Synthesis, Structure, DNA-Binding Properties, and Cytotoxicity of Ruthenium(II) Polypyridyl Complexes

Many ruthenium(II) complexes show high antitumor activities, and the in vitro antitumor activities are usually related to DNA binding. We designed and synthesized two RuII polypyridyl complexes, [Ru(dmp)2(fpp)]2+ (dmp=2,9‐dimethyl‐1,10‐phenanthroline; fpp=2‐[3,4‐(difluoromethylenedioxy)phenyl]imidaz...

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Veröffentlicht in:	Chemistry & biodiversity 2010-07, Vol.7 (7), p.1770-1783
Hauptverfasser:	Liu, Yun-Jun, Zeng, Cheng-Hui, Yao, Jun-Hua, Wu, Fu-Hai, He, Li-Xin, Huang, Hong-Liang
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antitumor activity Cell Line, Tumor Cell Survival - drug effects DNA - metabolism DNA Binding Humans Models, Molecular Molecular Structure Neoplasms - drug therapy Nucleic Acid Denaturation - drug effects Phenanthrolines - chemical synthesis Phenanthrolines - chemistry Phenanthrolines - pharmacology Photochemical Processes - drug effects Ruthenium complexes Ruthenium Compounds - chemical synthesis Ruthenium Compounds - chemistry Ruthenium Compounds - pharmacology Viscosity - drug effects
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