Enhanced Safety Profiles of the Telomerase-Specific Replication-Competent Adenovirus by Incorporation of Normal Cell-Specific microRNA-Targeted Sequences

Oncolytic adenoviruses (Ad) have been actively pursued as potential agents for cancer treatment. Among the various types of oncolytic Ads, the telomerase-specific replication-competent Ad (TRAD), which possesses an E1 gene expression cassette driven by the human telomerase reverse transcriptase prom...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Clinical cancer research 2011-05, Vol.17 (9), p.2807-2818
Hauptverfasser:	SUGIO, Kumiko, SAKURAI, Fuminori, MIZUGUCHI, Hiroyuki, KATAYAMA, Kazufumi, TASHIRO, Katsuhisa, MATSUI, Hayato, KAWABATA, Kenji, KAWASE, Atsushi, IWAKI, Masahiro, HAYAKAWA, Takao, FUJIWARA, Toshiyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Adenoviridae - metabolism Adenovirus Antineoplastic agents Biological and medical sciences Cells - metabolism Cells, Cultured Cloning, Molecular Gene Targeting - methods Genetic Vectors - adverse effects Genetic Vectors - genetics Hep G2 Cells HT29 Cells Humans Medical sciences MicroRNAs - genetics MicroRNAs - physiology Neoplasms - genetics Neoplasms - therapy Oncolytic Virotherapy - adverse effects Oncolytic Virotherapy - methods Oncolytic Viruses - genetics Oncolytic Viruses - physiology Organisms, Genetically Modified Pharmacology. Drug treatments Regulatory Sequences, Nucleic Acid - genetics Substrate Specificity Telomerase - metabolism Telomerase - physiology Virus Replication - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!