Pericardial Fat Is Associated With Atrial Fibrillation Severity and Ablation Outcome
Objectives The aim of this study was to characterize the relationship between pericardial fat and atrial fibrillation (AF). Background Obesity is an important risk factor for AF. Pericardial fat has been hypothesized to exert local pathogenic effects on nearby cardiac structures above and beyond tha...
Gespeichert in:
| Veröffentlicht in: | Journal of the American College of Cardiology 2011-04, Vol.57 (17), p.1745-1751 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1751 |
|---|---|
| container_issue | 17 |
| container_start_page | 1745 |
| container_title | Journal of the American College of Cardiology |
| container_volume | 57 |
| creator | Wong, Christopher X Abed, Hany S., MBBS, BPharm Molaee, Payman, MBBS Nelson, Adam J., BMedSc Brooks, Anthony G., PhD Sharma, Gautam, MD Leong, Darryl P., MBBS Lau, Dennis H., MBBS Middeldorp, Melissa E Roberts-Thomson, Kurt C., MBBS, PhD Wittert, Gary A., MD Abhayaratna, Walter P., MBBS, PhD Worthley, Stephen G., MBBS, PhD Sanders, Prashanthan, MBBS, PhD |
| description | Objectives The aim of this study was to characterize the relationship between pericardial fat and atrial fibrillation (AF). Background Obesity is an important risk factor for AF. Pericardial fat has been hypothesized to exert local pathogenic effects on nearby cardiac structures above and beyond that of systemic adiposity. Methods One hundred ten patients undergoing first-time AF ablation and 20 reference patients without AF underwent cardiac magnetic resonance imaging for the quantification of periatrial, periventricular, and total pericardial fat volumes using a previously validated technique. Together with body mass index and body surface area, these were examined in relation to the presence of AF, the severity of AF, left atrial volume, and long-term AF recurrence after ablation. Results Pericardial fat volumes were significantly associated with the presence of AF, AF chronicity, and AF symptom burden (all p values |
| doi_str_mv | 10.1016/j.jacc.2010.11.045 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_904478140</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0735109711005523</els_id><sourcerecordid>3556591871</sourcerecordid><originalsourceid>FETCH-LOGICAL-c470t-3f7232fdf4746e6f07a937e907b4c3fa9f1692dbc51ee7851cb1a5cbbe38034c3</originalsourceid><addsrcrecordid>eNqFksFq3DAQhkVpabZpX6CHYuihJ29mLMmyoRSW0DSBQAJJ6VHI8pjK9dqpJAf27Stntw3kkAqEYPT9Mxr9w9h7hDUClif9ujfWrgtYArgGIV-wFUpZ5VzW6iVbgeIyR6jVEXsTQg8AZYX1a3ZUoMS0YMVur8k7a3zrzJCdmZhdhGwTwmSdidRmP1z8mW2if7h1jXfDYKKbxuyG7pMw7jIzttmmOUSv5minLb1lrzozBHp3OI_Z97Ovt6fn-eXVt4vTzWVuhYKY804VvOjaTihRUtmBMjVXVINqhOWdqTss66JtrEQiVUm0DRppm4Z4BTwhx-zTPu-dn37PFKLeumApvXGkaQ66BiFUhQL-S1YlF0XaPJEfn5D9NPsxtaGxFBIEolyoYk9ZP4XgqdN33m2N32kEvZije72YoxdzNKJO5iTRh0PqudlS-0_y140EfN4DlD7t3pHXwToaLbXOk426ndzz-b88kdvBjcnd4RftKDz2oUOhQd8s47FMRyoNUhac_wG2XLMm</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1645041153</pqid></control><display><type>article</type><title>Pericardial Fat Is Associated With Atrial Fibrillation Severity and Ablation Outcome</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>ScienceDirect Journals (5 years ago - present)</source><source>Alma/SFX Local Collection</source><creator>Wong, Christopher X ; Abed, Hany S., MBBS, BPharm ; Molaee, Payman, MBBS ; Nelson, Adam J., BMedSc ; Brooks, Anthony G., PhD ; Sharma, Gautam, MD ; Leong, Darryl P., MBBS ; Lau, Dennis H., MBBS ; Middeldorp, Melissa E ; Roberts-Thomson, Kurt C., MBBS, PhD ; Wittert, Gary A., MD ; Abhayaratna, Walter P., MBBS, PhD ; Worthley, Stephen G., MBBS, PhD ; Sanders, Prashanthan, MBBS, PhD</creator><creatorcontrib>Wong, Christopher X ; Abed, Hany S., MBBS, BPharm ; Molaee, Payman, MBBS ; Nelson, Adam J., BMedSc ; Brooks, Anthony G., PhD ; Sharma, Gautam, MD ; Leong, Darryl P., MBBS ; Lau, Dennis H., MBBS ; Middeldorp, Melissa E ; Roberts-Thomson, Kurt C., MBBS, PhD ; Wittert, Gary