UVA1 Genotoxicity Is Mediated Not by Oxidative Damage but by Cyclobutane Pyrimidine Dimers in Normal Mouse Skin

UVA1 induces the formation of 8-hydroxy-2′-deoxyguanosines (8-OH-dGs) and cyclobutane pyrimidine dimers (CPDs) in the cellular genome. However, the relative contribution of each type of damage to the in vivo genotoxicity of UVA1 has not been clarified. We irradiated living mouse skin with 364-nm UVA...

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Veröffentlicht in:	Journal of investigative dermatology 2008-09, Vol.128 (9), p.2289-2296
Hauptverfasser:	Ikehata, Hironobu, Kawai, Kazuaki, Komura, Jun-ichiro, Sakatsume, Ko, Wang, Liangcheng, Imai, Masaru, Higashi, Shoichi, Nikaido, Osamu, Yamamoto, Kazuo, Hieda, Kotaro, Watanabe, Masakatsu, Kasai, Hiroshi, Ono, Tetsuya
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cytosine - metabolism Deoxyguanosine - analogs & derivatives Deoxyguanosine - metabolism DNA - genetics DNA - metabolism DNA - radiation effects DNA Damage - genetics DNA Damage - radiation effects Dose-Response Relationship, Radiation Epidermis - cytology Epidermis - metabolism Epidermis - radiation effects Mice Mice, Transgenic Mutation - genetics Mutation - radiation effects Oxidative Stress - radiation effects Pyrimidine Dimers - metabolism Reactive Oxygen Species - metabolism Skin - cytology Skin - metabolism Skin - radiation effects Thymine - metabolism Ultraviolet Rays - adverse effects
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