier>EISSN: 1468-330X</identifier><identifier>DOI: 10.1136/jnnp.2010.222422</identifier><identifier>PMID: 21242286</identifier><identifier>CODEN: JNNPAU</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd</publisher><subject>1H-magnetic resonance spectroscopy ; Biological and medical sciences ; Brain - metabolism ; Brain - physiopathology ; Brain Diseases, Metabolic - diagnosis ; Brain Diseases, Metabolic - etiology ; Brain Diseases, Metabolic - metabolism ; Carbon monoxide poisoning ; Carbon Monoxide Poisoning - complications ; Carbon Monoxide Poisoning - physiopathology ; Carbon Monoxide Poisoning - therapy ; cerebral metabolism ; Choline - metabolism ; Contractors ; Creatine - metabolism ; delayed neuropathy ; Demyelinating Diseases - diagnosis ; Demyelinating Diseases - etiology ; Demyelinating Diseases - metabolism ; demyelination ; Female ; Follow-Up Studies ; Hospitals ; Humans ; Hyperbaric Oxygenation ; image analysis ; Investigative techniques, diagnostic techniques (general aspects) ; Magnetic Resonance Spectroscopy ; Male ; Medical sciences ; Metabolism ; Metabolites ; Middle Aged ; MRS ; myelin basic protein ; Myelin Basic Protein - cerebrospinal fluid ; Nerve Fibers, Myelinated - metabolism ; Nervous system ; Neurology ; neurotoxicology ; Poisoning ; Protons ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Spectrum analysis ; Studies ; Time Factors</subject><ispartof>Journal of neurology, neurosurgery and psychiatry, 2011-08, Vol.82 (8), p.869-875</ispartof><rights>2011, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright: 2011 (c) 2011, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b3076-914e10b35dcded546309b942301d518781a3fe2c4a608bb6514685d7ede921e33</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://jnnp.bmj.com/content/82/8/869.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttps://jnnp.bmj.com/content/82/8/869.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,314,780,784,3196,23571,27924,27925,77600,77631</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24388233$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21242286$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Beppu, Takaaki</creatorcontrib><creatorcontrib>Nishimoto, Hideaki</creatorcontrib><creatorcontrib>Fujiwara, Shunrou</creatorcontrib><creatorcontrib>Kudo, Kaoru</creatorcontrib><creatorcontrib>Sanjo, Katsumi</creatorcontrib><creatorcontrib>Narumi, Shinsuke</creatorcontrib><creatorcontrib>Oikawa, Hirotaka</creatorcontrib><creatorcontrib>Onodera, Makoto</creatorcontrib><creatorcontrib>Ogasawara, Kuniaki</creatorcontrib><creatorcontrib>Sasaki, Makoto</creatorcontrib><title>1H-magnetic resonance spectroscopy indicates damage to cerebral white matter in the subacute phase after CO poisoning</title><title>Journal of neurology, neurosurgery and psychiatry</title><addtitle>J Neurol Neurosurg Psychiatry</addtitle><description>ObjectiveThe authors examined whether 1H-magnetic resonance spectroscopy (MRS) can identify damage to the centrum semiovale in the subacute phase after CO exposure.MethodsSubjects comprised 29 adult patients who were treated with hyperbaric oxygenation within a range of 4–95 h (mean 18.7 h) after CO exposure. Subjects were classified into three groups according to clinical behaviours: Group A, patients with transit acute symptoms only; Group P, patients with persistent neurological symptoms; and Group D, patients with ‘delayed neuropsychiatric sequelae’ occurring after a lucid interval. MRS of bilateral centrum semiovale was performed 2 weeks after CO inhalation for all patients and 13 healthy volunteers. The mean ratios of choline-containing compounds/creatine (meanCho/Cr) and N-acetylaspartate/Cr (meanNAA/Cr) for bilateral centrum semiovale were calculated and compared between the three CO groups and controls. Myelin basic protein (MBP) concentration in cerebrospinal fluid was examined at 2 weeks to evaluate the degree of demyelination in patients.ResultsMBP concentration was abnormal for almost all patients in Groups P and D, but was not abnormal for any Group A patients. The meanCho/Cr ratios were significantly higher in Groups P and D than in Group A. No significant difference in meanNAA/Cr ratio was seen between the three pathological groups and controls. A significant correlation was identified between MBP and meanCho/Cr ratio.ConclusionsThese results suggest that the Cho/Cr ratio in the subacute phase after CO intoxication represents early demyelination in the centrum semiovale, and can predict chronic neurological symptoms.