Female donors and transfusion-related acute lung injury
BACKGROUND: Although quantitative evidence is lacking, it is generally believed that the majority of cases of transfusion‐related acute lung injury (TRALI) are caused by female blood donors. We aimed to examine the relation between female donors and the occurrence of TRALI. STUDY DESIGN AND METHODS:...
Gespeichert in:
| Veröffentlicht in: | Transfusion (Philadelphia, Pa.) Pa.), 2010-11, Vol.50 (11), p.2447-2454 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2454 |
|---|---|
| container_issue | 11 |
| container_start_page | 2447 |
| container_title | Transfusion (Philadelphia, Pa.) |
| container_volume | 50 |
| creator | Middelburg, Rutger A. Van Stein, Daniëlle Zupanska, Barbara Uhrynowska, Małgorzata Gajic, Ognjen Muñiz-Diaz, Eduardo Galvez, Nuria Nogués Silliman, Christopher C. Krusius, Tom Wallis, Jonathan P. Vandenbroucke, Jan P. Briët, Ernest Van Der Bom, Johanna G. |
| description | BACKGROUND: Although quantitative evidence is lacking, it is generally believed that the majority of cases of transfusion‐related acute lung injury (TRALI) are caused by female blood donors. We aimed to examine the relation between female donors and the occurrence of TRALI.
STUDY DESIGN AND METHODS: We performed an international, multicenter case‐referent study. TRALI patients who were diagnosed clinically, independent of serology or donor sex, and had received transfusions either only from male donors or only from female donors (unisex cases) were selected. The observed sex distribution among the donors of these TRALI patients was compared to the expected sex distribution, based on the relevant donor populations.
RESULTS: Eighty‐three clinical TRALI cases were included; 67 cases received only red blood cells (RBCs), 13 only plasma‐rich products, and three both. Among RBC recipients the relative risk (RR) of TRALI after a transfusion from a female donor was 1.2 (95% confidence interval [CI], 0.69‐2.1) and among plasma‐rich product recipients the RR was 19 (95% CI, 1.9‐191). The p value for the difference between RBCs and plasma was 0.023.
CONCLUSION: Our data support the notion that plasma from female donors is associated with an increased risk of TRALI, while RBCs from female donors are not. |
| doi_str_mv | 10.1111/j.1537-2995.2010.02715.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_wiley</sourceid><recordid>TN_cdi_proquest_miscellaneous_904471445</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>904471445</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3655-49961f9a72eab1d75589cd988e86de2c861a46ec8297d13edb279a93815cf6963</originalsourceid><addsrcrecordid>eNo9kE1PwzAMhiMEEmPwH3rj1JKPJmkOHNDENlAFEhriaGWNizq6diSt2P49LUPzxZb9Pj48hESMJmyou03CpNAxN0YmnA5byjWTyf6MTE6HczKhNGUxY4JfkqsQNpRSbiibED3Hra0xcm3T-hDZxkWdt00o-1C1Teyxth26yBZ9h1HdN59R1Wx6f7gmF6WtA9789yl5nz-uZss4f108zR7yuBBKyjg1RrHSWM3RrpnTUmamcCbLMFMOeZEpZlOFRcaNdkygW3NtrBEZk0WpjBJTcnv8u_Ptd4-hg20VCqxr22DbBzA0TTVLUzkk74_Jn6rGA-x8tbX-AIzC6Ak2MOqAUQeMnuDPE-xh9TYfp4GPj3wVOtyfeOu_QGmhJXy8LGA5y58XJlcgxS8txmxy</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>904471445</pqid></control><display><type>article</type><title>Female donors and transfusion-related acute lung injury</title><source>Wiley Online Library Journals Frontfile Complete</source><creator>Middelburg, Rutger A. ; Van Stein, Daniëlle ; Zupanska, Barbara ; Uhrynowska, Małgorzata ; Gajic, Ognjen ; Muñiz-Diaz, Eduardo ; Galvez, Nuria Nogués ; Silliman, Christopher C. ; Krusius, Tom ; Wallis, Jonathan P. ; Vandenbroucke, Jan P. ; Briët, Ernest ; Van Der Bom, Johanna G.</creator><creatorcontrib>Middelburg, Rutger A. ; Van Stein, Daniëlle ; Zupanska, Barbara ; Uhrynowska, Małgorzata ; Gajic, Ognjen ; Muñiz-Diaz, Eduardo ; Galvez, Nuria Nogués ; Silliman, Christopher C. ; Krusius, Tom ; Wallis, Jonathan P. ; Vandenbroucke, Jan P. ; Briët, Ernest ; Van Der Bom, Johanna G.</creatorcontrib><description>BACKGROUND: Although quantitative evidence is lacking, it is generally believed that the majority of cases of transfusion‐related acute lung injury (TRALI) are caused by female blood donors. We aimed to examine the relation between female donors and the occurrence of TRALI.
