Spontaneous resolution of hemophagocytic syndrome associated with acute parvovirus B19 infection and concomitant Epstein-Barr virus reactivation in an otherwise healthy adult
Reported here is the case of a patient who spontaneously recovered from hemophagocytic syndrome associated with acute B19 infection and concomitant Epstein-Barr virus reactivation. The previously healthy 37-year-old-man was hospitalized after 10 days of high fever, arthralgia and arthritis and was d...
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| Veröffentlicht in: | European journal of clinical microbiology & infectious diseases 2002-10, Vol.21 (10), p.739-742 |
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| container_title | European journal of clinical microbiology & infectious diseases |
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| creator | LARROCHE, C SCIEUX, C HONDERLICK, P PIETTE, A. M MORINET, F BLETRY, O |
| description | Reported here is the case of a patient who spontaneously recovered from hemophagocytic syndrome associated with acute B19 infection and concomitant Epstein-Barr virus reactivation. The previously healthy 37-year-old-man was hospitalized after 10 days of high fever, arthralgia and arthritis and was determined to have hemophagocytic syndrome. Immunoglobulin (Ig) M antibodies to Epstein-Barr virus (EBV) capsid antigen, early antigen and parvovirus B19 (B19) were found. B19 DNA and low-level EBV DNA were detected in bone marrow, serum and peripheral blood mononuclear cells. The patient recovered spontaneously without any treatment. Two months later anti-B19 IgG antibodies were detected, while at 9-month follow-up, anti-B19 IgM antibodies were no longer detectable and B19 DNA had disappeared from serum. To the best of our knowledge, this is the first report of spontaneous resolution of hemophagocytic syndrome associated with acute B19 infection and concomitant EBV reactivation in an otherwise healthy adult. |
| doi_str_mv | 10.1007/s10096-002-0793-2 |
| format | Article |
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M ; MORINET, F ; BLETRY, O</creator><creatorcontrib>LARROCHE, C ; SCIEUX, C ; HONDERLICK, P ; PIETTE, A. M ; MORINET, F ; BLETRY, O</creatorcontrib><description>Reported here is the case of a patient who spontaneously recovered from hemophagocytic syndrome associated with acute B19 infection and concomitant Epstein-Barr virus reactivation. The previously healthy 37-year-old-man was hospitalized after 10 days of high fever, arthralgia and arthritis and was determined to have hemophagocytic syndrome. Immunoglobulin (Ig) M antibodies to Epstein-Barr virus (EBV) capsid antigen, early antigen and parvovirus B19 (B19) were found. B19 DNA and low-level EBV DNA were detected in bone marrow, serum and peripheral blood mononuclear cells. The patient recovered spontaneously without any treatment. Two months later anti-B19 IgG antibodies were detected, while at 9-month follow-up, anti-B19 IgM antibodies were no longer detectable and B19 DNA had disappeared from serum. To the best of our knowledge, this is the first report of spontaneous resolution of hemophagocytic syndrome associated with acute B19 infection and concomitant EBV reactivation in an otherwise healthy adult.</description><identifier>ISSN: 0934-9723</identifier><identifier>EISSN: 1435-4373</identifier><identifier>DOI: 10.1007/s10096-002-0793-2</identifier><identifier>PMID: 12415473</identifier><language>eng</language><publisher>Berlin: Springer</publisher><subject>Acute Disease ; Adult ; Antibodies ; Antigens ; Arthralgia ; Arthritis ; Biological and medical sciences ; Bone marrow ; Deoxyribonucleic acid ; DNA ; Epstein-Barr virus ; Epstein-Barr Virus Infections - complications ; Epstein-Barr Virus Infections - diagnosis ; Epstein-Barr Virus Infections - immunology ; Fever ; Follow-Up Studies ; Hemophagocytic syndrome ; Histiocytosis, Non-Langerhans-Cell - complications ; Histiocytosis, Non-Langerhans-Cell - diagnosis ; Histiocytosis, Non-Langerhans-Cell - immunology ; Human viral diseases ; Humans ; Immunocompetence ; Immunoglobulin G ; Immunoglobulin M ; Infectious diseases ; Leukocytes (mononuclear) ; Male ; Medical sciences ; Parvoviridae Infections - complications ; Parvoviridae Infections - diagnosis ; Parvoviridae Infections - immunology ; Parvovirus B19 ; Parvovirus B19, Human - isolation & purification ; Parvoviruses ; Patients ; Peripheral blood mononuclear cells ; Remission, Spontaneous ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. Aids ; Viruses</subject><ispartof>European journal of clinical microbiology & infectious diseases, 2002-10, Vol.21 (10), p.739-742</ispartof><rights>2003 INIST-CNRS</rights><rights>Springer-Verlag 2002.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c414t-9c4772ac8ddcbeb1a16472713811a3a183c4737bd5a9358b398b1ae71623f01c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14015993$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12415473$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LARROCHE, C</creatorcontrib><creatorcontrib>SCIEUX, C</creatorcontrib><creatorcontrib>HONDERLICK, P</creatorcontrib><creatorcontrib>PIETTE, A. M</creatorcontrib><creatorcontrib>MORINET, F</creatorcontrib><creatorcontrib>BLETRY, O</creatorcontrib><title>Spontaneous resolution of hemophagocytic syndrome associated with acute parvovirus B19 infection and concomitant Epstein-Barr virus reactivation in an otherwise healthy adult</title><title>European journal of clinical microbiology & infectious diseases</title><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><description>Reported here is the case of a patient who spontaneously recovered from hemophagocytic syndrome