Polypyrimidine Tract-Binding Protein 2 Binds to Selective, Intronic Messenger RNA and MicroRNA Targets in the Mouse Testis

Here we use an in vivo cross-linking and immunoprecipitation procedure to detect RNA targets of the multifunctional RNA-binding protein polypyrimidine tract-binding protein (PTBP) 2 in mouse testis. Eleven known mRNAs, including Ptbp2 mRNA, 28 RNAs matching intron sequences, and 12 small RNAs and re...

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Veröffentlicht in:	Biology of reproduction 2011-03, Vol.84 (3), p.435-439
Hauptverfasser:	Xu, Mingang, Hecht, Norman B
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing - physiology Animals Base Sequence Biological and medical sciences Cell Line Cross-Linking Reagents - pharmacology developmental biology Fundamental and applied biological sciences. Psychology gametogenesis Gene Expression Regulation gene regulation Immunoprecipitation - methods Inteins Male Mice MicroRNAs - metabolism miRNAs Molecular Sequence Data mRNAs Nerve Tissue Proteins - metabolism Polypyrimidine Tract-Binding Protein - metabolism Protein Binding RNA, Messenger - metabolism RNA-binding proteins spermatogenesis splicing Substrate Specificity testis Testis - metabolism Vertebrates: reproduction
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