STUDY DESIGN AND METHODS: We performed an international, multicenter case‐referent study. TRALI patients who were diagnosed clinically, independent of serology or donor sex, and had received transfusions either only from male donors or only from female donors (unisex cases) were selected. The observed sex distribution among the donors of these TRALI patients was compared to the expected sex distribution, based on the relevant donor populations.
RESULTS: Eighty‐three clinical TRALI cases were included; 67 cases received only red blood cells (RBCs), 13 only plasma‐rich products, and three both. Among RBC recipients the relative risk (RR) of TRALI after a transfusion from a female donor was 1.2 (95% confidence interval [CI], 0.69‐2.1) and among plasma‐rich product recipients the RR was 19 (95% CI, 1.9‐191). The p value for the difference between RBCs and plasma was 0.023.
CONCLUSION: Our data support the notion that plasma from female donors is associated with an increased risk of TRALI, while RBCs from female donors are not.</description><identifier>ISSN: 0041-1132</identifier><identifier>EISSN: 1537-2995</identifier><identifier>DOI: 10.1111/j.1537-2995.2010.02715.x</identifier><language>eng</language><publisher>Malden, USA: Blackwell Publishing Inc</publisher><subject>blood donors ; Females ; Injuries ; Lung</subject><ispartof>Transfusion (Philadelphia, Pa.), 2010-11, Vol.50 (11), p.2447-2454</ispartof><rights>2010 American Association of Blood Banks</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3655-49961f9a72eab1d75589cd988e86de2c861a46ec8297d13edb279a93815cf6963</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1537-2995.2010.02715.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1537-2995.2010.02715.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids></links><search><creatorcontrib>Middelburg, Rutger A.</creatorcontrib><creatorcontrib>Van Stein, Daniëlle</creatorcontrib><creatorcontrib>Zupanska, Barbara</creatorcontrib><creatorcontrib>Uhrynowska, Małgorzata</creatorcontrib><creatorcontrib>Gajic, Ognjen</creatorcontrib><creatorcontrib>Muñiz-Diaz, Eduardo</creatorcontrib><creatorcontrib>Galvez, Nuria Nogués</creatorcontrib><creatorcontrib>Silliman, Christopher C.</creatorcontrib><creatorcontrib>Krusius, Tom</creatorcontrib><creatorcontrib>Wallis, Jonathan P.</creatorcontrib><creatorcontrib>Vandenbroucke, Jan P.</creatorcontrib><creatorcontrib>Briët, Ernest</creatorcontrib><creatorcontrib>Van Der Bom, Johanna G.</creatorcontrib><title>Female donors and transfusion-related acute lung injury</title><title>Transfusion (Philadelphia, Pa.)</title><description>BACKGROUND: Although quantitative evidence is lacking, it is generally believed that the majority of cases of transfusion‐related acute lung injury (TRALI) are caused by female blood donors. We aimed to examine the relation between female donors and the occurrence of TRALI.
