DRD2/ANKK1 TaqI A polymorphism affects corticostriatal activity in response to negative affective facial stimuli
► DRD2/ANKK1 TaqI A polymorphism affects corticostriatal activity. ► Higher signal intensity in the homozygous group than in the heterozygous group. ► The molecular heterosis may play an important role in these responses. DRD2/ANKK1 TaqI A polymorphism has been suggested to be involved in a reward-r...
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| Veröffentlicht in: | Behavioural brain research 2011-09, Vol.223 (1), p.36-41 |
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| container_title | Behavioural brain research |
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| creator | Lee, Byeong-Taek Lee, Hwa-Young Han, Changsu Pae, Chi-Un Tae, Woo Suk Lee, Min-Soo Joe, Sook-Haeng Jung, In-Kwa Ham, Byung-Joo |
| description | ► DRD2/ANKK1
TaqI A polymorphism affects corticostriatal activity. ► Higher signal intensity in the homozygous group than in the heterozygous group. ► The molecular heterosis may play an important role in these responses.
DRD2/ANKK1
TaqI A polymorphism has been suggested to be involved in a reward-related psychiatric disorders. However, the effect of Dopamine receptor D2 (DRD2) on emotional processing has not been investigated yet. We investigated the possible relationship between DRD2/ANKK1
TaqI A polymorphism and corticostriatal response to negative facial stimuli using functional magnetic resonance imaging. All participants were genotyped with regard to the DRD2/ANKK1
TaqI A polymorphism. Our results suggest an association between the DRD2/ANKK1
TaqI A polymorphism and activations in the putamen, the anterior cingulate cortex, and amygdala in response to negative facial stimuli. Furthermore, molecular heterosis at the
TaqI polymorphism of DRD2/ANKK1 may play an important role in affective regulation by corticostriatal pathway. |
| doi_str_mv | 10.1016/j.bbr.2011.04.007 |
| format | Article |
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TaqI A polymorphism affects corticostriatal activity. ► Higher signal intensity in the homozygous group than in the heterozygous group. ► The molecular heterosis may play an important role in these responses.
DRD2/ANKK1
TaqI A polymorphism has been suggested to be involved in a reward-related psychiatric disorders. However, the effect of Dopamine receptor D2 (DRD2) on emotional processing has not been investigated yet. We investigated the possible relationship between DRD2/ANKK1
TaqI A polymorphism and corticostriatal response to negative facial stimuli using functional magnetic resonance imaging. All participants were genotyped with regard to the DRD2/ANKK1
TaqI A polymorphism. Our results suggest an association between the DRD2/ANKK1
TaqI A polymorphism and activations in the putamen, the anterior cingulate cortex, and amygdala in response to negative facial stimuli. Furthermore, molecular heterosis at the
TaqI polymorphism of DRD2/ANKK1 may play an important role in affective regulation by corticostriatal pathway.</description><identifier>ISSN: 0166-4328</identifier><identifier>EISSN: 1872-7549</identifier><identifier>DOI: 10.1016/j.bbr.2011.04.007</identifier><identifier>PMID: 21510979</identifier><identifier>CODEN: BBREDI</identifier><language>eng</language><publisher>Shannon: Elsevier B.V</publisher><subject>Adult ; Alleles ; Behavioral psychophysiology ; Biological and medical sciences ; Brain Mapping - methods ; Cerebral Cortex - physiology ; Corpus Striatum - physiology ; Dopamine receptor D2 ; Emotions - physiology ; Facial Expression ; Female ; fMRI ; Fundamental and applied biological sciences. Psychology ; Genotype ; Humans ; Magnetic Resonance Imaging - methods ; Neural Pathways - physiology ; Photic Stimulation - methods ; Polymorphism ; Polymorphism, Restriction Fragment Length ; Protein-Serine-Threonine Kinases - genetics ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Receptors, Dopamine D2 - genetics ; Striatum</subject><ispartof>Behavioural brain research, 2011-09, Vol.223 (1), p.36-41</ispartof><rights>2011 Elsevier B.V.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2011 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-cb9a7c8991ee22ef8e22dcec10fea46ba5c3de69ec6c5f3ca0a9398e3db085273</citedby><cites>FETCH-LOGICAL-c414t-cb9a7c8991ee22ef8e22dcec10fea46ba5c3de69ec6c5f3ca0a9398e3db085273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0166432811002944$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24281983$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21510979$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lee, Byeong-Taek</creatorcontrib><creatorcontrib>Lee, Hwa-Young</creatorcontrib><creatorcontrib>Han, Changsu</creatorcontrib><creatorcontrib>Pae, Chi-Un</creatorcontrib><creatorcontrib>Tae, Woo Suk</creatorcontrib><creatorcontrib>Lee, Min-Soo</creatorcontrib><creatorcontrib>Joe, Sook-Haeng</creatorcontrib><creatorcontrib>Jung, In-Kwa</creatorcontrib><creatorcontrib>Ham, Byung-Joo</creatorcontrib><title>DRD2/ANKK1 TaqI A polymorphism affects corticostriatal activity in response to negative affective facial stimuli</title><title>Behavioural brain research</title><addtitle>Behav Brain Res</addtitle><description>► DRD2/ANKK1
TaqI A polymorphism affects corticostriatal activity. ► Higher signal intensity in the homozygous group than in the heterozygous group. ► The molecular heterosis may play an important role in these responses.