associated with acute B19 infection and concomitant Epstein-Barr virus reactivation. The previously healthy 37-year-old-man was hospitalized after 10 days of high fever, arthralgia and arthritis and was determined to have hemophagocytic syndrome. Immunoglobulin (Ig) M antibodies to Epstein-Barr virus (EBV) capsid antigen, early antigen and parvovirus B19 (B19) were found. B19 DNA and low-level EBV DNA were detected in bone marrow, serum and peripheral blood mononuclear cells. The patient recovered spontaneously without any treatment. Two months later anti-B19 IgG antibodies were detected, while at 9-month follow-up, anti-B19 IgM antibodies were no longer detectable and B19 DNA had disappeared from serum. To the best of our knowledge, this is the first report of spontaneous resolution of hemophagocytic syndrome associated with acute B19 infection and concomitant EBV reactivation in an otherwise healthy adult.</description><subject>Acute Disease</subject><subject>Adult</subject><subject>Antibodies</subject><subject>Antigens</subject><subject>Arthralgia</subject><subject>Arthritis</subject><subject>Biological and medical sciences</subject><subject>Bone marrow</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>Epstein-Barr virus</subject><subject>Epstein-Barr Virus Infections - complications</subject><subject>Epstein-Barr Virus Infections - diagnosis</subject><subject>Epstein-Barr Virus Infections - immunology</subject><subject>Fever</subject><subject>Follow-Up Studies</subject><subject>Hemophagocytic syndrome</subject><subject>Histiocytosis, Non-Langerhans-Cell - complications</subject><subject>Histiocytosis, Non-Langerhans-Cell - diagnosis</subject><subject>Histiocytosis, Non-Langerhans-Cell - immunology</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immunocompetence</subject><subject>Immunoglobulin G</subject><subject>Immunoglobulin M</subject><subject>Infectious diseases</subject><subject>Leukocytes (mononuclear)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Parvoviridae Infections - complications</subject><subject>Parvoviridae Infections - diagnosis</subject><subject>Parvoviridae Infections - immunology</subject><subject>Parvovirus B19</subject><subject>Parvovirus B19, Human - isolation & purification</subject><subject>Parvoviruses</subject><subject>Patients</subject><subject>Peripheral blood mononuclear cells</subject><subject>Remission, Spontaneous</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. 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M</au><au>MORINET, F</au><au>BLETRY, O</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Spontaneous resolution of hemophagocytic syndrome associated with acute parvovirus B19 infection and concomitant Epstein-Barr virus reactivation in an otherwise healthy adult</atitle><jtitle>European journal of clinical microbiology & infectious diseases</jtitle><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><date>2002-10-01</date><risdate>2002</risdate><volume>21</volume><issue>10</issue><spage>739</spage><epage>742</epage><pages>739-742</pages><issn>0934-9723</issn><eissn>1435-4373</eissn><abstract>Reported here is the case of a patient who spontaneously recovered from hemophagocytic syndrome associated with acute B19 infection and concomitant Epstein-Barr virus reactivation. The previously healthy 37-year-old-man was hospitalized after 10 days of high fever, arthralgia and arthritis and was determined to have hemophagocytic syndrome. Immunoglobulin (Ig) M antibodies to Epstein-Barr virus (EBV) capsid antigen, early antigen and parvovirus B19 (B19) were found. B19 DNA and low-level EBV DNA were detected in bone marrow, serum and peripheral blood mononuclear cells. The patient recovered spontaneously without any treatment. Two months later anti-B19 IgG antibodies were detected, while at 9-month follow-up, anti-B19 IgM antibodies were no longer detectable and B19 DNA had disappeared from serum. To the best of our knowledge, this is the first report of spontaneous resolution of hemophagocytic syndrome associated with acute B19 infection and concomitant EBV reactivation in an otherwise healthy adult.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>12415473</pmid><doi>10.1007/s10096-002-0793-2</doi><tpages>4</tpages></addata></record> |
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| ispartof | European journal of clinical microbiology & infectious diseases, 2002-10, Vol.21 (10), p.739-742 |
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| subjects | Acute Disease Adult Antibodies Antigens Arthralgia Arthritis Biological and medical sciences Bone marrow Deoxyribonucleic acid DNA Epstein-Barr virus Epstein-Barr Virus Infections - complications Epstein-Barr Virus Infections - diagnosis Epstein-Barr Virus Infections - immunology Fever Follow-Up Studies Hemophagocytic syndrome Histiocytosis, Non-Langerhans-Cell - complications Histiocytosis, Non-Langerhans-Cell - diagnosis Histiocytosis, Non-Langerhans-Cell - immunology Human viral diseases Humans Immunocompetence Immunoglobulin G Immunoglobulin M Infectious diseases Leukocytes (mononuclear) Male Medical sciences Parvoviridae Infections - complications Parvoviridae Infections - diagnosis Parvoviridae Infections - immunology Parvovirus B19 Parvovirus B19, Human - isolation & purification Parvoviruses Patients Peripheral blood mononuclear cells Remission, Spontaneous Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viruses |
| title | Spontaneous resolution of hemophagocytic syndrome associated with acute parvovirus B19 infection and concomitant Epstein-Barr virus reactivation in an otherwise healthy adult |
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