Obesity and Thyroid Cancer Risk among U.S. Men and Women: A Pooled Analysis of Five Prospective Studies
Thyroid cancer incidence has risen dramatically in the United States since the early 1980s. Although the prevalence of obesity has doubled during this time period, the relationship between obesity and thyroid cancer is uncertain. We examined the association between body mass index (BMI) and thyroid...
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| Veröffentlicht in: | Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2011-03, Vol.20 (3), p.464-472 |
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| creator | KITAHARA, Cari M PLATZ, Elizabeth A BEANE FREEMAN, Laura E HSING, Ann W LINET, Martha S PARK, Yikyung SCHAIRER, Catherine SCHATZKIN, Arthur SHIKANY, James M BERRINGTON DE GONZALEZ, Amy |
| description | Thyroid cancer incidence has risen dramatically in the United States since the early 1980s. Although the prevalence of obesity has doubled during this time period, the relationship between obesity and thyroid cancer is uncertain.
We examined the association between body mass index (BMI) and thyroid cancer risk in a pooled analysis of five prospective U.S. studies, including 413,979 women and 434,953 men. Proportional hazards models with attained age as the time metric were adjusted for education, race, marital status, smoking, alcohol intake, and (where appropriate) cohort and sex.
Over follow-up (mean=10.3 years), 768 women and 388 men were diagnosed with thyroid cancer. The risk of thyroid cancer was greater with increasing BMI [per 5 kg/m2: HR in women, 1.16 (95% CI, 1.08-1.24); HR in men, 1.21 (95% CI, 0.97-1.49)]. There was no significant heterogeneity between studies (both P>0.05). For women and men combined, the HRs for overweight (25.0-29.9 kg/m2) and obesity (≥30 kg/m2) compared with normal-weight (18.5-24.9 kg/m2) were 1.20 (95% CI, 1.04-1.38) and 1.53 (95% CI, 1.31-1.79), respectively. We found no significant effect modification by other factors, and the results did not differ significantly by histologic type. A significant positive association for BMI in young adulthood (ages 18-20) with thyroid cancer risk was also observed [per 5-kg/m2 increase: HR, 1.18 (95% CI, 1.03-1.35)].
BMI was positively associated with thyroid cancer risk in both men and women.
Our study provides strong evidence that obesity is an independent risk factor for thyroid cancer. |
| doi_str_mv | 10.1158/1055-9965.EPI-10-1220 |
| format | Article |
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We examined the association between body mass index (BMI) and thyroid cancer risk in a pooled analysis of five prospective U.S. studies, including 413,979 women and 434,953 men. Proportional hazards models with attained age as the time metric were adjusted for education, race, marital status, smoking, alcohol intake, and (where appropriate) cohort and sex.
Over follow-up (mean=10.3 years), 768 women and 388 men were diagnosed with thyroid cancer. The risk of thyroid cancer was greater with increasing BMI [per 5 kg/m2: HR in women, 1.16 (95% CI, 1.08-1.24); HR in men, 1.21 (95% CI, 0.97-1.49)]. There was no significant heterogeneity between studies (both P>0.05). For women and men combined, the HRs for overweight (25.0-29.9 kg/m2) and obesity (≥30 kg/m2) compared with normal-weight (18.5-24.9 kg/m2) were 1.20 (95% CI, 1.04-1.38) and 1.53 (95% CI, 1.31-1.79), respectively. We found no significant effect modification by other factors, and the results did not differ significantly by histologic type. A significant positive association for BMI in young adulthood (ages 18-20) with thyroid cancer risk was also observed [per 5-kg/m2 increase: HR, 1.18 (95% CI, 1.03-1.35)].
BMI was positively associated with thyroid cancer risk in both men and women.
