Geographic variation in the prevalence of Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly: a comparative analysis of a Mexican and a German population
Epstein–Barr virus (EBV)-positive diffuse large B-cell lymphoma of the elderly was included as a provisional entity in the 2008 WHO lymphoma classification. Most reports of this disease come from Asia and little is known about it in other regions of the world, including Latin America. Therefore, in...
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| Veröffentlicht in: | Modern pathology 2011-08, Vol.24 (8), p.1046-1054 |
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| creator | Hofscheier, Annegret Ponciano, Ana Bonzheim, Irina Adam, Patrick Lome-Maldonado, Carmen Vela, Teresa Cortes, Evelyn Ortiz-Hidalgo, Carlos Fend, Falko Quintanilla-Martinez, Leticia |
| description | Epstein–Barr virus (EBV)-positive diffuse large B-cell lymphoma of the elderly was included as a provisional entity in the 2008 WHO lymphoma classification. Most reports of this disease come from Asia and little is known about it in other regions of the world, including Latin America. Therefore, in this study, 305 diffuse large B-cell lymphomas in patients above 50 years were analyzed, 136 from Mexico and 169 from Germany. EBV was detected by Epstein–Barr early RNA (EBER)
in situ hybridization
. Only cases with EBER+ in the majority of tumor cells were regarded as EBV+ diffuse large B-cell lymphoma. The prevalence of EBV+ diffuse large B-cell lymphoma in Mexican patients was found to be 7% (9 of 136), whereas only 2% (4 of 169) of the German cases were positive. The median age at diagnosis was 66 years in the Mexican cohort, as opposed to 77 years in the German group. The site of presentation was in both groups predominantly nodal in nine cases (70%) and extranodal in four cases (30%). Of the 13 EBV+ cases, 10 (77%) were classified as polymorphic and 3 (23%) as monomorphic type. The polymorphic cases showed a non-germinal center B-cell immunophenotype (CD10− MUM1+). Twelve cases (92%) were LMP1 positive and two (15%) expressed EBNA2. An interesting finding was the high frequency of EBV type B with the
LMP1
30 bp deletion found in the Mexican cases (50%). Eight of the 11 evaluable cases were B-cell monoclonal by polymerase chain reaction. In summary, we found a similar prevalence of EBV+ diffuse large B-cell lymphoma of the elderly in a Mexican population compared with what has been reported in Asian countries, and in contrast to the low frequency in Western populations (1–3%). However, compared with the Asian series, the Mexican patients were younger at diagnosis, presented predominantly with nodal disease and rarely expressed EBNA2 protein. |
| doi_str_mv | 10.1038/modpathol.2011.62 |
| format | Article |
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in situ hybridization
. Only cases with EBER+ in the majority of tumor cells were regarded as EBV+ diffuse large B-cell lymphoma. The prevalence of EBV+ diffuse large B-cell lymphoma in Mexican patients was found to be 7% (9 of 136), whereas only 2% (4 of 169) of the German cases were positive. The median age at diagnosis was 66 years in the Mexican cohort, as opposed to 77 years in the German group. The site of presentation was in both groups predominantly nodal in nine cases (70%) and extranodal in four cases (30%). Of the 13 EBV+ cases, 10 (77%) were classified as polymorphic and 3 (23%) as monomorphic type. The polymorphic cases showed a non-germinal center B-cell immunophenotype (CD10− MUM1+). Twelve cases (92%) were LMP1 positive and two (15%) expressed EBNA2. An interesting finding was the high frequency of EBV type B with the
LMP1
30 bp deletion found in the Mexican cases (50%). Eight of the 11 evaluable cases were B-cell monoclonal by polymerase chain reaction. In summary, we found a similar prevalence of EBV+ diffuse large B-cell lymphoma of the elderly in a Mexican population compared with what has been reported in Asian countries, and in contrast to the low frequency in Western populations (1–3%). However, compared with the Asian series, the Mexican patients were younger at diagnosis, presented predominantly with nodal disease and rarely expressed EBNA2 protein.