Use of iodine-123 metaiodobenzylguanidine scintigraphy for the detection of amiodarone induced pulmonary toxicity in a rabbit model: a comparative study with technetium-99m diethyltriaminepenta acetic acid radioaerosol scintigraphy
The purpose of the study was; (i) to determine whether 123I-MIBG scintigraphy is sensitive for detection of amiodarone induced pulmonary toxicity (AIPT) and (ii) to compare it with 99mTc-DTPA radioaerosol. Twelve white New Zealand rabbit with initial mean body weight 4.24 +/- 0.47 g were divided int...
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| Veröffentlicht in: | Annals of nuclear medicine 2005-05, Vol.19 (3), p.217-224 |
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| creator | Durmuş-Altun, Gulay Altun, Armagan Aktas, Ranan Gülhan Salihoglu, Yavuz Sami Yigitbasi, Necmi Omer |
| description | The purpose of the study was; (i) to determine whether 123I-MIBG scintigraphy is sensitive for detection of amiodarone induced pulmonary toxicity (AIPT) and (ii) to compare it with 99mTc-DTPA radioaerosol. Twelve white New Zealand rabbit with initial mean body weight 4.24 +/- 0.47 g were divided into two groups. AIPT group (n = 7) was administered amiodarone (20 mg/kg BW). The control group (n = 5) received the same amount of 0.9% saline. All animals underwent 123I-MIBG and 99mTc-DTPA radioaerosol scintigraphy at the end of the treatment period. 123I-MIBG static thorax images were obtained during 10 minutes at 15 minutes and 3-hours after intravenous injection of the radiopharmaceutical. Lung to heart ratios (LHR) and lung to mediastinum ratios (LMR), and retention index (LRI) of 123I-MIBG were determined. Two days after 123I-MIBG scintigraphy, 99mTc-DTPA radioaerosol scintigraphy was performed, and clearance from the lungs was measured for 10 min (1 min/frame) following termination of inhalation. 123I-MIBG lung retention index (LRI) was significantly higher in the AIPT group than the control (61 +/- 4.6 vs. 40 +/- 4.5, p = 0.01). Early LHR and LMR were significantly lower in the AIPT group than in the control group (p = 0.04, p = 0.01, respectively), whereas those of late LHR and LMR were not significantly different. T1/2 values of DTPA clearance were significantly increased in AIPT group according to the control group (55 +/- 7.2 vs. 86.6 +/- 18.5, p = 0.02). 123I-MIBG scintigraphy is a valuable tool for detecting AIPT in a rabbit model. Additionally, 99mTc-DTPA radioaerosol scintigraphy is an excellent comprehensive investigational tool for detecting AIPT with the added advantage of lower cost. |
| doi_str_mv | 10.1007/BF02984608 |
| format | Article |
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Twelve white New Zealand rabbit with initial mean body weight 4.24 +/- 0.47 g were divided into two groups. AIPT group (n = 7) was administered amiodarone (20 mg/kg BW). The control group (n = 5) received the same amount of 0.9% saline. All animals underwent 123I-MIBG and 99mTc-DTPA radioaerosol scintigraphy at the end of the treatment period. 123I-MIBG static thorax images were obtained during 10 minutes at 15 minutes and 3-hours after intravenous injection of the radiopharmaceutical. Lung to heart ratios (LHR) and lung to mediastinum ratios (LMR), and retention index (LRI) of 123I-MIBG were determined. Two days after 123I-MIBG scintigraphy, 99mTc-DTPA radioaerosol scintigraphy was performed, and clearance from the lungs was measured for 10 min (1 min/frame) following termination of inhalation. 123I-MIBG lung retention index (LRI) was significantly higher in the AIPT group than the control (61 +/- 4.6 vs. 40 +/- 4.5, p = 0.01). Early LHR and LMR were significantly lower in the AIPT group than in the control group (p = 0.04, p = 0.01, respectively), whereas those of late LHR and LMR were not significantly different. T1/2 values of DTPA clearance were significantly increased in AIPT group according to the control group (55 +/- 7.2 vs. 86.6 +/- 18.5, p = 0.02). 123I-MIBG scintigraphy is a valuable tool for detecting AIPT in a rabbit model. Additionally, 99mTc-DTPA radioaerosol scintigraphy is an excellent comprehensive investigational tool for detecting AIPT with the added advantage of lower cost.