A unique hybrid renal mononuclear phagocyte activation phenotype in murine systemic lupus erythematosus nephritis

Renal infiltration with mononuclear cells is associated with poor prognosis in systemic lupus erythematosus. A renal macrophage/dendritic cell signature is associated with the onset of nephritis in NZB/W mice, and immune-modulating therapies can reverse this signature and the associated renal damage...

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Veröffentlicht in:	The Journal of immunology (1950) 2011-04, Vol.186 (8), p.4994-5003
Hauptverfasser:	Bethunaickan, Ramalingam, Berthier, Celine C, Ramanujam, Meera, Sahu, Ranjit, Zhang, Weijia, Sun, Yezou, Bottinger, Erwin P, Ivashkiv, Lionel, Kretzler, Matthias, Davidson, Anne
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Differentiation - genetics Antigens, Differentiation - immunology Antigens, Differentiation - metabolism Blotting, Western Cyclophosphamide - pharmacology Female Flow Cytometry Gene Expression Profiling Immunophenotyping Immunosuppressive Agents - pharmacology Interleukin-10 - genetics Interleukin-10 - immunology Interleukin-10 - metabolism Kidney - immunology Kidney - metabolism Leukocytes, Mononuclear - immunology Leukocytes, Mononuclear - metabolism Leukocytes, Mononuclear - ultrastructure Lupus Nephritis - drug therapy Lupus Nephritis - genetics Lupus Nephritis - immunology Macrophages - immunology Macrophages - metabolism Macrophages - ultrastructure Male Mice Mice, 129 Strain Mice, Inbred NZB Mice, Inbred Strains Microscopy, Electron, Scanning Oligonucleotide Array Sequence Analysis Phagocytes - immunology Phagocytes - metabolism Phagocytes - ultrastructure Remission Induction Reverse Transcriptase Polymerase Chain Reaction Time Factors
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