</description><identifier>ISSN: 0893-3952</identifier><identifier>EISSN: 1530-0285</identifier><identifier>DOI: 10.1038/modpathol.2011.62</identifier><identifier>PMID: 21499229</identifier><identifier>CODEN: MODPEO</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>631/326/596/1553 ; 692/699/67/1990/291/1621/1915 ; 692/700/1518 ; 692/700/478/174 ; Age of Onset ; Aged ; Epstein-Barr virus ; Epstein-Barr Virus Infections - epidemiology ; Epstein-Barr Virus Infections - etiology ; Epstein-Barr Virus Infections - pathology ; Epstein-Barr Virus Nuclear Antigens - analysis ; Epstein-Barr Virus Nuclear Antigens - biosynthesis ; Female ; Germany - epidemiology ; Herpesvirus 4, Human - genetics ; Humans ; In Situ Hybridization ; Laboratory Medicine ; Lymphoma, Large B-Cell, Diffuse - epidemiology ; Lymphoma, Large B-Cell, Diffuse - pathology ; Lymphoma, Large B-Cell, Diffuse - virology ; Male ; Medicine ; Medicine & Public Health ; Mexico - epidemiology ; Middle Aged ; original-article ; Pathology ; Polymerase Chain Reaction ; Prevalence ; Viral Matrix Proteins - analysis ; Viral Matrix Proteins - biosynthesis ; Viral Proteins - analysis ; Viral Proteins - biosynthesis</subject><ispartof>Modern pathology, 2011-08, Vol.24 (8), p.1046-1054</ispartof><rights>United States and Canadian Academy of Pathology, Inc. 2011</rights><rights>Copyright Nature Publishing Group Aug 2011</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c541t-75ff7d847c20ed37e9473e8c6364173c631387d4323f667584a62acdc76d3b983</citedby><cites>FETCH-LOGICAL-c541t-75ff7d847c20ed37e9473e8c6364173c631387d4323f667584a62acdc76d3b983</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/880234318?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,27915,27916,64374,64376,64378,72230</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21499229$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hofscheier, Annegret</creatorcontrib><creatorcontrib>Ponciano, Ana</creatorcontrib><creatorcontrib>Bonzheim, Irina</creatorcontrib><creatorcontrib>Adam, Patrick</creatorcontrib><creatorcontrib>Lome-Maldonado, Carmen</creatorcontrib><creatorcontrib>Vela, Teresa</creatorcontrib><creatorcontrib>Cortes, Evelyn</creatorcontrib><creatorcontrib>Ortiz-Hidalgo, Carlos</creatorcontrib><creatorcontrib>Fend, Falko</creatorcontrib><creatorcontrib>Quintanilla-Martinez, Leticia</creatorcontrib><title>Geographic variation in the prevalence of Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly: a comparative analysis of a Mexican and a German population</title><title>Modern pathology</title><addtitle>Mod Pathol</addtitle><addtitle>Mod Pathol</addtitle><description>Epstein–Barr virus (EBV)-positive diffuse large B-cell lymphoma of the elderly was included as a provisional entity in the 2008 WHO lymphoma classification. Most reports of this disease come from Asia and little is known about it in other regions of the world, including Latin America. Therefore, in this study, 305 diffuse large B-cell lymphomas in patients above 50 years were analyzed, 136 from Mexico and 169 from Germany. EBV was detected by Epstein–Barr early RNA (EBER)
in situ hybridization
. Only cases with EBER+ in the majority of tumor cells were regarded as EBV+ diffuse large B-cell lymphoma. The prevalence of EBV+ diffuse large B-cell lymphoma in Mexican patients was found to be 7% (9 of 136), whereas only 2% (4 of 169) of the German cases were positive. The median age at diagnosis was 66 years in the Mexican cohort, as opposed to 77 years in the German group. The site of presentation was in both groups predominantly nodal in nine cases (70%) and extranodal in four cases (30%). Of the 13 EBV+ cases, 10 (77%) were classified as polymorphic and 3 (23%) as monomorphic type. The polymorphic cases showed a non-germinal center B-cell immunophenotype (CD10− MUM1+). Twelve cases (92%) were LMP1 positive and two (15%) expressed EBNA2. An interesting finding was the high frequency of EBV type B with the
LMP1
30 bp deletion found in the Mexican cases (50%). Eight of the 11 evaluable cases were B-cell monoclonal by polymerase chain reaction. In summary, we found a similar prevalence of EBV+ diffuse large B-cell lymphoma of the elderly in a Mexican population compared with what has been reported in Asian countries, and in contrast to the low frequency in Western populations (1–3%). However, compared with the Asian series, the Mexican patients were younger at diagnosis, presented predominantly with nodal disease and rarely expressed EBNA2 protein.