STUDY DESIGN AND METHODS: We performed an international, multicenter case‐referent study. TRALI patients who were diagnosed clinically, independent of serology or donor sex, and had received transfusions either only from male donors or only from female donors (unisex cases) were selected. The observed sex distribution among the donors of these TRALI patients was compared to the expected sex distribution, based on the relevant donor populations.
RESULTS: Eighty‐three clinical TRALI cases were included; 67 cases received only red blood cells (RBCs), 13 only plasma‐rich products, and three both. Among RBC recipients the relative risk (RR) of TRALI after a transfusion from a female donor was 1.2 (95% confidence interval [CI], 0.69‐2.1) and among plasma‐rich product recipients the RR was 19 (95% CI, 1.9‐191). The p value for the difference between RBCs and plasma was 0.023.
CONCLUSION: Our data support the notion that plasma from female donors is associated with an increased risk of TRALI, while RBCs from female donors are not.</description><subject>blood donors</subject><subject>Females</subject><subject>Injuries</subject><subject>Lung</subject><issn>0041-1132</issn><issn>1537-2995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNo9kE1PwzAMhiMEEmPwH3rj1JKPJmkOHNDENlAFEhriaGWNizq6diSt2P49LUPzxZb9Pj48hESMJmyou03CpNAxN0YmnA5byjWTyf6MTE6HczKhNGUxY4JfkqsQNpRSbiibED3Hra0xcm3T-hDZxkWdt00o-1C1Teyxth26yBZ9h1HdN59R1Wx6f7gmF6WtA9789yl5nz-uZss4f108zR7yuBBKyjg1RrHSWM3RrpnTUmamcCbLMFMOeZEpZlOFRcaNdkygW3NtrBEZk0WpjBJTcnv8u_Ptd4-hg20VCqxr22DbBzA0TTVLUzkk74_Jn6rGA-x8tbX-AIzC6Ak2MOqAUQeMnuDPE-xh9TYfp4GPj3wVOtyfeOu_QGmhJXy8LGA5y58XJlcgxS8txmxy</recordid><startdate>201011</startdate><enddate>201011</enddate><creator>Middelburg, Rutger A.</creator><creator>Van Stein, Daniëlle</creator><creator>Zupanska, Barbara</creator><creator>Uhrynowska, Małgorzata</creator><creator>Gajic, Ognjen</creator><creator>Muñiz-Diaz, Eduardo</creator><creator>Galvez, Nuria Nogués</creator><creator>Silliman, Christopher C.</creator><creator>Krusius, Tom</creator><creator>Wallis, Jonathan P.</creator><creator>Vandenbroucke, Jan P.</creator><creator>Briët, Ernest</creator><creator>Van Der Bom, Johanna G.</creator><general>Blackwell Publishing Inc</general><scope>BSCLL</scope><scope>7T2</scope><scope>7U2</scope><scope>C1K</scope></search><sort><creationdate>201011</creationdate><title>Female donors and transfusion-related acute lung injury</title><author>Middelburg, Rutger A. ; Van Stein, Daniëlle ; Zupanska, Barbara ; Uhrynowska, Małgorzata ; Gajic, Ognjen ; Muñiz-Diaz, Eduardo ; Galvez, Nuria Nogués ; Silliman, Christopher C. ; Krusius, Tom ; Wallis, Jonathan P. ; Vandenbroucke, Jan P. ; Briët, Ernest ; Van Der Bom, Johanna G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3655-49961f9a72eab1d75589cd988e86de2c861a46ec8297d13edb279a93815cf6963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>blood donors</topic><topic>Females</topic><topic>Injuries</topic><topic>Lung</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Middelburg, Rutger A.</creatorcontrib><creatorcontrib>Van Stein, Daniëlle</creatorcontrib><creatorcontrib>Zupanska, Barbara</creatorcontrib><creatorcontrib>Uhrynowska, Małgorzata</creatorcontrib><creatorcontrib>Gajic, Ognjen</creatorcontrib><creatorcontrib>Muñiz-Diaz, Eduardo</creatorcontrib><creatorcontrib>Galvez, Nuria Nogués</creatorcontrib><creatorcontrib>Silliman, Christopher C.</creatorcontrib><creatorcontrib>Krusius, Tom</creatorcontrib><creatorcontrib>Wallis, Jonathan P.</creatorcontrib><creatorcontrib>Vandenbroucke, Jan P.