Prenatal and concurrent exposure to halogenated organic compounds and gene expression of CYP17A1, CYP19A1, and oestrogen receptor α and β genes

Objective To determine whether prenatal exposure to dichlorodiphenyl ethylene (DDE) and polychlorinated biphenyls (PCBs) and concurrent exposure to DDE, PCBs and polybrominated diphenylethers (PBDEs) affect gene expression of aromatase (CYP19A1), 17-α-hydroxylase (CYP17A1), and oestrogen receptors α...

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Veröffentlicht in:	Occupational and environmental medicine (London, England) England), 2011-06, Vol.68 (6), p.430-437
Hauptverfasser:	Karmaus, Wilfried, Osuch, Janet Rose, Landgraf, Jeff, Taffe, Bonita, Mikucki, Dorota, Haan, Pam
Format:	Artikel
Sprache:	eng
Schlagworte:	17-α-hydroxylase Adult Adults Animals aromatase Aromatase - biosynthesis Aromatase - genetics Biological and medical sciences Carrier Proteins - biosynthesis Carrier Proteins - genetics Chemical and industrial products toxicology. Toxic occupational diseases Chemical hazards Cohort Studies Congeners dde Dichlorodiphenyl Dichloroethylene - blood Dichlorodiphenyl Dichloroethylene - pharmacology endocrine disorders Environment Environmental Exposure - analysis epidemiology Estrogen Receptor alpha - biosynthesis Estrogen Receptor alpha - genetics Estrogens Female female reproductive effects and adverse pregnancy outcomes Fishes Food Contamination Gene expression Gene Expression Regulation - drug effects Genes Halogenated diphenyl ethers Humans Hydrocarbons, Halogenated - pharmacology Lipids Medical sciences Middle Aged Nuclear Proteins - biosynthesis Nuclear Proteins - genetics oestrogen receptor PBDE PCB pesticides Polychlorinated biphenyls Polychlorinated Biphenyls - blood Polychlorinated Biphenyls - pharmacology Pregnancy prenatal exposure Prenatal Exposure Delayed Effects Receptors Steroid 17-alpha-Hydroxylase - biosynthesis Steroid 17-alpha-Hydroxylase - genetics Toxicology Various organic compounds women Young Adult
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