Simplified quantification of myocardial flow reserve with flurpiridaz F 18: validation with microspheres in a pig model

The novel PET flow tracer flurpiridaz F 18 shows high myocardial extraction and slow washout. flurpiridaz F 18 PET data analysis with tracer kinetic modeling provides accurate absolute myocardial blood flow (MBF) measurements but requires in-scanner injection and complex processing. We evaluated the...

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Veröffentlicht in:	Journal of Nuclear Medicine 2011-04, Vol.52 (4), p.617-624
Hauptverfasser:	Sherif, Hossam M, Nekolla, Stephan G, Saraste, Antti, Reder, Sybille, Yu, Ming, Robinson, Simon, Schwaiger, Markus
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Animals Cardiotonic Agents Cardiovascular disease Coronary Circulation - physiology Dobutamine Gated Blood-Pool Imaging Heart - diagnostic imaging Hogs Image Processing, Computer-Assisted Medical imaging Microspheres Myocardium - metabolism Positron-Emission Tomography Pyridazines - pharmacokinetics Radiopharmaceuticals - pharmacokinetics Regression Analysis Reproducibility of Results Scintillation Counting Studies Swine
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