Structure and function of active chromatin and DNase I hypersensitive sites
Chromatin is by its very nature a repressive environment which restricts the recruitment of transcription factors and acts as a barrier to polymerases. Therefore the complex process of gene activation must operate at two levels. In the first instance, localized chromatin decondensation and nucleosom...
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| Veröffentlicht in: | The FEBS journal 2011-07, Vol.278 (13), p.2182-2210 |
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| creator | Cockerill, Peter N |
| description | Chromatin is by its very nature a repressive environment which restricts the recruitment of transcription factors and acts as a barrier to polymerases. Therefore the complex process of gene activation must operate at two levels. In the first instance, localized chromatin decondensation and nucleosome displacement is required to make DNA accessible. Second, sequence-specific transcription factors need to recruit chromatin modifiers and remodellers to create a chromatin environment that permits the passage of polymerases. In this review I will discuss the chromatin structural changes that occur at active gene loci and at regulatory elements that exist as DNase I hypersensitive sites. |
| doi_str_mv | 10.1111/j.1742-4658.2011.08128.x |
| format | Article |
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| subjects | Animals Chromatin Chromatin - physiology Chromatin - ultrastructure deoxyribonuclease I Deoxyribonuclease I - chemistry Deoxyribonuclease I - metabolism DNA DNase I hypersensitive Enzymes gene activation Gene expression gene regulation genes Humans loci Molecular biology nucleosome nucleosomes transcription transcription factors Transcriptional Activation |
| title | Structure and function of active chromatin and DNase I hypersensitive sites |
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