TLR9 in peritoneal B-1b cells is essential for production of protective self-reactive IgM to control Th17 cells and severe autoimmunity

The role of TLR9 in the development of the autoimmune disease systemic lupus erythematosus is controversial. In different mouse models of the disease, loss of TLR9 abolishes the generation of anti-nucleosome IgG autoantibodies but at the same time exacerbates lupus disease. However, the TLR9-depende...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of immunology (1950) 2011-09, Vol.187 (6), p.2953-2965
Hauptverfasser:	Stoehr, Alexander D, Schoen, Carolin T, Mertes, Maria M M, Eiglmeier, Susanne, Holecska, Vivien, Lorenz, Alexandra K, Schommartz, Tim, Schoen, Anna-Lena, Hess, Constanze, Winkler, André, Wardemann, Hedda, Ehlers, Marc
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Ascitic Fluid - cytology Ascitic Fluid - immunology Autoantibodies - blood Autoantibodies - immunology Autoimmunity - immunology B-Lymphocytes - immunology B-Lymphocytes - metabolism Cell Separation Disease Models, Animal Enzyme-Linked Immunosorbent Assay Flow Cytometry Fluorescent Antibody Technique Immunoglobulin M - blood Immunoglobulin M - immunology Lupus Erythematosus, Systemic - immunology Lupus Erythematosus, Systemic - metabolism Mice Mice, Inbred C57BL Mice, Knockout Reverse Transcriptase Polymerase Chain Reaction Signal Transduction - immunology Th1 Cells - immunology Th1 Cells - metabolism Th17 Cells - immunology Th17 Cells - metabolism Toll-Like Receptor 9 - immunology Toll-Like Receptor 9 - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!