</description><subject>1H-magnetic resonance spectroscopy</subject><subject>Biological and medical sciences</subject><subject>Brain - metabolism</subject><subject>Brain - physiopathology</subject><subject>Brain Diseases, Metabolic - diagnosis</subject><subject>Brain Diseases, Metabolic - etiology</subject><subject>Brain Diseases, Metabolic - metabolism</subject><subject>Carbon monoxide poisoning</subject><subject>Carbon Monoxide Poisoning - complications</subject><subject>Carbon Monoxide Poisoning - physiopathology</subject><subject>Carbon Monoxide Poisoning - therapy</subject><subject>cerebral metabolism</subject><subject>Choline - metabolism</subject><subject>Contractors</subject><subject>Creatine - metabolism</subject><subject>delayed neuropathy</subject><subject>Demyelinating Diseases - diagnosis</subject><subject>Demyelinating Diseases - etiology</subject><subject>Demyelinating Diseases - metabolism</subject><subject>demyelination</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hyperbaric Oxygenation</subject><subject>image analysis</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Middle Aged</subject><subject>MRS</subject><subject>myelin basic protein</subject><subject>Myelin Basic Protein - cerebrospinal fluid</subject><subject>Nerve Fibers, Myelinated - metabolism</subject><subject>Nervous system</subject><subject>Neurology</subject><subject>neurotoxicology</subject><subject>Poisoning</subject><subject>Protons</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>Spectrum analysis</subject><subject>Studies</subject><subject>Time Factors</subject><issn>0022-3050</issn><issn>1468-330X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkUtv1DAUhS0EokNhzwpZQogFSvErjr1EQ9tBquiG185ynJuOh7xqO6L99zjKUCQ2eGP53u_chw9CLyk5o5TL94dhmM4YyU_GmGDsEdpQIVXBOfnxGG0IYazgpCQn6FmMB7IcpZ-iE0YXWskNmumu6O3NAMk7HCCOgx0c4DiBS2GMbpzusR8a72yCiBubWcBpxA4C1MF2-NfeJ8C9TQlCJnHaZ_VcWzfn8LS3EbBtl9z2Gk-jzw38cPMcPWltF-HF8T5FXy_Ov2x3xdX15afth6ui5qSShaYCKKl52bgGmlJITnStBeOENiVVlaKWt8CcsJKoupblsnzZVNCAZhQ4P0Vv17pTGG9niMn0PjroOjvAOEejiRCVZlpn8vU_5GGcw5CHMzT3YUIyojJFVsrlv4kBWjMF39twbygxiyNmccQsjpjVkSx5dSw81z00D4I_FmTgzRGw0dmuDdkAH_9ygivF-LJLsXI-Jrh7yNvw08iKV6X5_G1rvn8sS3m5uzBV5t-tfN0f_j_mb6YssDk</recordid><startdate>201108</startdate><enddate>201108</enddate><creator>Beppu, Takaaki</creator><creator>Nishimoto, Hideaki</creator><creator>Fujiwara, Shunrou</creator><creator>Kudo, Kaoru</creator><creator>Sanjo, Katsumi</creator><creator>Narumi, Shinsuke</creator><creator>Oikawa, Hirotaka</creator><creator>Onodera, Makoto</creator><creator>Ogasawara, Kuniaki</creator><creator>Sasaki, Makoto</creator><general>BMJ Publishing Group Ltd</general><general>BMJ Publishing Group</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7TK</scope></search><sort><creationdate>201108</creationdate><title>1H-magnetic resonance spectroscopy indicates damage to cerebral white matter in the subacute phase after CO poisoning</title><author>Beppu, Takaaki ; Nishimoto, Hideaki ; Fujiwara, Shunrou ; Kudo, Kaoru ; Sanjo, Katsumi ; Narumi, Shinsuke ; Oikawa, Hirotaka ; Onodera, Makoto ; Ogasawara, Kuniaki ; Sasaki, Makoto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b3076-914e10b35dcded546309b942301d518781a3fe2c4a608bb6514685d7ede921e33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>1H-magnetic resonance spectroscopy</topic><topic>Biological and medical sciences</topic><topic>Brain - metabolism</topic><topic>Brain - physiopathology</topic><topic>Brain Diseases, Metabolic - diagnosis</topic><topic>Brain Diseases, Metabolic - etiology</topic><topic>Brain Diseases, Metabolic - metabolism</topic><topic>Carbon monoxide poisoning</topic><topic>Carbon Monoxide Poisoning - complications</topic><topic>Carbon Monoxide Poisoning - physiopathology</topic><topic>Carbon Monoxide Poisoning - therapy</topic><topic>cerebral metabolism</topic><topic>Choline - metabolism</topic><topic>Contractors</topic><topic>Creatine - metabolism</topic><topic>delayed neuropathy</topic><topic>Demyelinating Diseases - diagnosis</topic><topic>Demyelinating Diseases - etiology</topic><topic>Demyelinating Diseases - metabolism</topic><topic>demyelination</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Hyperbaric Oxygenation</topic><topic>image analysis</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolism</topic><topic>Metabolites</topic><topic>Middle Aged</topic><topic>MRS</topic><topic>myelin basic protein</topic><topic>Myelin Basic Protein - cerebrospinal fluid</topic><topic>Nerve Fibers, Myelinated - metabolism</topic><topic>Nervous system</topic><topic>Neurology</topic><topic>neurotoxicology</topic><topic>Poisoning</topic><topic>Protons</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>Spectrum