Proteases and bone remodelling
Abstract Bone remodelling is regulated by osteogenic cells which act individually through cellular and molecular interaction. These interactions can be established either through a cell–cell contact, involving molecules of the integrin family, or by the release of many polypeptidic factors and/or th...
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| Veröffentlicht in: | Cytokine & growth factor reviews 2009-02, Vol.20 (1), p.29-41 |
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| creator | Georges, S Ruiz Velasco, C Trichet, V Fortun, Y Heymann, D Padrines, M |
| description | Abstract Bone remodelling is regulated by osteogenic cells which act individually through cellular and molecular interaction. These interactions can be established either through a cell–cell contact, involving molecules of the integrin family, or by the release of many polypeptidic factors and/or their soluble receptor chains. Proteolytic shedding of membrane-associated proteins regulates the physiological activity of numerous proteins. Proteases located on the plasma membrane, either as transmembrane proteins or anchored to cell-surface molecules, serve as activators or inhibitors of different cellular and physiological processes. This review will focus on the role of the proteases implicated in bone remodelling either through the proteolytic degradation of the extracellular matrix or through their relations with osteogenic factors. Their implication in bone tumor progression will be also considered. |
| doi_str_mv | 10.1016/j.cytogfr.2008.11.005 |
| format | Article |
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These interactions can be established either through a cell–cell contact, involving molecules of the integrin family, or by the release of many polypeptidic factors and/or their soluble receptor chains. Proteolytic shedding of membrane-associated proteins regulates the physiological activity of numerous proteins. Proteases located on the plasma membrane, either as transmembrane proteins or anchored to cell-surface molecules, serve as activators or inhibitors of different cellular and physiological processes. This review will focus on the role of the proteases implicated in bone remodelling either through the proteolytic degradation of the extracellular matrix or through their relations with osteogenic factors. Their implication in bone tumor progression will be also considered.</description><subject>Advanced Basic Science</subject><subject>Animals</subject><subject>Bone Matrix - metabolism</subject><subject>Bone Neoplasms - metabolism</subject><subject>Bone Neoplasms - pathology</subject><subject>Bone Remodeling</subject><subject>Bone remodelling</subject><subject>Cathepsin K</subject><subject>Cathepsins - metabolism</subject><subject>Cell Membrane - metabolism</subject><subject>Cytokines - metabolism</subject><subject>Disease Progression</subject><subject>Extracellular Matrix - metabolism</subject><subject>Humans</subject><subject>Integrins - metabolism</subject><subject>Intercellular Signaling Peptides and Proteins - metabolism</subject><subject>Metalloproteases - metabolism</subject><subject>Metalloproteinases</subject><subject>Models, Biological</subject><subject>Peptide Hydrolases - physiology</subject><subject>Protease</subject><issn>1359-6101</issn><issn>1879-0305</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV1LwzAUhoMobk5_gmN3XrWe0zRpe6PI8AsGCup1aJPT0do1M-mE_XszNhC88Sq5eM7X8zJ2iRAjoLxuY70d7LJ2cQKQx4gxgDhiY8yzIgIO4jj8uSgiGfARO_O-BYCUCzhlIywgxSTLxmz66uxApSc_K3szq2xPM0cra6jrmn55zk7qsvN0cXgn7OPh_n3-FC1eHp_nd4tIpwKGSCMvDa-qtMhEKqUUJUFW18aIhGtZV3nNq0KjJMk1zwETkxSUoYQ8qXRBwCfsat937ezXhvygVo3XYYeyJ7vxKuybZuEoDKTYk9pZ7x3Vau2aVem2CkHtzKhWHcyonRmFqIKZUDc9TNhUKzK_VQcVAbjdAxTu_G7IKa8b6jWZxpEelLHNvyNu_nTQwWGjy-6TtuRbu3F9kKhQ-USBetvFs0sH8pBMlhb8B0s0ilw</recordid><startdate>20090201</startdate><enddate>20090201</enddate><creator>Georges, S</creator><creator>Ruiz Velasco, C</creator><creator>Trichet, V</creator><creator>Fortun, Y</creator><creator>Heymann, D</creator><creator>Padrines, M</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope></search><sort><creationdate>20090201</creationdate><title>Proteases and bone remodelling</title><author>Georges, S ; Ruiz Velasco, C ; Trichet, V ; Fortun, Y ; Heymann, D ; Padrines, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-c13ad3bb497546665ae07ffdd523c6fb8f3b9c16e63c38012d29e716082bc9e03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Advanced Basic Science</topic><topic>Animals</topic><topic>Bone Matrix - metabolism</topic><topic>Bone Neoplasms - metabolism</topic><topic>Bone Neoplasms - pathology</topic><topic>Bone Remodeling</topic><topic>Bone remodelling</topic><topic>Cathepsin K</topic><topic>Cathepsins - metabolism</topic><topic>Cell Membrane - metabolism</topic><topic>Cytokines - metabolism</topic><topic>Disease Progression</topic><topic>Extracellular Matrix - metabolism</topic><topic>Humans</topic><topic>Integrins - metabolism</topic><topic>Intercellular Signaling Peptides and Proteins - metabolism</topic><topic>Metalloproteases - metabolism</topic><topic>Metalloproteinases</topic><topic>Models, Biological</topic><topic>Peptide Hydrolases - physiology</topic><topic>Protease</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Georges, S</creatorcontrib><creatorcontrib>Ruiz Velasco, C</creatorcontrib><creatorcontrib>Trichet, V</creatorcontrib><creatorcontrib>Fortun, Y</creatorcontrib><creatorcontrib>Heymann, D</creatorcontrib><creatorcontrib>Padrines, M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><jtitle>Cytokine & growth factor reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Georges, S</au><au>Ruiz Velasco, C</au><au>Trichet, V</au><au>Fortun, Y</au><au>Heymann, D</au><au>Padrines, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Proteases and bone remodelling</atitle><jtitle>Cytokine & growth factor reviews</jtitle><addtitle>Cytokine Growth Factor Rev</addtitle><date>2009-02-01</date><risdate>2009</risdate><volume>20</volume><issue>1</issue><spage>29</spage><epage>41</epage><pages>29-41</pages><issn>1359-6101</issn><eissn>1879-0305</eissn><abstract>Abstract Bone remodelling is regulated by osteogenic cells which act individually through cellular and molecular interaction. 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| subjects | Advanced Basic Science Animals Bone Matrix - metabolism Bone Neoplasms - metabolism Bone Neoplasms - pathology Bone Remodeling Bone remodelling Cathepsin K Cathepsins - metabolism Cell Membrane - metabolism Cytokines - metabolism Disease Progression Extracellular Matrix - metabolism Humans Integrins - metabolism Intercellular Signaling Peptides and Proteins - metabolism Metalloproteases - metabolism Metalloproteinases Models, Biological Peptide Hydrolases - physiology Protease |
| title | Proteases and bone remodelling |
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