Effect of bacterial metabolites on microsporidian Nosema ceranae and on its host Apis mellifera
Nosemosis, a disease caused by a microsporidian infection, is one of the most frequently observed parasitic pathologies affecting adult honeybees. Presently, Nosema ceranae seems to be the main microsporidian infection in Apis mellifera. The antibiotic fumagillin is the only compound available to tr...
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| Veröffentlicht in: | Parasitology research (1987) 2010-07, Vol.107 (2), p.381-388 |
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| container_title | Parasitology research (1987) |
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| creator | Porrini, Martín P Audisio, M. Carina Sabaté, Daniela C Ibarguren, Carolina Medici, Sandra K Sarlo, Edgardo G Garrido, P. Melisa Eguaras, Martín J |
| description | Nosemosis, a disease caused by a microsporidian infection, is one of the most frequently observed parasitic pathologies affecting adult honeybees. Presently, Nosema ceranae seems to be the main microsporidian infection in Apis mellifera. The antibiotic fumagillin is the only compound available to treat Nosema diseases; however, it is no longer licensed in most EU member states; therefore, the need to identify new molecules/substances prevails. The intent of this paper is to test bacterial metabolites by Bacillus and Enterococcus strains, isolated from bee midgut and honey. The toxicity on bees and the antiparasitic activity on N. ceranae were assessed under laboratory conditions. Results did not yield toxicity for the administered surfactin or bacteriocin concentrations. Spores exposed to direct contact with a particular surfactin revealed a significant infectivity reduction when inoculated on bees. This surfactin, administered ad libitum from the individuals' emergence, led to a significant reduction in parasitosis development when bees were infected with untreated spores 7 days postemergence. Based on the results obtained, one of the surfactins is herein postulated as a molecule capable of reducing N. ceranae development, acting either by direct exposure to purified spores or incorporated into the digestive tract of the bee. |
| doi_str_mv | 10.1007/s00436-010-1875-1 |
| format | Article |
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The toxicity on bees and the antiparasitic activity on N. ceranae were assessed under laboratory conditions. Results did not yield toxicity for the administered surfactin or bacteriocin concentrations. Spores exposed to direct contact with a particular surfactin revealed a significant infectivity reduction when inoculated on bees. This surfactin, administered ad libitum from the individuals' emergence, led to a significant reduction in parasitosis development when bees were infected with untreated spores 7 days postemergence. Based on the results obtained, one of the surfactins is herein postulated as a molecule capable of reducing N. ceranae development, acting either by direct exposure to purified spores or incorporated into the digestive tract of the bee.</description><identifier>ISSN: 0932-0113</identifier><identifier>EISSN: 1432-1955</identifier><identifier>DOI: 10.1007/s00436-010-1875-1</identifier><identifier>PMID: 20467753</identifier><identifier>CODEN: PARREZ</identifier><language>eng</language><publisher>Berlin/Heidelberg: Berlin/Heidelberg : Springer-Verlag</publisher><subject>Animal productions ; Animals ; Antifungal Agents - isolation & purification ; Antifungal Agents - pharmacology ; Antifungal Agents - toxicity ; Apiculture ; Apis mellifera ; Bacillus ; Bacillus - chemistry ; Bacillus - isolation & purification ; Bees - drug effects ; Bees - microbiology ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; DNA, Fungal - chemistry ; DNA, Fungal - genetics ; Enterococcus ; Enterococcus - chemistry ; Enterococcus - isolation & purification ; Fundamental and applied biological sciences. 