A., MD ; Abhayaratna, Walter P., MBBS, PhD ; Worthley, Stephen G., MBBS, PhD ; Sanders, Prashanthan, MBBS, PhD</creatorcontrib><description>Objectives The aim of this study was to characterize the relationship between pericardial fat and atrial fibrillation (AF). Background Obesity is an important risk factor for AF. Pericardial fat has been hypothesized to exert local pathogenic effects on nearby cardiac structures above and beyond that of systemic adiposity. Methods One hundred ten patients undergoing first-time AF ablation and 20 reference patients without AF underwent cardiac magnetic resonance imaging for the quantification of periatrial, periventricular, and total pericardial fat volumes using a previously validated technique. Together with body mass index and body surface area, these were examined in relation to the presence of AF, the severity of AF, left atrial volume, and long-term AF recurrence after ablation. Results Pericardial fat volumes were significantly associated with the presence of AF, AF chronicity, and AF symptom burden (all p values <0.05). Pericardial fat depots were also predictive of long-term AF recurrence after ablation (p = 0.035). Finally, pericardial fat depots were also associated with left atrial volume (total pericardial fat: r = 0.46, p < 0.001). Importantly, these associations persisted after multivariate adjustment and additional adjustment for body weight. In contrast, however, systemic measures of adiposity, such as body mass index and body surface area, were not associated with these outcomes in multivariate-adjusted models. Conclusions Pericardial fat is associated with the presence of AF, the severity of AF, left atrial volumes, and poorer outcomes after AF ablation. These associations are both independent of and stronger than more systemic measures of adiposity. These findings are consistent with the hypothesis of a local pathogenic effect of pericardial fat on the arrhythmogenic substrate supporting AF.</description><identifier>ISSN: 0735-1097</identifier><identifier>EISSN: 1558-3597</identifier><identifier>DOI: 10.1016/j.jacc.2010.11.045</identifier><identifier>PMID: 21511110</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adipose Tissue - pathology ; Aged ; atrial fibrillation ; Atrial Fibrillation - diagnosis ; Atrial Fibrillation - surgery ; Body mass index ; Cardiac arrhythmia ; Cardiology ; Cardiovascular ; Cardiovascular disease ; Catheter Ablation - methods ; Colleges & universities ; Confidence intervals ; Diabetes ; Female ; Follow-Up Studies ; Heart ; Humans ; Hypertension ; Internal Medicine ; magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Male ; Middle Aged ; obesity ; pericardial fat ; Pericardium - pathology ; Risk factors ; Severity of Illness Index ; Sleep apnea ; Treatment Outcome</subject><ispartof>Journal of the American College of Cardiology, 2011-04, Vol.57 (17), p.1745-1751</ispartof><rights>American College of Cardiology Foundation</rights><rights>2011 American College of Cardiology Foundation</rights><rights>Copyright © 2011 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Apr 26, 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-3f7232fdf4746e6f07a937e907b4c3fa9f1692dbc51ee7851cb1a5cbbe38034c3</citedby><cites>FETCH-LOGICAL-c470t-3f7232fdf4746e6f07a937e907b4c3fa9f1692dbc51ee7851cb1a5cbbe38034c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jacc.2010.11.045$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21511110$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wong, Christopher X</creatorcontrib><creatorcontrib>Abed, Hany S., MBBS, BPharm</creatorcontrib><creatorcontrib>Molaee, Payman, MBBS</creatorcontrib><creatorcontrib>Nelson, Adam J., BMedSc</creatorcontrib><creatorcontrib>Brooks, Anthony G., PhD</creatorcontrib><creatorcontrib>Sharma, Gautam, MD</creatorcontrib><creatorcontrib>Leong, Darryl P., MBBS</creatorcontrib><creatorcontrib>Lau, Dennis H., MBBS</creatorcontrib><creatorcontrib>Middeldorp, Melissa