Our study provides strong evidence that obesity is an independent risk factor for thyroid cancer.</description><identifier>ISSN: 1055-9965</identifier><identifier>EISSN: 1538-7755</identifier><identifier>DOI: 10.1158/1055-9965.EPI-10-1220</identifier><identifier>PMID: 21266520</identifier><identifier>CODEN: CEBPE4</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>Biological and medical sciences ; Body Mass Index ; Female ; Humans ; Male ; Medical sciences ; Metabolic diseases ; Middle Aged ; Obesity ; Obesity - epidemiology ; Proportional Hazards Models ; Prospective Studies ; Risk Factors ; Thyroid Neoplasms - epidemiology ; Tumors ; United States - epidemiology</subject><ispartof>Cancer epidemiology, biomarkers & prevention, 2011-03, Vol.20 (3), p.464-472</ispartof><rights>2015 INIST-CNRS</rights><rights>2011 AACR.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-f47c2b1a4265e87bb14de6f8a5f40ce503db25b84866b14f67aad6c4b7a7b3313</citedby><cites>FETCH-LOGICAL-c417t-f47c2b1a4265e87bb14de6f8a5f40ce503db25b84866b14f67aad6c4b7a7b3313</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3342,27902,27903</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23937697$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21266520$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KITAHARA, Cari M</creatorcontrib><creatorcontrib>PLATZ, Elizabeth A</creatorcontrib><creatorcontrib>BEANE FREEMAN, Laura E</creatorcontrib><creatorcontrib>HSING, Ann W</creatorcontrib><creatorcontrib>LINET, Martha S</creatorcontrib><creatorcontrib>PARK, Yikyung</creatorcontrib><creatorcontrib>SCHAIRER, Catherine</creatorcontrib><creatorcontrib>SCHATZKIN, Arthur</creatorcontrib><creatorcontrib>SHIKANY, James M</creatorcontrib><creatorcontrib>BERRINGTON DE GONZALEZ, Amy</creatorcontrib><title>Obesity and Thyroid Cancer Risk among U.S. Men and Women: A Pooled Analysis of Five Prospective Studies</title><title>Cancer epidemiology, biomarkers & prevention</title><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><description>Thyroid cancer incidence has risen dramatically in the United States since the early 1980s. Although the prevalence of obesity has doubled during this time period, the relationship between obesity and thyroid cancer is uncertain.
We examined the association between body mass index (BMI) and thyroid cancer risk in a pooled analysis of five prospective U.S. studies, including 413,979 women and 434,953 men. Proportional hazards models with attained age as the time metric were adjusted for education, race, marital status, smoking, alcohol intake, and (where appropriate) cohort and sex.
Over follow-up (mean=10.3 years), 768 women and 388 men were diagnosed with thyroid cancer. The risk of thyroid cancer was greater with increasing BMI [per 5 kg/m2: HR in women, 1.16 (95% CI, 1.08-1.24); HR in men, 1.21 (95% CI, 0.97-1.49)]. There was no significant heterogeneity between studies (both P>0.05). For women and men combined, the HRs for overweight (25.0-29.9 kg/m2) and obesity (≥30 kg/m2) compared with normal-weight (18.5-24.9 kg/m2) were 1.20 (95% CI, 1.04-1.38) and 1.53 (95% CI, 1.31-1.79), respectively. We found no significant effect modification by other factors, and the results did not differ significantly by histologic type. A significant positive association for BMI in young adulthood (ages 18-20) with thyroid cancer risk was also observed [per 5-kg/m2 increase: HR, 1.18 (95% CI, 1.03-1.35)].
BMI was positively associated with thyroid cancer risk in both men and women.
Our study provides strong evidence that obesity is an independent risk factor for thyroid cancer.</description><subject>Biological and medical sciences</subject><subject>Body Mass Index</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Middle Aged</subject><subject>Obesity</subject><subject>Obesity - epidemiology</subject><subject>Proportional Hazards Models</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Thyroid Neoplasms - epidemiology</subject><subject>Tumors</subject><subject>United States - epidemiology</subject><issn>1055-9965</issn><issn>1538-7755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMlOwzAQQC0EglL4BJAviFOKnXhJuFVVWaSiVhTEMbKdCRiSuMQJUv8etxQ4zWjmzaKH0BklI0p5ekUJ51GWCT6aLu4jSiIax2QPDShP0khKzvdD_sscoWPv3wkhMuP8EB3FNBaCx2SAXucavO3WWDUFfnpbt84WeKIaAy1-tP4Dq9o1r_h5tBzhB2i22IurobnGY7xwroICjxtVrb312JX4xn4BXrTOr8B0m3zZ9YUFf4IOSlV5ON3FIXq-mT5N7qLZ_PZ-Mp5FhlHZRSWTJtZUsVhwSKXWlBUgylTxkhEDnCSFjrlOWSpE6JVCKlUIw7RUUicJTYbo8mfvqnWfPfgur603UFWqAdf7PCOMSZYxEUj-Q5rwrW-hzFetrVW7zinJN4rzjb58oy8PirfVoDjMne8u9LqG4m_q12kALnaA8kZVZRtsWv_PJVkiRSaTb18_g14</recordid><startdate>20110301</startdate><enddate>20110301</enddate><creator>KITAHARA, Cari M</creator><creator>PLATZ, Elizabeth A</creator><creator>BEANE FREEMAN, Laura E</creator><creator>HSING, Ann