</description><subject>631/326/596/1553</subject><subject>692/699/67/1990/291/1621/1915</subject><subject>692/700/1518</subject><subject>692/700/478/174</subject><subject>Age of Onset</subject><subject>Aged</subject><subject>Epstein-Barr virus</subject><subject>Epstein-Barr Virus Infections - epidemiology</subject><subject>Epstein-Barr Virus Infections - etiology</subject><subject>Epstein-Barr Virus Infections - pathology</subject><subject>Epstein-Barr Virus Nuclear Antigens - analysis</subject><subject>Epstein-Barr Virus Nuclear Antigens - biosynthesis</subject><subject>Female</subject><subject>Germany - epidemiology</subject><subject>Herpesvirus 4, Human - genetics</subject><subject>Humans</subject><subject>In Situ Hybridization</subject><subject>Laboratory Medicine</subject><subject>Lymphoma, Large B-Cell, Diffuse - epidemiology</subject><subject>Lymphoma, Large B-Cell, Diffuse - 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Academic</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Modern pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hofscheier, Annegret</au><au>Ponciano, Ana</au><au>Bonzheim, Irina</au><au>Adam, Patrick</au><au>Lome-Maldonado, Carmen</au><au>Vela, Teresa</au><au>Cortes, Evelyn</au><au>Ortiz-Hidalgo, Carlos</au><au>Fend, Falko</au><au>Quintanilla-Martinez, Leticia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Geographic variation in the prevalence of Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly: a comparative analysis of a Mexican and a German population</atitle><jtitle>Modern pathology</jtitle><stitle>Mod Pathol</stitle><addtitle>Mod Pathol</addtitle><date>2011-08-01</date><risdate>2011</risdate><volume>24</volume><issue>8</issue><spage>1046</spage><epage>1054</epage><pages>1046-1054</pages><issn>0893-3952</issn><eissn>1530-0285</eissn><coden>MODPEO</coden><abstract>Epstein–Barr virus (EBV)-positive diffuse large B-cell lymphoma of the elderly was included as a provisional entity in the 2008 WHO lymphoma classification. Most reports of this disease come from Asia and little is known about it in other regions of the world, including Latin America. Therefore, in this study, 305 diffuse large B-cell lymphomas in patients above 50 years were analyzed, 136 from Mexico and 169 from Germany. EBV was detected by Epstein–Barr early RNA (EBER)
in situ hybridization
. Only cases with EBER+ in the majority of tumor cells were regarded as EBV+ diffuse large B-cell lymphoma. The prevalence of EBV+ diffuse large B-cell lymphoma in Mexican patients was found to be 7% (9 of 136), whereas only 2% (4 of 169) of the German cases were positive. The median age at diagnosis was 66 years in the Mexican cohort, as opposed to 77 years in the German group. The site of presentation was in both groups predominantly nodal in nine cases (70%) and extranodal in four cases (30%). Of the 13 EBV+ cases, 10 (77%) were classified as polymorphic and 3 (23%) as monomorphic type. The polymorphic cases showed a non-germinal center B-cell immunophenotype (CD10− MUM1+). Twelve cases (92%) were LMP1 positive and two (15%) expressed EBNA2. An interesting finding was the high frequency of EBV type B with the
LMP1
30 bp deletion found in the Mexican cases (50%). Eight of the 11 evaluable cases were B-cell monoclonal by polymerase chain reaction. In summary, we found a similar prevalence of EBV+ diffuse large B-cell lymphoma of the elderly in a Mexican population compared with what has been reported in Asian countries, and in contrast to the low frequency in Western populations (1–3%). However, compared with the Asian series, the Mexican patients were younger at diagnosis, presented predominantly with nodal disease and rarely expressed EBNA2 protein.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>21499229</pmid><doi>10.1038/modpathol.2011.62</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 631/326/596/1553 692/699/67/1990/291/1621/1915 692/700/1518 692/700/478/174 Age of Onset Aged Epstein-Barr virus Epstein-Barr Virus Infections - epidemiology Epstein-Barr Virus Infections - etiology Epstein-Barr Virus Infections - pathology Epstein-Barr Virus Nuclear Antigens - analysis Epstein-Barr Virus Nuclear Antigens - biosynthesis Female Germany - epidemiology Herpesvirus 4, Human - genetics Humans In Situ Hybridization Laboratory Medicine Lymphoma, Large B-Cell, Diffuse - epidemiology Lymphoma, Large B-Cell, Diffuse - pathology Lymphoma, Large B-Cell, Diffuse - virology Male Medicine Medicine & Public Health Mexico - epidemiology Middle Aged original-article Pathology Polymerase Chain Reaction Prevalence Viral Matrix Proteins - analysis Viral Matrix Proteins - biosynthesis Viral Proteins - analysis Viral Proteins - biosynthesis |
| title | Geographic variation in the prevalence of Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly: a comparative analysis of a Mexican and a German population |
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