E</creatorcontrib><creatorcontrib>Roberts-Thomson, Kurt C., MBBS, PhD</creatorcontrib><creatorcontrib>Wittert, Gary A., MD</creatorcontrib><creatorcontrib>Abhayaratna, Walter P., MBBS, PhD</creatorcontrib><creatorcontrib>Worthley, Stephen G., MBBS, PhD</creatorcontrib><creatorcontrib>Sanders, Prashanthan, MBBS, PhD</creatorcontrib><title>Pericardial Fat Is Associated With Atrial Fibrillation Severity and Ablation Outcome</title><title>Journal of the American College of Cardiology</title><addtitle>J Am Coll Cardiol</addtitle><description>Objectives The aim of this study was to characterize the relationship between pericardial fat and atrial fibrillation (AF). Background Obesity is an important risk factor for AF. Pericardial fat has been hypothesized to exert local pathogenic effects on nearby cardiac structures above and beyond that of systemic adiposity. Methods One hundred ten patients undergoing first-time AF ablation and 20 reference patients without AF underwent cardiac magnetic resonance imaging for the quantification of periatrial, periventricular, and total pericardial fat volumes using a previously validated technique. Together with body mass index and body surface area, these were examined in relation to the presence of AF, the severity of AF, left atrial volume, and long-term AF recurrence after ablation. Results Pericardial fat volumes were significantly associated with the presence of AF, AF chronicity, and AF symptom burden (all p values <0.05). Pericardial fat depots were also predictive of long-term AF recurrence after ablation (p = 0.035). Finally, pericardial fat depots were also associated with left atrial volume (total pericardial fat: r = 0.46, p < 0.001). Importantly, these associations persisted after multivariate adjustment and additional adjustment for body weight. In contrast, however, systemic measures of adiposity, such as body mass index and body surface area, were not associated with these outcomes in multivariate-adjusted models. Conclusions Pericardial fat is associated with the presence of AF, the severity of AF, left atrial volumes, and poorer outcomes after AF ablation. These associations are both independent of and stronger than more systemic measures of adiposity. These findings are consistent with the hypothesis of a local pathogenic effect of pericardial fat on the arrhythmogenic substrate supporting AF.</description><subject>Adipose Tissue - pathology</subject><subject>Aged</subject><subject>atrial fibrillation</subject><subject>Atrial Fibrillation - diagnosis</subject><subject>Atrial Fibrillation - surgery</subject><subject>Body mass index</subject><subject>Cardiac arrhythmia</subject><subject>Cardiology</subject><subject>Cardiovascular</subject><subject>Cardiovascular disease</subject><subject>Catheter Ablation - methods</subject><subject>Colleges & universities</subject><subject>Confidence intervals</subject><subject>Diabetes</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Heart</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Internal Medicine</subject><subject>magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Male</subject><subject>Middle Aged</subject><subject>obesity</subject><subject>pericardial fat</subject><subject>Pericardium - pathology</subject><subject>Risk factors</subject><subject>Severity of Illness Index</subject><subject>Sleep apnea</subject><subject>Treatment Outcome</subject><issn>0735-1097</issn><issn>1558-3597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFksFq3DAQhkVpabZpX6CHYuihJ29mLMmyoRSW0DSBQAJJ6VHI8pjK9dqpJAf27Stntw3kkAqEYPT9Mxr9w9h7hDUClif9ujfWrgtYArgGIV-wFUpZ5VzW6iVbgeIyR6jVEXsTQg8AZYX1a3ZUoMS0YMVur8k7a3zrzJCdmZhdhGwTwmSdidRmP1z8mW2if7h1jXfDYKKbxuyG7pMw7jIzttmmOUSv5minLb1lrzozBHp3OI_Z97Ovt6fn-eXVt4vTzWVuhYKY804VvOjaTihRUtmBMjVXVINqhOWdqTss66JtrEQiVUm0DRppm4Z4BTwhx-zTPu-dn37PFKLeumApvXGkaQ66BiFUhQL-S1YlF0XaPJEfn5D9NPsxtaGxFBIEolyoYk9ZP4XgqdN33m2N32kEvZije72YoxdzNKJO5iTRh0PqudlS-0_y140EfN4DlD7t3pHXwToaLbXOk426ndzz-b88kdvBjcnd4RftKDz2oUOhQd8s47FMRyoNUhac_wG2XLMm</recordid><startdate>20110426</startdate><enddate>20110426</enddate><creator>Wong, Christopher