W</creator><creator>LINET, Martha S</creator><creator>PARK, Yikyung</creator><creator>SCHAIRER, Catherine</creator><creator>SCHATZKIN, Arthur</creator><creator>SHIKANY, James M</creator><creator>BERRINGTON DE GONZALEZ, Amy</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope></search><sort><creationdate>20110301</creationdate><title>Obesity and Thyroid Cancer Risk among U.S. Men and Women: A Pooled Analysis of Five Prospective Studies</title><author>KITAHARA, Cari M ; PLATZ, Elizabeth A ; BEANE FREEMAN, Laura E ; HSING, Ann W ; LINET, Martha S ; PARK, Yikyung ; SCHAIRER, Catherine ; SCHATZKIN, Arthur ; SHIKANY, James M ; BERRINGTON DE GONZALEZ, Amy</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-f47c2b1a4265e87bb14de6f8a5f40ce503db25b84866b14f67aad6c4b7a7b3313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Biological and medical sciences</topic><topic>Body Mass Index</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Middle Aged</topic><topic>Obesity</topic><topic>Obesity - epidemiology</topic><topic>Proportional Hazards Models</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Thyroid Neoplasms - epidemiology</topic><topic>Tumors</topic><topic>United States - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>KITAHARA, Cari M</creatorcontrib><creatorcontrib>PLATZ, Elizabeth A</creatorcontrib><creatorcontrib>BEANE FREEMAN, Laura E</creatorcontrib><creatorcontrib>HSING, Ann W</creatorcontrib><creatorcontrib>LINET, Martha S</creatorcontrib><creatorcontrib>PARK, Yikyung</creatorcontrib><creatorcontrib>SCHAIRER, Catherine</creatorcontrib><creatorcontrib>SCHATZKIN, Arthur</creatorcontrib><creatorcontrib>SHIKANY, James M</creatorcontrib><creatorcontrib>BERRINGTON DE GONZALEZ, Amy</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>KITAHARA, Cari M</au><au>PLATZ, Elizabeth A</au><au>BEANE FREEMAN, Laura E</au><au>HSING, Ann W</au><au>LINET, Martha S</au><au>PARK, Yikyung</au><au>SCHAIRER, Catherine</au><au>SCHATZKIN, Arthur</au><au>SHIKANY, James M</au><au>BERRINGTON DE GONZALEZ, Amy</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Obesity and Thyroid Cancer Risk among U.S. Men and Women: A Pooled Analysis of Five Prospective Studies</atitle><jtitle>Cancer epidemiology, biomarkers & prevention</jtitle><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><date>2011-03-01</date><risdate>2011</risdate><volume>20</volume><issue>3</issue><spage>464</spage><epage>472</epage><pages>464-472</pages><issn>1055-9965</issn><eissn>1538-7755</eissn><coden>CEBPE4</coden><abstract>Thyroid cancer incidence has risen dramatically in the United States since the early 1980s. Although the prevalence of obesity has doubled during this time period, the relationship between obesity and thyroid cancer is uncertain.
We examined the association between body mass index (BMI) and thyroid cancer risk in a pooled analysis of five prospective U.S. studies, including 413,979 women and 434,953 men. Proportional hazards models with attained age as the time metric were adjusted for education, race, marital status, smoking, alcohol intake, and (where appropriate) cohort and sex.
Over follow-up (mean=10.3 years), 768 women and 388 men were diagnosed with thyroid cancer. The risk of thyroid cancer was greater with increasing BMI [per 5 kg/m2: HR in women, 1.16 (95% CI, 1.08-1.24); HR in men, 1.21 (95% CI, 0.97-1.49)]. There was no significant heterogeneity between studies (both P>0.05). For women and men combined, the HRs for overweight (25.0-29.9 kg/m2) and obesity (≥30 kg/m2) compared with normal-weight (18.5-24.9 kg/m2) were 1.20 (95% CI, 1.04-1.38) and 1.53 (95% CI, 1.31-1.79), respectively. We found no significant effect modification by other factors, and the results did not differ significantly by histologic type. A significant positive association for BMI in young adulthood (ages 18-20) with thyroid cancer risk was also observed [per 5-kg/m2 increase: HR, 1.18 (95% CI, 1.03-1.35)].
BMI was positively associated with thyroid cancer risk in both men and women.
Our study provides strong evidence that obesity is an independent risk factor for thyroid cancer.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>21266520</pmid><doi>10.1158/1055-9965.EPI-10-1220</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; American Association for Cancer Research; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Biological and medical sciences Body Mass Index Female Humans Male Medical sciences Metabolic diseases Middle Aged Obesity Obesity - epidemiology Proportional Hazards Models Prospective Studies Risk Factors Thyroid Neoplasms - epidemiology Tumors United States - epidemiology |
| title | Obesity and Thyroid Cancer Risk among U.S. Men and Women: A Pooled Analysis of Five Prospective Studies |
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