</description><identifier>ISSN: 0914-7187</identifier><identifier>EISSN: 1864-6433</identifier><identifier>DOI: 10.1007/BF02984608</identifier><identifier>PMID: 15981675</identifier><language>eng</language><publisher>Japan: Springer Nature B.V</publisher><subject>3-Iodobenzylguanidine ; Acetic acid ; Aerosols ; Amiodarone ; Amiodarone - adverse effects ; Amiodarone - therapeutic use ; Animals ; Anti-Arrhythmia Agents - adverse effects ; Anti-Arrhythmia Agents - therapeutic use ; Body weight ; Comparative studies ; Inhalation ; Injections, Intravenous ; Iodine ; Iodine isotopes ; Lung - diagnostic imaging ; Lung - drug effects ; Lung - pathology ; Lung Diseases - chemically induced ; Lung Diseases - diagnostic imaging ; Lung Diseases - pathology ; Lungs ; Mediastinum ; Medical imaging ; Pharmaceuticals ; Rabbits ; Radiochemistry ; Radioisotopes ; Radionuclide Imaging ; Radiopharmaceuticals ; Reproducibility of Results ; Respiration ; Scintigraphy ; Sensitivity and Specificity ; Technetium ; Technetium isotopes ; Technetium Tc 99m Pentetate ; Thorax ; Toxicity</subject><ispartof>Annals of nuclear medicine, 2005-05, Vol.19 (3), p.217-224</ispartof><rights>Springer 2005</rights><rights>Springer 2005.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-b4ce24ddc23a25bb394e47e1c7941a2e15051a8239b772b94d5afcb6d2620dea3</citedby><cites>FETCH-LOGICAL-c456t-b4ce24ddc23a25bb394e47e1c7941a2e15051a8239b772b94d5afcb6d2620dea3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15981675$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Durmuş-Altun, Gulay</creatorcontrib><creatorcontrib>Altun, Armagan</creatorcontrib><creatorcontrib>Aktas, Ranan Gülhan</creatorcontrib><creatorcontrib>Salihoglu, Yavuz Sami</creatorcontrib><creatorcontrib>Yigitbasi, Necmi Omer</creatorcontrib><title>Use of iodine-123 metaiodobenzylguanidine scintigraphy for the detection of amiodarone induced pulmonary toxicity in a rabbit model: a comparative study with technetium-99m diethyltriaminepenta acetic acid radioaerosol scintigraphy</title><title>Annals of nuclear medicine</title><addtitle>Ann Nucl Med</addtitle><description>The purpose of the study was; (i) to determine whether 123I-MIBG scintigraphy is sensitive for detection of amiodarone induced pulmonary toxicity (AIPT) and (ii) to compare it with 99mTc-DTPA radioaerosol. Twelve white New Zealand rabbit with initial mean body weight 4.24 +/- 0.47 g were divided into two groups. AIPT group (n = 7) was administered amiodarone (20 mg/kg BW). The control group (n = 5) received the same amount of 0.9% saline. All animals underwent 123I-MIBG and 99mTc-DTPA radioaerosol scintigraphy at the end of the treatment period. 123I-MIBG static thorax images were obtained during 10 minutes at 15 minutes and 3-hours after intravenous injection of the radiopharmaceutical. Lung to heart ratios (LHR) and lung to mediastinum ratios (LMR), and retention index (LRI) of 123I-MIBG were determined. Two days after 123I-MIBG scintigraphy, 99mTc-DTPA radioaerosol scintigraphy was performed, and clearance from the lungs was measured for 10 min (1 min/frame) following termination of inhalation. 123I-MIBG lung retention index (LRI) was significantly higher in the AIPT group than the control (61 +/- 4.6 vs. 40 +/- 4.5, p = 0.01). Early LHR and LMR were significantly lower in the AIPT group than in the control group (p = 0.04, p = 0.01, respectively), whereas those of late LHR and LMR were not significantly different. T1/2 values of DTPA clearance were significantly increased in AIPT group according to the control group (55 +/- 7.2 vs. 86.6 +/- 18.5, p = 0.02). 123I-MIBG scintigraphy is a valuable tool for detecting AIPT in a rabbit model. Additionally, 99mTc-DTPA radioaerosol scintigraphy is an excellent comprehensive investigational tool for detecting AIPT with the added advantage of lower cost.</description><subject>3-Iodobenzylguanidine</subject><subject>Acetic acid</subject><subject>Aerosols</subject><subject>Amiodarone</subject><subject>Amiodarone - adverse effects</subject><subject>Amiodarone - therapeutic use</subject><subject>Animals</subject><subject>Anti-Arrhythmia Agents - adverse effects</subject><subject>Anti-Arrhythmia Agents - therapeutic use</subject><subject>Body weight</subject><subject>Comparative studies</subject><subject>Inhalation</subject><subject>Injections, Intravenous</subject><subject>Iodine</subject><subject>Iodine isotopes</subject><subject>Lung - diagnostic imaging</subject><subject>Lung - drug effects</subject><subject>Lung - pathology</subject><subject>Lung Diseases - chemically induced</subject><subject>Lung Diseases - diagnostic imaging</subject><subject>Lung Diseases - pathology</subject><subject>Lungs</subject><subject>Mediastinum</subject><subject>Medical imaging</subject><subject>Pharmaceuticals</subject><subject>Rabbits</subject><subject>Radiochemistry</subject><subject>Radioisotopes</subject><subject>Radionuclide Imaging</subject><subject>Radiopharmaceuticals</subject><subject>Reproducibility of