analysis</topic><topic>Studies</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Beppu, Takaaki</creatorcontrib><creatorcontrib>Nishimoto, Hideaki</creatorcontrib><creatorcontrib>Fujiwara, Shunrou</creatorcontrib><creatorcontrib>Kudo, Kaoru</creatorcontrib><creatorcontrib>Sanjo, Katsumi</creatorcontrib><creatorcontrib>Narumi, Shinsuke</creatorcontrib><creatorcontrib>Oikawa, Hirotaka</creatorcontrib><creatorcontrib>Onodera, Makoto</creatorcontrib><creatorcontrib>Ogasawara, Kuniaki</creatorcontrib><creatorcontrib>Sasaki, Makoto</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>Neurosciences Abstracts</collection><jtitle>Journal of neurology, neurosurgery and psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Beppu, Takaaki</au><au>Nishimoto, Hideaki</au><au>Fujiwara, Shunrou</au><au>Kudo, Kaoru</au><au>Sanjo, Katsumi</au><au>Narumi, Shinsuke</au><au>Oikawa, Hirotaka</au><au>Onodera, Makoto</au><au>Ogasawara, Kuniaki</au><au>Sasaki, Makoto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>1H-magnetic resonance spectroscopy indicates damage to cerebral white matter in the subacute phase after CO poisoning</atitle><jtitle>Journal of neurology, neurosurgery and psychiatry</jtitle><addtitle>J Neurol Neurosurg Psychiatry</addtitle><date>2011-08</date><risdate>2011</risdate><volume>82</volume><issue>8</issue><spage>869</spage><epage>875</epage><pages>869-875</pages><issn>0022-3050</issn><eissn>1468-330X</eissn><coden>JNNPAU</coden><abstract>ObjectiveThe authors examined whether 1H-magnetic resonance spectroscopy (MRS) can identify damage to the centrum semiovale in the subacute phase after CO exposure.MethodsSubjects comprised 29 adult patients who were treated with hyperbaric oxygenation within a range of 4–95 h (mean 18.7 h) after CO exposure. Subjects were classified into three groups according to clinical behaviours: Group A, patients with transit acute symptoms only; Group P, patients with persistent neurological symptoms; and Group D, patients with ‘delayed neuropsychiatric sequelae’ occurring after a lucid interval. MRS of bilateral centrum semiovale was performed 2 weeks after CO inhalation for all patients and 13 healthy volunteers. The mean ratios of choline-containing compounds/creatine (meanCho/Cr) and N-acetylaspartate/Cr (meanNAA/Cr) for bilateral centrum semiovale were calculated and compared between the three CO groups and controls. Myelin basic protein (MBP) concentration in cerebrospinal fluid was examined at 2 weeks to evaluate the degree of demyelination in patients.ResultsMBP concentration was abnormal for almost all patients in Groups P and D, but was not abnormal for any Group A patients. The meanCho/Cr ratios were significantly higher in Groups P and D than in Group A. No significant difference in meanNAA/Cr ratio was seen between the three pathological groups and controls. A significant correlation was identified between MBP and meanCho/Cr ratio.ConclusionsThese results suggest that the Cho/Cr ratio in the subacute phase after CO intoxication represents early demyelination in the centrum semiovale, and can predict chronic neurological symptoms.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd</pub><pmid>21242286</pmid><doi>10.1136/jnnp.2010.222422</doi><tpages>7</tpages></addata></record> |
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| ispartof | Journal of neurology, neurosurgery and psychiatry, 2011-08, Vol.82 (8), p.869-875 |
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| subjects | 1H-magnetic resonance spectroscopy Biological and medical sciences Brain - metabolism Brain - physiopathology Brain Diseases, Metabolic - diagnosis Brain Diseases, Metabolic - etiology Brain Diseases, Metabolic - metabolism Carbon monoxide poisoning Carbon Monoxide Poisoning - complications Carbon Monoxide Poisoning - physiopathology Carbon Monoxide Poisoning - therapy cerebral metabolism Choline - metabolism Contractors Creatine - metabolism delayed neuropathy Demyelinating Diseases - diagnosis Demyelinating Diseases - etiology Demyelinating Diseases - metabolism demyelination Female Follow-Up Studies Hospitals Humans Hyperbaric Oxygenation image analysis Investigative techniques, diagnostic techniques (general aspects) Magnetic Resonance Spectroscopy Male Medical sciences Metabolism Metabolites Middle Aged MRS myelin basic protein Myelin Basic Protein - cerebrospinal fluid Nerve Fibers, Myelinated - metabolism Nervous system Neurology neurotoxicology Poisoning Protons Radiodiagnosis. Nmr imagery. Nmr spectrometry Spectrum analysis Studies Time Factors |
| title | 1H-magnetic resonance spectroscopy indicates damage to cerebral white matter in the subacute phase after CO poisoning |
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