X</creator><creator>Abed, Hany S., MBBS, BPharm</creator><creator>Molaee, Payman, MBBS</creator><creator>Nelson, Adam J., BMedSc</creator><creator>Brooks, Anthony G., PhD</creator><creator>Sharma, Gautam, MD</creator><creator>Leong, Darryl P., MBBS</creator><creator>Lau, Dennis H., MBBS</creator><creator>Middeldorp, Melissa E</creator><creator>Roberts-Thomson, Kurt C., MBBS, PhD</creator><creator>Wittert, Gary A., MD</creator><creator>Abhayaratna, Walter P., MBBS, PhD</creator><creator>Worthley, Stephen G., MBBS, PhD</creator><creator>Sanders, Prashanthan, MBBS, PhD</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>7T2</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope></search><sort><creationdate>20110426</creationdate><title>Pericardial Fat Is Associated With Atrial Fibrillation Severity and Ablation Outcome</title><author>Wong, Christopher X ; Abed, Hany S., MBBS, BPharm ; Molaee, Payman, MBBS ; Nelson, Adam J., BMedSc ; Brooks, Anthony G., PhD ; Sharma, Gautam, MD ; Leong, Darryl P., MBBS ; Lau, Dennis H., MBBS ; Middeldorp, Melissa E ; Roberts-Thomson, Kurt C., MBBS, PhD ; Wittert, Gary A., MD ; Abhayaratna, Walter P., MBBS, PhD ; Worthley, Stephen G., MBBS, PhD ; Sanders, Prashanthan, MBBS, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-3f7232fdf4746e6f07a937e907b4c3fa9f1692dbc51ee7851cb1a5cbbe38034c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adipose Tissue - pathology</topic><topic>Aged</topic><topic>atrial fibrillation</topic><topic>Atrial Fibrillation - diagnosis</topic><topic>Atrial Fibrillation - surgery</topic><topic>Body mass index</topic><topic>Cardiac arrhythmia</topic><topic>Cardiology</topic><topic>Cardiovascular</topic><topic>Cardiovascular disease</topic><topic>Catheter Ablation - methods</topic><topic>Colleges & universities</topic><topic>Confidence intervals</topic><topic>Diabetes</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Heart</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Internal Medicine</topic><topic>magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Male</topic><topic>Middle Aged</topic><topic>obesity</topic><topic>pericardial fat</topic><topic>Pericardium - pathology</topic><topic>Risk factors</topic><topic>Severity of Illness Index</topic><topic>Sleep apnea</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wong, Christopher X</creatorcontrib><creatorcontrib>Abed, Hany S., MBBS, BPharm</creatorcontrib><creatorcontrib>Molaee, Payman, MBBS</creatorcontrib><creatorcontrib>Nelson, Adam J., BMedSc</creatorcontrib><creatorcontrib>Brooks, Anthony G., PhD</creatorcontrib><creatorcontrib>Sharma, Gautam, MD</creatorcontrib><creatorcontrib>Leong, Darryl P., MBBS</creatorcontrib><creatorcontrib>Lau, Dennis H., MBBS</creatorcontrib><creatorcontrib>Middeldorp, Melissa E</creatorcontrib><creatorcontrib>Roberts-Thomson, Kurt C., MBBS, PhD</creatorcontrib><creatorcontrib>Wittert, Gary A., MD</creatorcontrib><creatorcontrib>Abhayaratna, Walter P., MBBS, PhD</creatorcontrib><creatorcontrib>Worthley, Stephen G., MBBS, PhD</creatorcontrib><creatorcontrib>Sanders, Prashanthan, MBBS, PhD</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Journal of the American College of Cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wong, Christopher X</au><au>Abed, Hany S., MBBS, BPharm</au><au>Molaee, Payman, MBBS</au><au>Nelson, Adam J., BMedSc</au><au>Brooks, Anthony G., PhD</au><au>Sharma, Gautam, MD</au><au>Leong, Darryl P., MBBS</au><au>Lau, Dennis H., MBBS</au><au>Middeldorp, Melissa E</au><au>Roberts-Thomson, Kurt C., MBBS, PhD</au><au>Wittert, Gary A., MD</au><au>Abhayaratna, Walter P., MBBS, PhD</au><au>Worthley, Stephen G., MBBS, PhD</au><au>Sanders, Prashanthan, MBBS, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pericardial Fat Is Associated With Atrial Fibrillation Severity and Ablation