</creatorcontrib><creatorcontrib>Briët, Ernest</creatorcontrib><creatorcontrib>Van Der Bom, Johanna G.</creatorcontrib><collection>Istex</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Safety Science and Risk</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Transfusion (Philadelphia, Pa.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Middelburg, Rutger A.</au><au>Van Stein, Daniëlle</au><au>Zupanska, Barbara</au><au>Uhrynowska, Małgorzata</au><au>Gajic, Ognjen</au><au>Muñiz-Diaz, Eduardo</au><au>Galvez, Nuria Nogués</au><au>Silliman, Christopher C.</au><au>Krusius, Tom</au><au>Wallis, Jonathan P.</au><au>Vandenbroucke, Jan P.</au><au>Briët, Ernest</au><au>Van Der Bom, Johanna G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Female donors and transfusion-related acute lung injury</atitle><jtitle>Transfusion (Philadelphia, Pa.)</jtitle><date>2010-11</date><risdate>2010</risdate><volume>50</volume><issue>11</issue><spage>2447</spage><epage>2454</epage><pages>2447-2454</pages><issn>0041-1132</issn><eissn>1537-2995</eissn><abstract>BACKGROUND: Although quantitative evidence is lacking, it is generally believed that the majority of cases of transfusion‐related acute lung injury (TRALI) are caused by female blood donors. We aimed to examine the relation between female donors and the occurrence of TRALI.
STUDY DESIGN AND METHODS: We performed an international, multicenter case‐referent study. TRALI patients who were diagnosed clinically, independent of serology or donor sex, and had received transfusions either only from male donors or only from female donors (unisex cases) were selected. The observed sex distribution among the donors of these TRALI patients was compared to the expected sex distribution, based on the relevant donor populations.
RESULTS: Eighty‐three clinical TRALI cases were included; 67 cases received only red blood cells (RBCs), 13 only plasma‐rich products, and three both. Among RBC recipients the relative risk (RR) of TRALI after a transfusion from a female donor was 1.2 (95% confidence interval [CI], 0.69‐2.1) and among plasma‐rich product recipients the RR was 19 (95% CI, 1.9‐191). The p value for the difference between RBCs and plasma was 0.023.
CONCLUSION: Our data support the notion that plasma from female donors is associated with an increased risk of TRALI, while RBCs from female donors are not.</abstract><cop>Malden, USA</cop><pub>Blackwell Publishing Inc</pub><doi>10.1111/j.1537-2995.2010.02715.x</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0041-1132 |
| ispartof | Transfusion (Philadelphia, Pa.), 2010-11, Vol.50 (11), p.2447-2454 |
| issn | 0041-1132 1537-2995 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_904471445 |
| source | Wiley Online Library Journals Frontfile Complete |
| subjects | blood donors Females Injuries Lung |
| title | Female donors and transfusion-related acute lung injury |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T21%3A42%3A58IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_wiley&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Female%20donors%20and%20transfusion-related%20acute%20lung%20injury&rft.jtitle=Transfusion%20(Philadelphia,%20Pa.)&rft.au=Middelburg,%20Rutger%20A.&rft.date=2010-11&rft.volume=50&rft.issue=11&rft.spage=2447&rft.epage=2454&rft.pages=2447-2454&rft.issn=0041-1132&rft.eissn=1537-2995&rft_id=info:doi/10.1111/j.1537-2995.2010.02715.x&rft_dat=%3Cproquest_wiley%3E904471445%3C/proquest_wiley%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=904471445&rft_id=info:pmid/&rfr_iscdi=true |