Altered responses of MeCP2-deficient mouse brain stem to severe hypoxia

Rett syndrome (RTT) patients suffer from respiratory arrhythmias with frequent apneas causing intermittent hypoxia. In a RTT mouse model (methyl-CpG-binding protein 2-deficient mice; Mecp2(-/y)) we recently discovered an enhanced hippocampal susceptibility to hypoxia and hypoxia-induced spreading de...

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Veröffentlicht in:	Journal of neurophysiology 2011-06, Vol.105 (6), p.3067-3079
Hauptverfasser:	Kron, Miriam, Zimmermann, Jasper L, Dutschmann, Mathias, Funke, Frank, Müller, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacology Analysis of Variance Animals Animals, Newborn Brain Stem - pathology Brain Stem - physiopathology Cortical Spreading Depression - drug effects Cortical Spreading Depression - genetics Electric Stimulation Extracellular Fluid - metabolism Hypoxia - genetics Hypoxia - pathology In Vitro Techniques Male Methyl-CpG-Binding Protein 2 - deficiency Mice Mice, Knockout Neural Pathways - physiology Potassium - metabolism Reaction Time - drug effects Reaction Time - genetics Respiratory Center - drug effects Respiratory Center - physiology Serotonin Receptor Agonists - pharmacology Solitary Nucleus - physiopathology Time Factors Trigeminal Nucleus, Spinal - physiopathology
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