DRD2/ANKK1
TaqI A polymorphism has been suggested to be involved in a reward-related psychiatric disorders. However, the effect of Dopamine receptor D2 (DRD2) on emotional processing has not been investigated yet. We investigated the possible relationship between DRD2/ANKK1
TaqI A polymorphism and corticostriatal response to negative facial stimuli using functional magnetic resonance imaging. All participants were genotyped with regard to the DRD2/ANKK1
TaqI A polymorphism. Our results suggest an association between the DRD2/ANKK1
TaqI A polymorphism and activations in the putamen, the anterior cingulate cortex, and amygdala in response to negative facial stimuli. Furthermore, molecular heterosis at the
TaqI polymorphism of DRD2/ANKK1 may play an important role in affective regulation by corticostriatal pathway.</description><subject>Adult</subject><subject>Alleles</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Brain Mapping - methods</subject><subject>Cerebral Cortex - physiology</subject><subject>Corpus Striatum - physiology</subject><subject>Dopamine receptor D2</subject><subject>Emotions - physiology</subject><subject>Facial Expression</subject><subject>Female</subject><subject>fMRI</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genotype</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Neural Pathways - physiology</subject><subject>Photic Stimulation - methods</subject><subject>Polymorphism</subject><subject>Polymorphism, Restriction Fragment Length</subject><subject>Protein-Serine-Threonine Kinases - genetics</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Receptors, Dopamine D2 - genetics</subject><subject>Striatum</subject><issn>0166-4328</issn><issn>1872-7549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFu1DAQhi0EotuFB-CCfEGcktqOk9jitGopVK1aCZWz5Uwm4FUSp7a30r49Xu0CN5AseyR__2g0HyHvOCs5483Ftuy6UArGeclkyVj7gqy4akXR1lK_JKvMNIWshDoj5zFuGWOS1fw1ORO85ky3ekWWq29X4mJzf3vL6aN9uqEbuvhxP_mw_HRxonYYEFKk4ENy4GMKziY7UgvJPbu0p26mAePi54g0eTrjD5t_8BQ8VIMFlxMxuWk3ujfk1WDHiG9P75p8v_78ePm1uHv4cnO5uStAcpkK6LRtQWnNEYXAQeW7BwTOBrSy6WwNVY-NRmigHiqwzOpKK6z6jqlatNWafDz2XYJ_2mFMZnIRcBztjH4XjWZStoq19X9J1fJKicNZE34kIfgYAw5mCW6yYW84MwcjZmuyEXMwYpg02UjOvD9133UT9n8SvxVk4MMJsBHsOAQ7g4t_OSkU16rK3Kcjh3lrzw6DieBwBuxdyJs2vXf_GOMX6GqqGg</recordid><startdate>20110930</startdate><enddate>20110930</enddate><creator>Lee, Byeong-Taek</creator><creator>Lee, Hwa-Young</creator><creator>Han, Changsu</creator><creator>Pae, Chi-Un</creator><creator>Tae, Woo Suk</creator><creator>Lee, Min-Soo</creator><creator>Joe, Sook-Haeng</creator><creator>Jung, In-Kwa</creator><creator>Ham, Byung-Joo</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QG</scope><scope>7TK</scope></search><sort><creationdate>20110930</creationdate><title>DRD2/ANKK1 TaqI A polymorphism affects corticostriatal activity in response to negative affective facial stimuli</title><author>Lee, Byeong-Taek ; Lee, Hwa-Young ; Han, Changsu ; Pae, Chi-Un ; Tae, Woo Suk ; Lee, Min-Soo ; Joe, Sook-Haeng ; Jung, In-Kwa ; Ham, Byung-Joo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c414t-cb9a7c8991ee22ef8e22dcec10fea46ba5c3de69ec6c5f3ca0a9398e3db085273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Alleles</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Brain Mapping - methods</topic><topic>Cerebral Cortex - physiology</topic><topic>Corpus Striatum - physiology</topic><topic>Dopamine receptor D2</topic><topic>Emotions - physiology</topic><topic>Facial Expression</topic><topic>Female</topic><topic>fMRI</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genotype</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Neural Pathways - physiology</topic><topic>Photic Stimulation - methods</topic><topic>Polymorphism</topic><topic>Polymorphism, Restriction Fragment Length</topic><topic>Protein-Serine-Threonine Kinases - genetics</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Receptors, Dopamine D2 - genetics</topic><topic>Striatum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Byeong-Taek</creatorcontrib><creatorcontrib>Lee, Hwa-Young</creatorcontrib><creatorcontrib>Han, Changsu</creatorcontrib><creatorcontrib>Pae, Chi-Un</creatorcontrib><creatorcontrib>Tae, Woo Suk</creatorcontrib><creatorcontrib>Lee, Min-Soo</creatorcontrib><creatorcontrib>Joe, Sook-Haeng</creatorcontrib><creatorcontrib>Jung, In-Kwa</creatorcontrib><creatorcontrib>Ham, Byung-Joo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><jtitle>Behavioural brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Byeong-Taek</au><au>Lee, Hwa-Young</au><au>Han, Changsu</au><au>Pae, Chi-Un</au><au>Tae, Woo Suk</au><au>Lee, Min-Soo</au><au>Joe, Sook-Haeng</au><au>Jung, In-Kwa</au><au>Ham, Byung-Joo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>DRD2/ANKK1 TaqI A polymorphism affects corticostriatal activity in response to negative affective facial stimuli</atitle><jtitle>Behavioural brain research</jtitle><addtitle>Behav Brain Res</addtitle><date>2011-09-30</date><risdate>2011</risdate><volume>223</volume><issue>1</issue><spage>36</spage><epage>41</epage><pages>36-41</pages><issn>0166-4328</issn><eissn>1872-7549</eissn><coden>BBREDI</coden><abstract>► DRD2/ANKK1
TaqI A polymorphism affects corticostriatal activity. ► Higher signal intensity in the homozygous group than in the heterozygous group. ► The molecular heterosis may play an important role in these responses.
DRD2/ANKK1
TaqI A polymorphism has been suggested to be involved in a reward-related psychiatric disorders. However, the effect of Dopamine receptor D2 (DRD2) on emotional processing has not been investigated yet. We investigated the possible relationship between DRD2/ANKK1
TaqI A polymorphism and corticostriatal response to negative facial stimuli using functional magnetic resonance imaging. All participants were genotyped with regard to the DRD2/ANKK1
TaqI A polymorphism. Our results suggest an association between the DRD2/ANKK1
TaqI A polymorphism and activations in the putamen, the anterior cingulate cortex, and amygdala in response to negative facial stimuli. Furthermore, molecular heterosis at the
TaqI polymorphism of DRD2/ANKK1 may play an important role in affective regulation by corticostriatal pathway.</abstract><cop>Shannon</cop><pub>Elsevier B.V</pub><pmid>21510979</pmid><doi>10.1016/j.bbr.2011.04.007</doi><tpages>6</tpages></addata></record> |
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| ispartof | Behavioural brain research, 2011-09, Vol.223 (1), p.36-41 |
| issn | 0166-4328 1872-7549 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Alleles Behavioral psychophysiology Biological and medical sciences Brain Mapping - methods Cerebral Cortex - physiology Corpus Striatum - physiology Dopamine receptor D2 Emotions - physiology Facial Expression Female fMRI Fundamental and applied biological sciences. Psychology Genotype Humans Magnetic Resonance Imaging - methods Neural Pathways - physiology Photic Stimulation - methods Polymorphism Polymorphism, Restriction Fragment Length Protein-Serine-Threonine Kinases - genetics Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Receptors, Dopamine D2 - genetics Striatum |
| title | DRD2/ANKK1 TaqI A polymorphism affects corticostriatal activity in response to negative affective facial stimuli |
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