The Replicase Sliding Clamp Dynamically Accumulates behind Progressing Replication Forks in Bacillus subtilis Cells

The sliding clamp is an essential component of the replisome required for processivity of DNA synthesis and several other aspects of chromosome metabolism. However, the in vivo dynamics of the clamp are poorly understood. We have used various biochemical and cell biological methods to study the dyna...

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Veröffentlicht in:	Molecular cell 2011-03, Vol.41 (6), p.720-732
Hauptverfasser:	Su'etsugu, Masayuki, Errington, Jeff
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacillus subtilis Bacillus subtilis - cytology Bacillus subtilis - genetics Bacillus subtilis - metabolism Bacterial Proteins - genetics Bacterial Proteins - metabolism Computer Simulation DNA - chemistry DNA - genetics DNA - metabolism DNA Replication DNA-Directed DNA Polymerase - genetics DNA-Directed DNA Polymerase - metabolism Microscopy, Fluorescence - methods Models, Theoretical Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism
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