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Carina</creatorcontrib><creatorcontrib>Sabaté, Daniela C</creatorcontrib><creatorcontrib>Ibarguren, Carolina</creatorcontrib><creatorcontrib>Medici, Sandra K</creatorcontrib><creatorcontrib>Sarlo, Edgardo G</creatorcontrib><creatorcontrib>Garrido, P. Melisa</creatorcontrib><creatorcontrib>Eguaras, Martín J</creatorcontrib><title>Effect of bacterial metabolites on microsporidian Nosema ceranae and on its host Apis mellifera</title><title>Parasitology research (1987)</title><addtitle>Parasitol Res</addtitle><addtitle>Parasitol Res</addtitle><description>Nosemosis, a disease caused by a microsporidian infection, is one of the most frequently observed parasitic pathologies affecting adult honeybees. Presently, Nosema ceranae seems to be the main microsporidian infection in Apis mellifera. The antibiotic fumagillin is the only compound available to treat Nosema diseases; however, it is no longer licensed in most EU member states; therefore, the need to identify new molecules/substances prevails. The intent of this paper is to test bacterial metabolites by Bacillus and Enterococcus strains, isolated from bee midgut and honey. The toxicity on bees and the antiparasitic activity on N. ceranae were assessed under laboratory conditions. Results did not yield toxicity for the administered surfactin or bacteriocin concentrations. Spores exposed to direct contact with a particular surfactin revealed a significant infectivity reduction when inoculated on bees. This surfactin, administered ad libitum from the individuals' emergence, led to a significant reduction in parasitosis development when bees were infected with untreated spores 7 days postemergence. 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Carina</au><au>Sabaté, Daniela C</au><au>Ibarguren, Carolina</au><au>Medici, Sandra K</au><au>Sarlo, Edgardo G</au><au>Garrido, P. Melisa</au><au>Eguaras, Martín J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of bacterial metabolites on microsporidian Nosema ceranae and on its host Apis mellifera</atitle><jtitle>Parasitology research (1987)</jtitle><stitle>Parasitol Res</stitle><addtitle>Parasitol Res</addtitle><date>2010-07-01</date><risdate>2010</risdate><volume>107</volume><issue>2</issue><spage>381</spage><epage>388</epage><pages>381-388</pages><issn>0932-0113</issn><eissn>1432-1955</eissn><coden>PARREZ</coden><abstract>Nosemosis, a disease caused by a microsporidian infection, is one of the most frequently observed parasitic pathologies affecting adult honeybees. Presently, Nosema ceranae seems to be the main microsporidian infection in Apis mellifera. The antibiotic fumagillin is the only compound available to treat Nosema diseases; however, it is no longer licensed in most EU member states; therefore, the need to identify new molecules/substances prevails. The intent of this paper is to test bacterial metabolites by Bacillus and Enterococcus strains, isolated from bee midgut and honey. The toxicity on bees and the antiparasitic activity on N. ceranae were assessed under laboratory conditions. Results did not yield toxicity for the administered surfactin or bacteriocin concentrations. Spores exposed to direct contact with a particular surfactin revealed a significant infectivity reduction when inoculated on bees. This surfactin, administered ad libitum from the individuals' emergence, led to a significant reduction in parasitosis development when bees were infected with untreated spores 7 days postemergence. 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| ispartof | Parasitology research (1987), 2010-07, Vol.107 (2), p.381-388 |
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| subjects | Animal productions Animals Antifungal Agents - isolation & purification Antifungal Agents - pharmacology Antifungal Agents - toxicity Apiculture Apis mellifera Bacillus Bacillus - chemistry Bacillus - isolation & purification Bees - drug effects Bees - microbiology Biological and medical sciences Biomedical and Life Sciences Biomedicine DNA, Fungal - chemistry DNA, Fungal - genetics Enterococcus Enterococcus - chemistry Enterococcus - isolation & purification Fundamental and applied biological sciences. Psychology Gastrointestinal Tract - microbiology General aspects General aspects and techniques. Study of several systematic groups. Models Immunology Insecta Invertebrates Lipopeptides - isolation & purification Lipopeptides - pharmacology Lipopeptides - toxicity Medical Microbiology Microbiology Molecular Sequence Data Nosema Nosema - drug effects Original Paper Peptides, Cyclic - isolation & purification Peptides, Cyclic - pharmacology Peptides, Cyclic - toxicity Sequence Analysis, DNA Terrestrial animal productions |
| title | Effect of bacterial metabolites on microsporidian Nosema ceranae and on its host Apis mellifera |
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