Visualizing the Molecular Interactions of a Nucleotide Analog, GS-9148, with HIV-1 Reverse Transcriptase–DNA Complex

GS-9148 ([5-(6-amino-purin-9-yl)-4-fluoro-2,5-dihydro-furan-2-yloxymethyl]-phosphonic acid) is a dAMP (2′-deoxyadenosine monophosphate) analog that maintains its antiviral activity against drug-resistant HIV. Crystal structures for HIV-1 reverse transcriptase (RT) bound to double-stranded DNA, terna...

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Veröffentlicht in:	Journal of molecular biology 2010-04, Vol.397 (4), p.967-978
Hauptverfasser:	Lansdon, Eric B., Samuel, Dharmaraj, Lagpacan, Leanna, Brendza, Katherine M., White, Kirsten L., Hung, Magdeleine, Liu, Xiaohong, Boojamra, Constantine G., Mackman, Richard L., Cihlar, Tomas, Ray, Adrian S., McGrath, Mary E., Swaminathan, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	antiretroviral therapy crystal structure Crystallography, X-Ray DNA - chemistry DNA - metabolism Drug Resistance, Viral Guanosine - analogs & derivatives Guanosine - metabolism HIV HIV Reverse Transcriptase - chemistry HIV Reverse Transcriptase - metabolism Human immunodeficiency virus 1 Models, Molecular Mutation, Missense NRTI Protein Binding Protein Structure, Tertiary reverse transcriptase Reverse Transcriptase Inhibitors - chemistry Reverse Transcriptase Inhibitors - metabolism
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