Safety of Antipsychotics in the Setting of QTc Prolongation: The Utility of the JT Index

Medication that prolongs cardiac repolarization may increase the risk for re-entrant ventricular arrhythmias, notably torsade de pointes, through the increased variability of heart rate corrected QT interval (QTc), or "QT dispersion" (1). QT and JT Interval Measurements With Left Bundle Br...

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Veröffentlicht in:	The American journal of psychiatry 2011-09, Vol.168 (9), p.990-991
Hauptverfasser:	Mukherji, Emily H., Bauer, Leah K., Leskov, Ilya, Januzzi, James Louis, Tanev, Kaloyan S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antipsychotic Agents - adverse effects Antipsychotic Agents - therapeutic use Aripiprazole Bipolar Disorder - drug therapy Bundle-Branch Block - complications Cardiac arrhythmia Combined Modality Therapy Cooperative Behavior Electrocardiography Electrocardiography - drug effects Electroconvulsive Therapy Female Haloperidol - adverse effects Haloperidol - therapeutic use Heart rate Humans Hypothyroidism Interdisciplinary Communication Long QT Syndrome - chemically induced Piperazines - therapeutic use Psychotropic drugs Quinolones - therapeutic use Risk Factors Torsades de Pointes - chemically induced Torsades de Pointes - prevention & control
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Zusammenfassung:	Medication that prolongs cardiac repolarization may increase the risk for re-entrant ventricular arrhythmias, notably torsade de pointes, through the increased variability of heart rate corrected QT interval (QTc), or "QT dispersion" (1). QT and JT Interval Measurements With Left Bundle Branch Block Case Report "Mrs. R" is a 77-year-old woman with bipolar disorder, hypothyroidism, coronary artery disease, and known left bundle branch block since at least 2003.
ISSN:	0002-953X 1535-7228
DOI:	10.1176/appi.ajp.2011.10121734