Results</subject><subject>Respiration</subject><subject>Scintigraphy</subject><subject>Sensitivity and Specificity</subject><subject>Technetium</subject><subject>Technetium isotopes</subject><subject>Technetium Tc 99m 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of iodine-123 metaiodobenzylguanidine scintigraphy for the detection of amiodarone induced pulmonary toxicity in a rabbit model: a comparative study with technetium-99m diethyltriaminepenta acetic acid radioaerosol scintigraphy</title><author>Durmuş-Altun, Gulay ; Altun, Armagan ; Aktas, Ranan Gülhan ; Salihoglu, Yavuz Sami ; Yigitbasi, Necmi Omer</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c456t-b4ce24ddc23a25bb394e47e1c7941a2e15051a8239b772b94d5afcb6d2620dea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>3-Iodobenzylguanidine</topic><topic>Acetic acid</topic><topic>Aerosols</topic><topic>Amiodarone</topic><topic>Amiodarone - adverse effects</topic><topic>Amiodarone - therapeutic use</topic><topic>Animals</topic><topic>Anti-Arrhythmia Agents - adverse effects</topic><topic>Anti-Arrhythmia Agents - therapeutic use</topic><topic>Body weight</topic><topic>Comparative 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metaiodobenzylguanidine scintigraphy for the detection of amiodarone induced pulmonary toxicity in a rabbit model: a comparative study with technetium-99m diethyltriaminepenta acetic acid radioaerosol scintigraphy</atitle><jtitle>Annals of nuclear medicine</jtitle><addtitle>Ann Nucl Med</addtitle><date>2005-05-01</date><risdate>2005</risdate><volume>19</volume><issue>3</issue><spage>217</spage><epage>224</epage><pages>217-224</pages><issn>0914-7187</issn><eissn>1864-6433</eissn><abstract>The purpose of the study was; (i) to determine whether 123I-MIBG scintigraphy is sensitive for detection of amiodarone induced pulmonary toxicity (AIPT) and (ii) to compare it with 99mTc-DTPA radioaerosol. Twelve white New Zealand rabbit with initial mean body weight 4.24 +/- 0.47 g were divided into two groups. AIPT group (n = 7) was administered amiodarone (20 mg/kg BW). The control group (n = 5) received the same amount of 0.9% saline. All animals underwent 123I-MIBG and 99mTc-DTPA radioaerosol scintigraphy at the end of the treatment period. 123I-MIBG static thorax images were obtained during 10 minutes at 15 minutes and 3-hours after intravenous injection of the radiopharmaceutical. Lung to heart ratios (LHR) and lung to mediastinum ratios (LMR), and retention index (LRI) of 123I-MIBG were determined. Two days after 123I-MIBG scintigraphy, 99mTc-DTPA radioaerosol scintigraphy was performed, and clearance from the lungs was measured for 10 min (1 min/frame) following termination of inhalation. 123I-MIBG lung retention index (LRI) was significantly higher in the AIPT group than the control (61 +/- 4.6 vs. 40 +/- 4.5, p = 0.01). Early LHR and LMR were significantly lower in the AIPT group than in the control group (p = 0.04, p = 0.01, respectively), whereas those of late LHR and LMR were not significantly different. T1/2 values of DTPA clearance were significantly increased in AIPT group according to the control group (55 +/- 7.2 vs. 86.6 +/- 18.5, p = 0.02). 123I-MIBG scintigraphy is a valuable tool for detecting AIPT in a rabbit model. Additionally, 99mTc-DTPA radioaerosol scintigraphy is an excellent comprehensive investigational tool for detecting AIPT with the added advantage of lower cost.</abstract><cop>Japan</cop><pub>Springer Nature B.V</pub><pmid>15981675</pmid><doi>10.1007/BF02984608</doi><tpages>8</tpages></addata></record> |
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| subjects | 3-Iodobenzylguanidine Acetic acid Aerosols Amiodarone Amiodarone - adverse effects Amiodarone - therapeutic use Animals Anti-Arrhythmia Agents - adverse effects Anti-Arrhythmia Agents - therapeutic use Body weight Comparative studies Inhalation Injections, Intravenous Iodine Iodine isotopes Lung - diagnostic imaging Lung - drug effects Lung - pathology Lung Diseases - chemically induced Lung Diseases - diagnostic imaging Lung Diseases - pathology Lungs Mediastinum Medical imaging Pharmaceuticals Rabbits Radiochemistry Radioisotopes Radionuclide Imaging Radiopharmaceuticals Reproducibility of Results Respiration Scintigraphy Sensitivity and Specificity Technetium Technetium isotopes Technetium Tc 99m Pentetate Thorax Toxicity |
| title | Use of iodine-123 metaiodobenzylguanidine scintigraphy for the detection of amiodarone induced pulmonary toxicity in a rabbit model: a comparative study with technetium-99m diethyltriaminepenta acetic acid radioaerosol scintigraphy |
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