RNAi knockdown of Hop (Hsp70/Hsp90 organising protein) decreases invasion via MMP-2 down regulation

Abstract We previously identified Hop as over expressed in invasive pancreatic cancer cell lines and malignant tissues of pancreatic cancer patients, suggesting an important role for Hop in the biology of invasive pancreatic cancer. Hop is a co-chaperone protein that binds to both Hsp70/Hsp90. We hy...

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Veröffentlicht in:	Cancer letters 2011-07, Vol.306 (2), p.180-189
Hauptverfasser:	Walsh, Naomi, Larkin, AnneMarie, Swan, Niall, Conlon, Kevin, Dowling, Paul, McDermott, Ray, Clynes, Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma, Mucinous - metabolism Adenocarcinoma, Mucinous - prevention & control Adenocarcinoma, Mucinous - secondary Blotting, Western Cancer therapies Carcinoma, Pancreatic Ductal - metabolism Carcinoma, Pancreatic Ductal - prevention & control Carcinoma, Pancreatic Ductal - secondary Cell Adhesion Cell division Cell Movement Cloning Down-Regulation Gene Expression Regulation, Neoplastic genes Heat shock proteins Heat-Shock Proteins - antagonists & inhibitors Heat-Shock Proteins - genetics Heat-Shock Proteins - metabolism Hematology, Oncology and Palliative Medicine Hop/STIP1/STI1 (Hsp70/Hsp90-organising protein) HSP70 Heat-Shock Proteins - metabolism HSP90 Heat-Shock Proteins - metabolism Humans Immunoenzyme Techniques Immunohistochemistry Immunoprecipitation In vitro invasion Kinases Matrix Metalloproteinase 2 - metabolism Matrix Metalloproteinase Inhibitors Membranes MMP-2 Molecular Chaperones Neoplasm Invasiveness Pancreas Pancreatic cancer pancreatic neoplasms Pancreatic Neoplasms - metabolism Pancreatic Neoplasms - pathology Pancreatic Neoplasms - prevention & control patients Phosphorylation proteins RNA RNA, Small Interfering - genetics signal transduction therapeutics Tumor Cells, Cultured Tumors
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