Outcome</atitle><jtitle>Journal of the American College of Cardiology</jtitle><addtitle>J Am Coll Cardiol</addtitle><date>2011-04-26</date><risdate>2011</risdate><volume>57</volume><issue>17</issue><spage>1745</spage><epage>1751</epage><pages>1745-1751</pages><issn>0735-1097</issn><eissn>1558-3597</eissn><abstract>Objectives The aim of this study was to characterize the relationship between pericardial fat and atrial fibrillation (AF). Background Obesity is an important risk factor for AF. Pericardial fat has been hypothesized to exert local pathogenic effects on nearby cardiac structures above and beyond that of systemic adiposity. Methods One hundred ten patients undergoing first-time AF ablation and 20 reference patients without AF underwent cardiac magnetic resonance imaging for the quantification of periatrial, periventricular, and total pericardial fat volumes using a previously validated technique. Together with body mass index and body surface area, these were examined in relation to the presence of AF, the severity of AF, left atrial volume, and long-term AF recurrence after ablation. Results Pericardial fat volumes were significantly associated with the presence of AF, AF chronicity, and AF symptom burden (all p values <0.05). Pericardial fat depots were also predictive of long-term AF recurrence after ablation (p = 0.035). Finally, pericardial fat depots were also associated with left atrial volume (total pericardial fat: r = 0.46, p < 0.001). Importantly, these associations persisted after multivariate adjustment and additional adjustment for body weight. In contrast, however, systemic measures of adiposity, such as body mass index and body surface area, were not associated with these outcomes in multivariate-adjusted models. Conclusions Pericardial fat is associated with the presence of AF, the severity of AF, left atrial volumes, and poorer outcomes after AF ablation. These associations are both independent of and stronger than more systemic measures of adiposity. These findings are consistent with the hypothesis of a local pathogenic effect of pericardial fat on the arrhythmogenic substrate supporting AF.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>21511110</pmid><doi>10.1016/j.jacc.2010.11.045</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0735-1097 |
| ispartof | Journal of the American College of Cardiology, 2011-04, Vol.57 (17), p.1745-1751 |
| issn | 0735-1097 1558-3597 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_904478140 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ScienceDirect Journals (5 years ago - present); Alma/SFX Local Collection |
| subjects | Adipose Tissue - pathology Aged atrial fibrillation Atrial Fibrillation - diagnosis Atrial Fibrillation - surgery Body mass index Cardiac arrhythmia Cardiology Cardiovascular Cardiovascular disease Catheter Ablation - methods Colleges & universities Confidence intervals Diabetes Female Follow-Up Studies Heart Humans Hypertension Internal Medicine magnetic resonance imaging Magnetic Resonance Imaging - methods Male Middle Aged obesity pericardial fat Pericardium - pathology Risk factors Severity of Illness Index Sleep apnea Treatment Outcome |
| title | Pericardial Fat Is Associated With Atrial Fibrillation Severity and Ablation Outcome |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T18%3A07%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Pericardial%20Fat%20Is%20Associated%20With%20Atrial%20Fibrillation%20Severity%20and%20Ablation%20Outcome&rft.jtitle=Journal%20of%20the%20American%20College%20of%20Cardiology&rft.au=Wong,%20Christopher%20X&rft.date=2011-04-26&rft.volume=57&rft.issue=17&rft.spage=1745&rft.epage=1751&rft.pages=1745-1751&rft.issn=0735-1097&rft.eissn=1558-3597&rft_id=info:doi/10.1016/j.jacc.2010.11.045&rft_dat=%3Cproquest_cross%3E3556591871%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1645041153&rft_id=info:pmid/21511110&rft_els_id=1_s2_0_S0735109711005523&rfr_iscdi=true |